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Here, we posed whether manual stimulation could also be beneficial after a surgical procedure potentially useful for treatment of large peripheral nerve defects, i.e., entubulation of the transected facial nerve in a conduit filled with suspension of isogeneic bone marrow-derived mesenchymal stem cells (BM-MSCs) in collagen. Compared to control treatment with collagen only, entubulation with BM-MSCs failed to decrease the extent of collateral axonal branching at the lesion site and did not improve functional recovery. Post-operative manual stimulation of vibrissal muscles also failed to promote a better recovery following entubulation with BM-MSCs. We suggest that BM-MSCs promote excessive trophic support for regenerating axons which, in turn, results in excessive collateral branching at the lesion site and extensive polyinnervation of the motor endplates. Furthermore, such deleterious effects cannot be overridden by manual stimulation. We conclude that entubulation with BM-MSCs is not beneficial for facial nerve repair.<\/jats:p>","DOI":"10.1515\/bc.2008.100","type":"journal-article","created":{"date-parts":[[2008,8,5]],"date-time":"2008-08-05T16:35:32Z","timestamp":1217954132000},"page":"873-888","source":"Crossref","is-referenced-by-count":15,"title":["Bone marrow-derived mesenchymal stem cell transplantation does not improve quality of muscle reinnervation or recovery of motor function after facial nerve transection in rats"],"prefix":"10.1515","volume":"389","author":[{"given":"Maria","family":"Grosheva","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, University of Cologne, D-50931 Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orlando","family":"Guntinas-Lichius","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Friedrich-Schiller University Jena, D-07740 Jena, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Arnhold","sequence":"additional","affiliation":[{"name":"Department of Veterinary Anatomy, Justus-Liebig-University, D-35392 Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanouil","family":"Skouras","sequence":"additional","affiliation":[{"name":"Department of Trauma, Hand and Reconstructive Surgery, University of Cologne, D-50931 Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefanie","family":"Kuerten","sequence":"additional","affiliation":[{"name":"Department of Anatomy I, University of Cologne, D-50931 Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Streppel","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, University of Cologne, D-50931 Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srebrina K.","family":"Angelova","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, University of Cologne, D-50931 Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantin","family":"Wewetzer","sequence":"additional","affiliation":[{"name":"Center of Anatomy, Hannover Medical School, Carl-Neuberg-Strasse 1, D-30625 Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Radtke","sequence":"additional","affiliation":[{"name":"Department of Plastic, Hand and Reconstructive Surgery, Hannover Medical School, D-30625 Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah A.","family":"Dunlop","sequence":"additional","affiliation":[{"name":"School of Animal Biology and Western Australian Institute for Medical Research, The University of Western Australia, Crawley 6009, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doychin N.","family":"Angelov","sequence":"additional","affiliation":[{"name":"Department of Anatomy I, University of Cologne, D-50931 Cologne, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2008,6,6]]},"reference":[{"key":"p_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.10102"},{"key":"p_2","doi-asserted-by":"crossref","first-page":"6623","DOI":"10.1523\/JNEUROSCI.22-15-06623.2002","volume":"22","author":"Akiyama Y.","year":"2002","journal-title":"J. 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