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Targeting of TBEV-NS5 to the plasma membrane is stabilised by ZO-1; however, DENV-NS5 co-localises with ZO-1 in the nucleus. These interactions have potential important roles in the ability of flaviviruses to manipulate cell proliferation, junction permeability and the interferon pathways.<\/jats:p>","DOI":"10.1515\/bc.2009.041","type":"journal-article","created":{"date-parts":[[2009,2,7]],"date-time":"2009-02-07T16:02:14Z","timestamp":1234022534000},"page":"319-323","source":"Crossref","is-referenced-by-count":40,"title":["Flavivirus NS5 associates with host-cell proteins zonula occludens-1 (ZO-1) and regulating synaptic membrane exocytosis-2 (RIMS2) via an internal PDZ binding mechanism"],"prefix":"10.1515","volume":"390","author":[{"given":"Karin","family":"Ellencrona","sequence":"first","affiliation":[{"name":"School of Life Sciences, S\u00f6dert\u00f6rn University, S-14189 Huddinge, Sweden and Department of Genetics, Microbiology and Toxicology, Stockholm University, S-106 91, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asim","family":"Syed","sequence":"additional","affiliation":[{"name":"School of Life Sciences, S\u00f6dert\u00f6rn University, S-14189 Huddinge, Sweden and Department of Biochemistry and Biophysics, Stockholm University, S-106 91, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Johansson","sequence":"additional","affiliation":[{"name":"School of Life Sciences, S\u00f6dert\u00f6rn University, S-14189 Huddinge, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2009,2,7]]},"reference":[{"key":"p_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M104248200"},{"key":"p_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200210020"},{"key":"p_3","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.20.12828-12839.2005"},{"key":"p_4","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M204977200"},{"key":"p_5","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-73-5-1125"},{"key":"p_6","doi-asserted-by":"publisher","DOI":"10.1038\/415327a"},{"key":"p_7","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.mi.44.100190.003245"},{"key":"p_8","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81307-0"},{"key":"p_9","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/21.11.2757"},{"key":"p_10","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.20.10779"},{"key":"p_11","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-3542(02)00206-1"},{"key":"p_12","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-3527(03)61008-0"},{"key":"p_13","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(01)00171-2"},{"key":"p_14","doi-asserted-by":"crossref","first-page":"3219","DOI":"10.1242\/jcs.114.18.3219","volume":"114","author":"Harris B.Z.","year":"2001","journal-title":"J. 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