{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T17:43:33Z","timestamp":1773423813448,"version":"3.50.1"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Schistosomiasis is a debilitating parasitic disease, affects large number of host species. Currently affects 250-300 million people in tropic areas. Schistosoma pathogenic impact is hepatic periportal fibrosis; the parasite-induced inflammatory cellular activation promotes oxidative stress, resulting in lipid peroxidation (LPO), with subsequent increase in inflammatory mediators as malondialdehyde (MDA). This study was set up to reveal possible contribution of lipid peroxidation byproducts MDA in hepatic pathophysiology. Results displayed that MDA don\u2019t tend to change in relation with either age, nor hepatic transaminases AST &amp; ALT, while exhibited a significant increase in MDA levels in human schistosomiasis versus control group P&lt;0.0001 (Mn. \u00b1 St.dev. 7.77 \u00b1 3.59, 1.21 \u00b1 0.28 nmol\/ml) respectively. Moreover; MDA plasma levels in Schistosoma infected group correlated significantly with two hepatic fibrosis parameters; (a) ultrasonography graded periportal fibrosis P&lt; 0.0001. Levels of MDA in hepatic fibrosis grades 0, I, II, III in Schistosoma infected group were (Mn. \u00b1 St.dev. 2.8 \u00b1 0.64, 4.3 \u00b1 1.2, 9.3 \u00b1 1.6 and 10.8 \u00b1 1.3 nmol\/ml) respectively, (b) serum Hyaluronic acid (HA) P&lt;0.0001 (spearman r = 0.77) as a reliable hepatic fibrosis marker. This implies a considerable role of LPO byproducts in schistosomiasis pathogenicity, and proposing malondialdehyde as a biomarker for schistosomiasis morbidity.<\/jats:p>","DOI":"10.1515\/ap-2015-0105","type":"journal-article","created":{"date-parts":[[2015,9,25]],"date-time":"2015-09-25T08:59:12Z","timestamp":1443171552000},"source":"Crossref","is-referenced-by-count":13,"title":["Malondialdehyde; Lipid peroxidation plasma biomarker correlated with hepatic fibrosis in human Schistosoma mansoni infection"],"prefix":"10.1007","volume":"60","author":[{"given":"Inas Abdel","family":"Aziz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariam","family":"Yacoub","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laila","family":"Rashid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad","family":"Solieman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref61","first-page":"1","article-title":"Infection and disease in human schistosomiasis mansoni are under distinct major gene control","author":"Dessein","year":"1999","journal-title":"Microbes and Infection"},{"key":"ref181","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/S0140-6736(05)66457-4","article-title":"Reassessment of the cost of chronic helmintic infection : a meta - analysis of disabilityrelated outcomes in endemic schistosomiasis","author":"King","year":"2005","journal-title":"Lancet"},{"key":"ref301","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1098\/rstb.1985.0168","article-title":"Oxidative Stress : Damage to Intact Cells and Organs [ and Discussion ] Philosophical Transactions of the","author":"Sies","year":"1985","journal-title":"Royal Society B : Biological Sciences"},{"key":"ref151","first-page":"15","article-title":"The measurement and mechanism of lipid peroxidation in biological systems","author":"Gutteridge","year":"1990","journal-title":"Trends in Biochemical Sciences"},{"key":"ref171","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1371\/journal.pmed.0030102","article-title":"Incorporating a rapid - impact package for neglected tropical diseases with programs for HIV tuberculosis and malaria","author":"Hotez","year":"2006","journal-title":"AIDS PLoS Med"},{"key":"ref241","first-page":"1214","article-title":"Plasma malondialdehyde as biomarker for oxidative stress : reference interval and effects of life - style factors","author":"Nielsen","year":"1997","journal-title":"Clinical Chemistry"},{"key":"ref01","first-page":"19","article-title":"Visualization of oxygen radical production in mouse liver in response to infection with Schistosoma mansoni","author":"Abdallahi","year":"1999","journal-title":"Liver"},{"key":"ref291","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1590\/S0100-879X2005000500012","article-title":"Serum laminin , type IV collagen and hyaluronan as fibrosis markers in non - alcoholic fatty liver disease","author":"Santos","year":"2005","journal-title":"Brazilian Journal Of Medical and Biological Research"},{"key":"ref71","first-page":"106","article-title":"Ultrasound versus biological markers in the evaluation of periportal fibrosis in human Schistosoma mansoni Mem\u00f3rias do Instituto Oswaldo","author":"Domingues","year":"2011","journal-title":"Cruz"},{"key":"ref221","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1093\/carcin\/21.3.361","article-title":"Oxyradicals and DNA damage","author":"Marnett","year":"2000","journal-title":"Carcinogenesis"},{"key":"ref261","first-page":"59","article-title":"Serum hyaluronan as a marker of liver fibrosis in asymptomatic chronic viral hepatitis B of Clinical and Laboratory Investigation","author":"Pontinha","year":"1999","journal-title":"Scandinavian Journal"},{"key":"ref121","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1080\/10715760600592962","article-title":"Age - associated analysis of oxidative stress parameters in human plasma and erythrocytes Free Radic","author":"Gil","year":"2006","journal-title":"Res"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1086\/430929","article-title":"Nutritional status and serum cytokine profiles in children adolescents , and young adults with Schistosoma japonicum - associated hepatic fibrosis in Leyte Philippines","author":"Coutinho","year":"2005","journal-title":"The Journal of Infectious Diseases"},{"key":"ref201","first-page":"56","article-title":"Evaluation of lipid peroxidation by measuring thiobarbituric acid reactive substances","author":"Lef\u00e8vre","year":"1998","journal-title":"Annales