{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:29:18Z","timestamp":1762522158237,"version":"3.41.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,6,26]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Despite the fact vector-borne diseases (VBDs) have been increasingly reported in dogs worldwide, there are only limited reports on VBDs in dogs in China with most being based on molecular detection of active infections. To provide further data on the exposure of dogs in China to VBD agents, we used commercial immunochromatographic assays to test plasma from 637 apparently healthy indoor and breeding colony dogs from 21 veterinary clinics in 10 provinces in China and a commercial dog breeding facility for circulating antigen of<jats:italic>Dirofilaria immitis<\/jats:italic>, and for circulating antibodies against<jats:italic>Ehrlichia<\/jats:italic>spp.,<jats:italic>Anaplasma<\/jats:italic>spp., and<jats:italic>Borrelia burgdorferi<\/jats:italic>. Overall, we found only low levels of exposure to<jats:italic>Ehrlichia<\/jats:italic>spp. (4.7%; 30\/637),<jats:italic>Anaplasma<\/jats:italic>spp. (1.4%; 9\/637),<jats:italic>B<\/jats:italic>.<jats:italic>burgdorferi<\/jats:italic>(0.9%; 6\/637) and<jats:italic>D<\/jats:italic>.<jats:italic>immitis<\/jats:italic>(0.2%; 1\/637) with most of the positive animals coming from the commercial breeding colony (26\/103; 25.2%) where ectoparasites were most commonly noted. At least one vector-borne agent was found in dogs from 6 of the 10 provinces investigated. Our results confirm exposure of dogs from around China to a variety of VBDs, even indoor pets seldom observed to harbor ectoparasites.<\/jats:p>","DOI":"10.1515\/ap-2018-0047","type":"journal-article","created":{"date-parts":[[2018,4,14]],"date-time":"2018-04-14T22:16:02Z","timestamp":1523744162000},"page":"412-415","source":"Crossref","is-referenced-by-count":11,"title":["Detection of Dirofilaria immitis antigen and antibodies against Anaplasma phagocytophilum, Borrelia burgdorferi and Ehrlichia canis in dogs from ten provinces of China"],"prefix":"10.1007","volume":"63","author":[{"given":"Jiawei","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jilei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengsheng","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunlian","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofeng","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongqing","family":"Hao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiju","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heba S.","family":"El-Mahallawy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenbin","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianji","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinjun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"ref261","doi-asserted-by":"crossref","first-page":"375","DOI":"10.3347\/kjp.2013.51.3.375","article-title":"Prevalence of Dirofilaria immitis in dogs in Shenyang, Northeastern China","volume":"51","year":"2013","journal-title":"Korean Journal of Parasitology"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1128\/CMR.00012-12","article-title":"Human and animal dirofilariasis: the emergence of a zoonotic mosaic","volume":"25","year":"2012","journal-title":"Clinical Microbiology Review"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1111\/j.1348-0421.2000.tb02557.x","article-title":"Canine ehrlichiosis caused simultaneously by Ehrlichia canis and Ehrlichia platys","volume":"44","year":"2000","journal-title":"Microbiology and Immunology"},{"key":"ref91","first-page":"45","article-title":"The situation of dog source in China","volume":"1","year":"2012","journal-title":"China Working Dog"},{"key":"ref301","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1128\/CMR.00012-12","article-title":"Human and animal dirofilariasis: the emergence of a zoonotic mosaic","volume":"25","year":"2012","journal-title":"Clinical Microbiology Review"},{"key":"ref161","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1089\/vbz.2010.0265","article-title":"Comparative evaluation of a point-of-care immunochromatographic test SNAP 4Dx with molecular detection tests for vector-borne canine pathogens in Hong Kong","volume":"11","year":"2011","journal-title":"Vector Borne and Zoonotic Diseases"},{"key":"ref371","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1186\/s13071-015-1120-y","article-title":"Molecular detection of vector-borne agents in dogs from ten provinces of China","volume":"8","year":"2015","journal-title":"Parasites & Vectors"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.tvjl.2010.02.001","article-title":"Diagnosis