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Atherosclerosis, a major cause of premature death, is initiated by pro-oxidative insults of the vascular endothelium. The strong antioxidant and activator of AhR bilirubin is generated in vascular endothelial cells, smooth muscles and macrophages. It acts mostly in the lipid environment, thereby complementing other antioxidants such as glutathione which act mostly on water-soluble proteins. In conclusion, the atheroprotective functions of bilirubin might not only provide models to study physiologic functions of the human AhR but also provide opportunities to improve prevention and treatment of a major life-threatening disease.<\/jats:p>","DOI":"10.1515\/bc.2010.065","type":"journal-article","created":{"date-parts":[[2010,4,7]],"date-time":"2010-04-07T02:24:18Z","timestamp":1270607058000},"source":"Crossref","is-referenced-by-count":23,"title":["Contributions of the Ah receptor to bilirubin homeostasis and its antioxidative and atheroprotective functions"],"prefix":"10.1515","volume":"391","author":[{"given":"Karl Walter","family":"Bock","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"K\u00f6hle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"p_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.107.07104"},{"key":"p_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2008.121269"},{"key":"p_3","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M108239200"},{"key":"p_4","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.37.26071"},{"key":"p_5","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.009886"},{"key":"p_6","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(69)90224-1"},{"key":"p_7","doi-asserted-by":"crossref","first-page":"14464","DOI":"10.1182\/blood.V93.5.1464","volume":"93","author":"Babior B.M.","year":"1999","journal-title":"Blood"},{"key":"p_8","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.252626999"},{"key":"p_9","doi-asserted-by":"publisher","DOI":"10.1002\/hlca.19540370139"},{"key":"p_10","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2008.12.004"},{"key":"p_11","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2009.138"},{"key":"p_12","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.108.026179"},{"key":"p_13","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.108.127043"},{"key":"p_14","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.108.024190"},{"key":"p_15","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.17.8185"},{"key":"p_16","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-002-0769-4"},{"key":"p_17","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M203161200"},{"key":"p_18","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M506683200"},{"key":"p_19","doi-asserted-by":"crossref","first-page":"H643","DOI":"10.1152\/ajpheart.2000.278.2.H643","volume":"278","author":"Clark J.E.","year":"2000","journal-title":"Am. 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