{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T08:46:39Z","timestamp":1789634799745,"version":"4.0.0"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fascioliasis has recently been included in the WHO list of Neglected Zoonotic Diseases. Besides being a major veterinary health problem, fascioliasis has large underdeveloping effects on the human communities affected. Though scarcely considered in fascioliasis epidemiology, it is well recognized that both native and introduced wildlife species may play a significant role as reservoirs of the disease. The objectives are to study the morphological characteristics of Fasciola hepatica adults and eggs in a population of Lepus europaeus, to assess liver fluke prevalence, and to analyze the potential reservoir role of the European brown hare in northern Patagonia, Argentina, where fascioliasis is endemic. Measures of F. hepatica found in L. europaeus from northern Patagonia demonstrate that the liver fluke is able to fully develop in wild hares and to shed normal eggs through their faeces. Egg shedding to the environment is close to the lower limit obtained for pigs, a domestic animal whose epidemiological importance in endemic areas has already been highlighted. The former, combined with the high prevalence found (14.28%), suggest an even more important role in the transmission cycle than previously considered. The results obtained do not only remark the extraordinary plasticity and adaptability of this trematode species to different host species, but also highlight the role of the European brown hare, and other NIS, as reservoirs capable for parasite spillback to domestic and native cycle, representing a potentially important, but hitherto neglected, cause of disease emergence.<\/jats:p>","DOI":"10.1515\/ap-2015-0076","type":"journal-article","created":{"date-parts":[[2015,6,16]],"date-time":"2015-06-16T17:39:53Z","timestamp":1434476393000},"source":"Crossref","is-referenced-by-count":15,"title":["Liver fluke (Fasciola hepatica) naturally infecting introduced European brown hare (Lepus europaeus) in northern Patagonia: phenotype, prevalence and potential risk"],"prefix":"10.1007","volume":"60","author":[{"given":"Pablo F.","family":"Cuervo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia Di","family":"Cataldo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Cecilia","family":"Fantozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Deis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela Diaz","family":"Isenrath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Viberti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricio","family":"Artigas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Peixoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Adela","family":"Valero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto Mera y","family":"Sierra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Mas-Coma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"ref441","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/S0304-4017(01)00499-X","article-title":"Mas a Relationships between host species and morphometric patterns in Fasciola hepatica adults and eggs from the northern Bolivian Altiplano hyperendemic region","volume":"102","author":"Valero","year":"2001","journal-title":"Veterinary Parasitology"},{"key":"ref11","first-page":"317","article-title":"Mas - Coma Impact of climate change and man - made irrigation systems on the transmission risk long - term trend and seasonality of human and animal fascioliasis in Pakistan","volume":"8","author":"Afshan","year":"2014","journal-title":"Geospatial Health"},{"key":"ref511","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.actatropica.2009.04.005","article-title":"Mas Fluke eggs characteristics for the diagnosis of human and animal fascioliasis by Fasciola hepatica and Fasciola gigantica","author":"Valero","year":"2009","journal-title":"Acta Tropica"},{"key":"ref271","doi-asserted-by":"publisher","first-page":"1758","DOI":"10.1016\/j.vetpar.2013.09.009","article-title":"Mas The wild boar ( Sus scrofa Linnaeus as secondary reservoir of Fasciola hepatica in Galicia","author":"Mezo","year":"2013","journal-title":"Veterinary Parasitology"},{"key":"ref91","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/S0001-706X(01)00106-1","article-title":"Mas Validation of a mapping and predicting model for human fasciolosis transmission in Andean very high altitude endemic areas using remote sensing data","volume":"79","author":"Fuentes","year":"2001","journal-title":"Acta Tropica"},{"key":"ref261","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1186\/1756-3305-4-104","article-title":"Mas Human fascioliasis in Argentina : retrospective overview critical analysis and baseline for future research and","volume":"4","author":"Mera","year":"2011","journal-title":"Parasites Vectors"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1128\/AAC.15.3.372","article-title":"Avermectins new family of potent anthelmintic agents : efficacy of the B a component and","volume":"15","author":"Egerton","year":"1979","journal-title":"Antimicrobial Agents Chemotherapy"},{"key":"ref461","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1645\/0022-3395(2002)088[0308:PISASO]2.0.CO;2","article-title":"Mas Patterns in size and shedding of Fasciola hepatica eggs by naturally and experimentally infected murid rodents","volume":"88","author":"Valero","year":"2002","journal-title":"Journal of Parasitology"},{"key":"ref421","doi-asserted-by":"crossref","first-page":"17","DOI":"10.14411\/fp.2000.004","article-title":"Mas Comparative infectivity of Fasciola hepatica metacercariae from isolates of the main and secondary reservoir animal host species in the Bolivian Altiplano high human endemic region","volume":"47","author":"Valero","year":"2000","journal-title":"Folia Parasitologica"},{"key":"ref471","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1086\/377281","article-title":"Mas Risk of gallstone disease in advanced chronic phase of fascioliasis : an experimental study in a rat model","author":"Valero","year":"2003","journal-title":"Journal of Infectious Diseases"},{"key":"ref521","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.vetpar.2011.07.003","article-title":"Mas Correlation between egg - 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