of canine monocytotropic ehrlichiosis (Ehrlichia canis): an overview","volume":"187","year":"2011","journal-title":"Veterinary Journal"},{"key":"ref311","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.vetpar.2011.04.023","article-title":"Babesiosis in dogs and cats-expanding parasitological and clinical spectra","volume":"181","year":"2011","journal-title":"Veterinary Parasitology"},{"key":"ref361","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1017\/S0022149X11000198","article-title":"The occurrence of Dirofilaria immitis, Borrelia burgdorferi, Ehrlichia canis and Anaplasma phagocytophilum in dogs in China","volume":"86","year":"2012","journal-title":"Journal of Helminthology"},{"key":"ref01","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.1128\/JCM.38.7.2778-2780.2000","article-title":"Identification of Ehrlichia chaffeensis by nested PCR in ticks from Southern China","volume":"38","year":"2000","journal-title":"Journal of Clinical Microbiology"},{"key":"ref251","doi-asserted-by":"crossref","first-page":"e53450","DOI":"10.1371\/journal.pone.0053450","article-title":"Ehrlichiosis, babesiosis, anaplasmosis and hepatozoonosis in dogs from St. Kitts, West Indies","volume":"8","year":"2013","journal-title":"PLoS One"},{"key":"ref121","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.vetpar.2011.04.023","article-title":"Babesiosis in dogs and cats-expanding parasitological and clinical spectra","volume":"181","year":"2011","journal-title":"Veterinary Parasitology"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"375","DOI":"10.3347\/kjp.2013.51.3.375","article-title":"Prevalence of Dirofilaria immitis in dogs in Shenyang, Northeastern China","volume":"51","year":"2013","journal-title":"Korean Journal of Parasitology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"937","DOI":"10.2460\/ajvr.1975.36.07.937","article-title":"Transmission of Ehrlichia canis to dogs by ticks (Rhipicephalus sanguineus)","volume":"36","year":"1975","journal-title":"American journal of Veterinary Research"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1590\/S1984-29612011000300002","article-title":"Brazilian canine hepatozoonosis","volume":"20","year":"2011","journal-title":"Revista brasileira de parasitologia veterin\u00e1ria"},{"key":"ref221","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.tvjl.2010.02.001","article-title":"Diagnosis of canine monocytotropic ehrlichiosis (Ehrlichia canis): an overview","volume":"187","year":"2011","journal-title":"Veterinary Journal"},{"key":"ref151","first-page":"21","article-title":"Molecular detection of Dirofilaria immitis, Hepatozoon canis, Babesia spp., Anaplasma platys and Ehrlichia canis in dogs on Costa Rica","volume":"60","year":"2014","journal-title":"Acta Parasitologica"},{"key":"ref201","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.2460\/ajvr.71.12.1443","article-title":"Performance of a commercially available in-clinic ELISA for the detection of antibodies against Anaplasma phagocytophilum, Ehrlichia canis, and Borrelia burgdorferi and Dirofilaria immitis antigen in dogs","volume":"71","year":"2010","journal-title":"American Journal of Veterinary Research"},{"key":"ref181","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1186\/s13071-015-1120-y","article-title":"Molecular detection of vector-borne agents in dogs from ten provinces of China","volume":"8","year":"2015","journal-title":"Parasites & Vectors"},{"key":"ref341","first-page":"21","article-title":"Molecular detection of Dirofilaria immitis, Hepatozoon canis, Babesia spp., Anaplasma platys and Ehrlichia canis in dogs on Costa Rica","volume":"60","year":"2014","journal-title":"Acta Parasitologica"},{"key":"ref141","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/S2221-1691(11)60201-3","article-title":"Serological investigation of vectorborne disease in dogs from rural areas of China","volume":"2","year":"2012","journal-title":"Asian Pacific journal of tropical biomedicine"},{"key":"ref211","doi-asserted-by":"crossref","first-page":"937","DOI":"10.2460\/ajvr.1975.36.07.937","article-title":"Transmission of Ehrlichia canis to dogs by ticks (Rhipicephalus sanguineus)","volume":"36","year":"1975","journal-title":"American journal of Veterinary Research"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1089\/vbz.2015.1898","article-title":"Detection of a novel Ehrlichia Species in Haemaphysalis longicornis tick from China","volume":"16","year":"2016","journal-title":"Vector Borne and Zoonotic Diseases"},{"key":"ref231","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.vetpar.2011.06.016","article-title":"Prevalence