{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:05:58Z","timestamp":1791155158846,"version":"4.1.0"},"reference-count":34,"publisher":"Walter de Gruyter GmbH","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n            <jats:p>Kinins are potent vasoactive peptides generated in blood and tissues by the kallikrein serine proteases. Two distinct kinin receptors have been described, one constitutive (subtype B<jats:sub>2<\/jats:sub>) and one inducible (subtype B<jats:sub>1<\/jats:sub>), and many physiological functions have been attributed to these receptors, including glucose homeostasis and control of vascular permeability. In this study we show that mice lacking the kinin B<jats:sub>1<\/jats:sub> receptor (B<jats:sub>1<\/jats:sub>\n               <jats:sup>-\/-<\/jats:sup> mice) have lower fasting plasma glucose concentrations but exhibit higher glycemia after feeding when compared to wild-type mice. B<jats:sub>1<\/jats:sub>\n               <jats:sup>-\/-<\/jats:sup> mice also present pancreas abnormalities, characterized by fewer pancreatic islets and lower insulin content, which leads to hypoinsulinemia and reduced insulin release after a glucose load. Nevertheless, an insulin tolerance test indicated higher sensitivity in B<jats:sub>1<\/jats:sub>\n               <jats:sup>-\/-<\/jats:sup> mice. In line with this phenotype, pancreatic vascular permeability was shown to be reduced in B<jats:sub>1<\/jats:sub> receptor-ablated mice. The B<jats:sub>1<\/jats:sub> agonist desArg<jats:sup>9<\/jats:sup>bradykinin injected intravenously can induce the release of insulin into serum, and this effect was not observed in the B<jats:sub>1<\/jats:sub>\n               <jats:sup>-\/-<\/jats:sup> mice or in isolated islets. Our data demonstrate the importance of the kinin B<jats:sub>1<\/jats:sub> receptor in the control of pancreatic vascular homeostasis and insulin release, highlighting a new role for this receptor in the pathogenesis of diabetes and related diseases.<\/jats:p>","DOI":"10.1515\/bc.2006.057","type":"journal-article","created":{"date-parts":[[2006,4,11]],"date-time":"2006-04-11T15:56:01Z","timestamp":1144770961000},"page":"431-436","source":"Crossref","is-referenced-by-count":33,"title":["Role of the kinin B1 receptor in insulin homeostasis and pancreatic islet function"],"prefix":"10.1515","volume":"387","author":[{"given":"Ronaldo C.","family":"Ara\u00fajo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo A.","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa F.","family":"Merino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Loup","family":"Bascands","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost P.","family":"Schanstra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo L.","family":"Zollner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concei\u00e7\u00e3o A.","family":"Villela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clovis R.","family":"Nakaie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio C.M.","family":"Paiva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge L.","family":"Pesquero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Bader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o B.","family":"Pesquero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2001.014"},{"key":"ref2","first-page":"1","volume":"44","author":"Bhoola","year":"1992","journal-title":"Pharmacol. 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