{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,11]],"date-time":"2024-09-11T10:35:53Z","timestamp":1726050953520},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Multidrug resistance Plasmodium falciparum is the major health problem in Thailand. Discovery and development of new antimalarial drugs with novel modes of action is urgently required. The aim of the present study was to investigate the antimalarial interaction of 9-hydroxycalabaxanthone and \u03b1-mangostin with the standard antimalarial drugs mefloquine and artesunate in chloroquine sensitive (3D7) and chloroquine resistant (K1) P. falciparum clones in vitro. Median (range) IC50 (drug concentration which produces 50% parasite growth inhibition) values of the 9-hydroxycalabaxanthone, \u03b1-mangostin, artesunate and mefloquine for 3D7 vs K1 clones were 1.5 (0.9-2.1) vs 1.2 (1.1-1.6) \u03bcM, 17.9 (15.7.0-20.0) vs 9.7 (6.0-14.0) \u03bcM, 1.0 (0.4-3.0) vs 1.7 (1.0-2.5) nM, and 13.3 (11.1-13.3) vs 7.1 (6.7-12.2) nM, respectively. Analysis of isobologram and combination index (CI) of 9-hydroxycalabaxanthone with artesunate or mefloquine showed synergistic and indifference antimalarial interaction, respectively. \u03b1-mangostin-artesunate combination exhibited a slight antagonistic effect of antimalarial interaction, whereas \u03b1-mangostin and mefloquine combination showed indifference interaction in both clones. The combination of 9-hydroxycalabaxanthone with \u03b1-mangostin showed the synergistic antimalarial interaction in both clones<\/jats:p>","DOI":"10.1515\/ap-2015-0013","type":"journal-article","created":{"date-parts":[[2015,4,20]],"date-time":"2015-04-20T09:27:21Z","timestamp":1429522041000},"source":"Crossref","is-referenced-by-count":8,"title":["The in vitro antimalarial interaction of 9-hydroxycalabaxanthone and \u03b1-mangostin with mefloquine\/artesunate"],"prefix":"10.1007","volume":"60","author":[{"given":"Wanna","family":"Chaijaroenkul","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kesara","family":"Na-Bangchang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref151","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1038\/ja.2008.70","article-title":"Antimalarial compounds from the root bark of Garcinia polyantha Olv of ST JSTAGE \/ antibiotics pii","author":"Lannang","year":"2008","journal-title":"The Journal Antibiotics"},{"key":"ref201","first-page":"90","article-title":"Antiproliferation , antioxidation and induction of apoptosis by Garcinia mangostana ( mangosteen ) on SKBR human breast cancer cell line pii","author":"Moongkarndi","year":"2004","journal-title":"Journal of Ethnopharmacology"},{"key":"ref191","first-page":"32","article-title":"Artemisinin : mechanisms of action , resistance and toxicity for pii","author":"Meshnick","year":"2002","journal-title":"International Journal Parasitology"},{"key":"ref11","first-page":"48","article-title":"Novel rapid and inexpensive cell - 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