De Biologie Clinique"},{"key":"ref321","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1111\/j.1365-2613.2008.00608.x","article-title":"An intravital microscopic study of the hepatic microcirculation in cirrhotic mice models : relationship between fibrosis and angiogenesis","author":"Vanheule","year":"2008","journal-title":"International Journal of Experimental Pathology"},{"key":"ref161","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/1476-5926-4-6","article-title":"Accuracy of hyaluronic acid level for predicting liver fibrosis stages in patients with hepatitis C virus","author":"Halfon","year":"2005","journal-title":"Comparative Hepatology"},{"key":"ref141","first-page":"15","article-title":"Noninvasive Biochemical Markers of Liver Fibrosis","author":"Grigorescu","year":"2006","journal-title":"Journal of Gastrointestinal and Liver Diseases"},{"key":"ref191","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/S0001-706X(02)00136-5","article-title":"Serum hyaluronic acid as a comprehensive marker to assess severity of liver disease in schistosomiasis","author":"K\u00f6pke","year":"2002","journal-title":"Acta Tropica"},{"key":"ref281","first-page":"77","article-title":"Evolution of schistosomiasis - induced pathology after therapy and interruption of exposure to schistosomes : a review of ultrasonographic studies","author":"Richter","year":"2000","journal-title":"Acta Tropica"},{"key":"ref331","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.actatropica.2005.07.005","article-title":"The public health significance and control of schistosomiasis in China - then and now","author":"Zhou","year":"2005","journal-title":"Acta Tropica"},{"key":"ref271","first-page":"96","article-title":"Report of the Second Satellite Symposium on Ultrasound in Schistosomiasis Mem\u00f3rias do Instituto Oswaldo","author":"Richter","year":"2001","journal-title":"Cruz"},{"key":"ref91","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/j.1365-3024.2008.01061.xEsterbauerH.,SchaurR.J.,ZollnerH.1991.4-hydroxynonenal,malonaldehyderelatedaldehydes.11,81-128","article-title":"and reactive oxygen species are elevated in Egyptian patients affected with schistosomal liver disease Chemistry and biochemistry of","author":"Elsammak","year":"2008","journal-title":"IL Parasite Immunology Free Radical Biology and Medicine"},{"key":"ref251","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1038\/nri843","article-title":"The immunobiology of schistosomiasis","author":"Pearce","year":"2002","journal-title":"Nature Reviews Immunology"},{"key":"ref231","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1620\/tjem.213.261","article-title":"Aging - related oxidative stress in healthy humans","author":"Mendoza","year":"2007","journal-title":"Tohoku Journal of Experimental Medicine"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.actatropica.2005.03.001","article-title":"Circulating markers of oxidative stress and liver fibrosis in Sudanese subjects at risk of schistosomiasis and hepatitis","author":"Eboumbou","year":"2005","journal-title":"Acta Tropica"},{"key":"ref111","first-page":"37","article-title":"Elevated levels of erythrocyte - conjugated dienes indicate increased lipid peroxidation in schistosomiasis mansoni patients","author":"Facundo","year":"2004","journal-title":"Brazilian Journal Of Medical and Biological Research"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"57","DOI":"10.2478\/s11686-012-0026-5","article-title":"Levels of oxidative stress markers : correlation with hepatic function and worm burden patients with schistosomiasis","author":"Cunha","year":"2012","journal-title":"Acta Parasitologica"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1590\/0074-0276140266","article-title":"Low transformation growth factor - \u03b2 production and collagen synthesis correlate with the lack of hepatic periportal fibrosis development in undernourished mice infected with Schistosoma mansoni Mem\u00f3rias do Instituto Oswaldo","author":"Barros","year":"2014","journal-title":"Cruz"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.actatropica.2006.03.006","article-title":"Repeated infections with Schistosoma mansoni and liver fibrosis in undernourished mice","author":"Coutinho","year":"2007","journal-title":"Acta Tropica"},{"key":"ref101","first-page":"57","article-title":"Cytotoxicity and genotoxicity of lipid - oxidation products","author":"Esterbauer","year":"1993","journal-title":"The American Journal of Clinical Nutrition"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1007\/s12038-013-9329-4","article-title":"Biomphalaria alexandrina in Egypt : Past , present and future","author":"Abou","year":"2013","journal-title":"Journal of Biosciences"},{"key":"ref211","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.actatropica.2007.01.004","article-title":"Evaluation of splenomegaly in the hepatosplenic form of mansonic schistosomiasis","author":"Maia","year":"2007","journal-title":"Acta Tropica"},{"key":"ref311","first-page":"13","article-title":"Malonyldialdehyde content of cell membranes is the most important marker of oxidative stress in haemodialysis patients","author":"Taccone","year":"1998","journal-title":"Nephrology Dialysis Transplantation"}],"container-title":["Acta Parasitologica"],"original-title":[],"link":[{"URL":"https:\/\/www.degruyter.com\/view\/j\/ap.2015.60.issue-4\/ap-2015-0105\/ap-2015-0105.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T16:40:21Z","timestamp":1607964021000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/view\/j\/ap.2015.60.issue-4\/ap-2015-0105\/ap-2015-0105.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,1]]},"references-count":33,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.1515\/ap-2015-0105","relation":{},"ISSN":["1896-1851","1230-2821"],"issn-type":[{"value":"1896-1851","type":"electronic"},{"value":"1230-2821","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1,1]]}}}