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Expression of EBNA2 led to the transcriptional activation of both endogenous or transfected IFN-stimulated genes (ISGs), genes which contain within their promoters either the interferon-stimulated response element (ISRE) or the gamma interferon activation site (GAS). In search of a molecular mechanism for the transcriptional induction of ISGs, we observed an EBNA2-dependent synthesis of IFN-\u03b2 mRNA at low levels and the secretion of low amounts of IFN. A transfected IFN-\u03b2 promoter responded to EBNA2 activation, and a sequence closely resembling a RBP-J\u03ba binding site was pinpointed as a potential target of EBNA2 activity. EBNA2-dependent transcriptional induction of the IFN-\u03b2 promoter occurred in EBV-negative Burkitt's lymphoma cells, indicating that other EBV genes were not required for the induction of IFN-\u03b2 synthesis.<\/jats:p>","DOI":"10.1515\/bc.1999.029","type":"journal-article","created":{"date-parts":[[2004,9,29]],"date-time":"2004-09-29T11:59:46Z","timestamp":1096459186000},"source":"Crossref","is-referenced-by-count":19,"title":["The Epstein-Barr Virus Nuclear Antigen 2 (EBNA2), a Protein Required for B Lymphocyte Immortalization, Induces the Synthesis of Type I Interferon in Burkitts Lymphoma Cell Lines"],"prefix":"10.1515","volume":"380","author":[{"given":"K.","family":"Kanda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Kempkes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.W.","family":"Bornkamm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. von","family":"Gabain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Decker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"p_1","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1128\/JVI.64.5.2126-2134.1990","volume":"64","author":"Abbot S. 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