of Dirofilaria immitis infection in dogs from Dandong, China","volume":"183","journal-title":"Veterinary Parasitology"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"e53450","DOI":"10.1371\/journal.pone.0053450","article-title":"Ehrlichiosis, babesiosis, anaplasmosis and hepatozoonosis in dogs from St. Kitts, West Indies","volume":"8","year":"2013","journal-title":"PLoS One"},{"key":"ref321","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.vetpar.2011.09.035","article-title":"Serological survey of canine dirofilariosis in Chongqing, Kunming, Nanchang, Fuzhou, Guangzhou, Shenzhen, and Nanning in Southern China","volume":"185","year":"2012","journal-title":"Veterinary Parasitology"},{"key":"ref351","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1089\/vbz.2010.0265","article-title":"Comparative evaluation of a point-of-care immunochromatographic test SNAP 4Dx with molecular detection tests for vector-borne canine pathogens in Hong Kong","volume":"11","year":"2011","journal-title":"Vector Borne and Zoonotic Diseases"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.vetpar.2011.09.035","article-title":"Serological survey of canine dirofilariosis in Chongqing, Kunming, Nanchang, Fuzhou, Guangzhou, Shenzhen, and Nanning in Southern China","volume":"185","year":"2012","journal-title":"Veterinary Parasitology"},{"key":"ref291","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1590\/S1984-29612011000300002","article-title":"Brazilian canine hepatozoonosis","volume":"20","year":"2011","journal-title":"Revista brasileira de parasitologia veterin\u00e1ria"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.2460\/ajvr.71.12.1443","article-title":"Performance of a commercially available in-clinic ELISA for the detection of antibodies against Anaplasma phagocytophilum, Ehrlichia canis, and Borrelia burgdorferi and Dirofilaria immitis antigen in dogs","volume":"71","year":"2010","journal-title":"American Journal of Veterinary Research"},{"key":"ref241","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1111\/j.1348-0421.2000.tb02557.x","article-title":"Canine ehrlichiosis caused simultaneously by Ehrlichia canis and Ehrlichia platys","volume":"44","year":"2000","journal-title":"Microbiology and Immunology"},{"key":"ref281","first-page":"45","article-title":"The situation of dog source in China","volume":"1","year":"2012","journal-title":"China Working Dog"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.vetpar.2011.06.016","article-title":"Prevalence of Dirofilaria immitis infection in dogs from Dandong, China","volume":"183","journal-title":"Veterinary Parasitology"},{"key":"ref191","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.1128\/JCM.38.7.2778-2780.2000","article-title":"Identification of Ehrlichia chaffeensis by nested PCR in ticks from Southern China","volume":"38","year":"2000","journal-title":"Journal of Clinical Microbiology"},{"key":"ref331","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/S2221-1691(11)60201-3","article-title":"Serological investigation of vectorborne disease in dogs from rural areas of China","volume":"2","year":"2012","journal-title":"Asian Pacific journal of tropical biomedicine"},{"key":"ref171","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1017\/S0022149X11000198","article-title":"The occurrence of Dirofilaria immitis, Borrelia burgdorferi, Ehrlichia canis and Anaplasma phagocytophilum in dogs in China","volume":"86","year":"2012","journal-title":"Journal of Helminthology"},{"key":"ref271","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1089\/vbz.2015.1898","article-title":"Detection of a novel Ehrlichia Species in Haemaphysalis longicornis tick from China","volume":"16","year":"2016","journal-title":"Vector Borne and Zoonotic Diseases"}],"container-title":["Acta Parasitologica"],"original-title":[],"link":[{"URL":"http:\/\/www.degruyter.com\/view\/j\/ap.2018.63.issue-2\/ap-2018-0047\/ap-2018-0047.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.degruyter.com\/view\/j\/ap.2018.63.issue-2\/ap-2018-0047\/ap-2018-0047.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T17:41:13Z","timestamp":1751564473000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/doi\/10.1515\/ap-2018-0047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,26]]},"references-count":38,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1515\/ap-2018-0047","relation":{},"ISSN":["1896-1851","1230-2821"],"issn-type":[{"type":"electronic","value":"1896-1851"},{"type":"print","value":"1230-2821"}],"subject":[],"published":{"date-parts":[[2018,6,26]]}}}