{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:41:53Z","timestamp":1760204513162},"reference-count":37,"publisher":"Walter de Gruyter GmbH","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n            <jats:p>Fanconi anemia (FA) is a rare cancer-prone genetic disorder characterized by progressive bone marrow failure, chromosomal instability and redox abnormalities. There is much biochemical and genetic data, which strongly suggest that FA cells experience increased oxidative stress. The present study was designed to elucidate if differences in oxidant state exist between control, idiopathic bone marrow failure (idBMF) and FA cells, and to analyze oxidant state of cells in FA heterozygous carriers as well. The results of the present study confirm an <jats:italic>in vivo<\/jats:italic> prooxidant state of FA cells and clearly indicate that FA patients can be distinguished from idBMF patients based on the oxidant state of cells. Female carriers of FA mutation also exhibited hallmarks of an <jats:italic>in vivo<\/jats:italic> prooxidant state behaving in a similar manner as FA patients. On the other hand, the oxidant state of cells in FA male carriers and idBMF families failed to show any significant difference vs. controls. We demonstrate that the altered oxidant state influences susceptibility of cells to apoptosis in both FA patients and female carriers. The results highlight the need for further research of the possible role of mitochondrial inheritance in the pathogenesis of FA.<\/jats:p>","DOI":"10.1515\/bc.2011.064","type":"journal-article","created":{"date-parts":[[2011,5,28]],"date-time":"2011-05-28T09:42:45Z","timestamp":1306575765000},"source":"Crossref","is-referenced-by-count":9,"title":["Gender-related differences in the oxidant state of cells in Fanconi anemia heterozygotes"],"prefix":"10.1515","volume":"392","author":[{"given":"Sandra","family":"Petrovic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreja","family":"Leskovac","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jelena","family":"Kotur-Stevuljevic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jelena","family":"Joksic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marija","family":"Guc-Scekic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dragana","family":"Vujic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordana","family":"Joksic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref431","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1093\/carcin\/14.6.1115","article-title":"and Increased formation of - hydroxydeoxyguanosine an oxidative DNA damage in lympho - blasts from Fanconi s anemia patients due to possible catalase deficiency","volume":"14","author":"Takeuchi","year":"1993","journal-title":"Carcinogenesis"},{"key":"ref251","first-page":"389","article-title":"Impaired synthesis of heme oxygenase - in Fanconi anemia cells can be rescued by transfection of Fanconi wild - type cDNA Law on Health Care Official Gazette of the Republic of Serbia Parliament of the Republic of Serbia No Belgrade","volume":"1","author":"Kontou","year":"2008","journal-title":"Biol Chem"},{"key":"ref341","first-page":"87","article-title":"Nitric oxide and peroxynitrite in health and disease","author":"Pacher","year":"2007","journal-title":"Physiol Rev"},{"key":"ref331","first-page":"303","article-title":"Effects of oxidative stress on the nuclear translocation of extracellular superoxide dismu - tase","author":"Ookawara","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"ref241","first-page":"384","article-title":"Suboptimal action of NF - kB in Fanconi anemia cells results from low levels of thioredoxin","author":"Kontou","year":"2003","journal-title":"Biol Chem"},{"key":"ref111","first-page":"89","article-title":"Fanconi s anemia cell lines show distinct mecha - nisms of cell death in response to mitomycin C or agonistic anti - Fas antibodies","author":"Clarke","year":"2004","journal-title":"Haematologica"},{"key":"ref461","first-page":"2008","article-title":"Biomarkers and mechanisms of FANCD function","author":"Willers","year":"2008","journal-title":"Biomed Biotechnol"},{"key":"ref171","first-page":"285","article-title":"The cytokinesis - block micronucleus technique : a detailed description of the method and its application to geno - toxicity studies in human populations Article in press - uncorrected proof Antioxidant status of Fanconi anemia fibroblasts","author":"Fenech","year":"1993","journal-title":"Mutat Res Hum Genet"},{"key":"ref421","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1182\/asheducation-2006.1.63","article-title":"Inherited bone marrow failure syndromes : molecular features Hematology Am Pro - gram","author":"Shimamura","year":"2006","journal-title":"Soc Hematol Educ"},{"key":"ref381","first-page":"288","article-title":"Peroxynitrite - induced membrane lipid peroxidation : the cyto - toxic potential of superoxide and nitric oxide","author":"Radi","year":"1991","journal-title":"Arch Biochem Biophys"},{"key":"ref11","first-page":"506","article-title":"Accelerated telomere shortening in Fanconi anemia fibroblasts a longitudinal study","author":"mann","year":"2001","journal-title":"FEBS Lett"},{"key":"ref451","first-page":"140","article-title":"Peroxyni - trite - induced cytotoxicity : mechanism and opportunities for intervention","author":"Virag","year":"2003","journal-title":"Toxicol Lett"},{"key":"ref391","first-page":"85","article-title":"Normal oxidative damage to mitochondrial and nuclear DNA is extensive Natl","author":"Richter","year":"1988","journal-title":"Proc Acad Sci USA"},{"key":"ref191","first-page":"195","article-title":"and The reaction of no with super - oxide Free Radic International Atomic Energy Agency ( IAEA ) Cytogenetic analysis for radiation dose assessment Technical Report Series No Vienna ISCN An International System for Cytogenetic Nomenclature Basel : Karger","volume":"18","author":"Huie","year":"1993","journal-title":"Res Commun"},{"key":"ref281","first-page":"402","article-title":"The p shc adaptor protein controls oxidative stress response and life span in mammals","volume":"66","author":"Migliaccio","year":"1999","journal-title":"Nature"},{"key":"ref201","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/35076590","article-title":"and The emerging genetic and molec - ular basis of Fanconi anaemia","volume":"2","author":"Joenje","year":"2001","journal-title":"Nat Rev Genet"},{"key":"ref371","first-page":"668","article-title":"and Fanconi anemia proteins and endogenous stresses","author":"Pang","year":"2009","journal-title":"Mutat Res"},{"key":"ref141","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.blre.2007.11.003","article-title":"and Inherited aplastic anaemias \/ bone marrow failure syndromes","volume":"22","author":"Dokal","year":"2008","journal-title":"Blood Rev"},{"key":"ref401","first-page":"99","article-title":"The role of oxygen metabolism for the pathological phe - notype of Fanconi anemia","author":"Ruppitsch","year":"1997","journal-title":"Hum Genet"},{"key":"ref121","first-page":"69","article-title":"and Gandini Effect of oxidants and antioxidants on chromosomal breakage in Fanconi anemia lymphocytes","author":"Dallapiccola","year":"1985","journal-title":"Hum Genet"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/mutage\/17.6.529","article-title":"The Fanconi anaemia genome sta - bility and tumour suppressor network","volume":"17","author":"Bogliolo","year":"2002","journal-title":"Mutagenesis"},{"key":"ref361","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1093\/carcin\/bgh194","article-title":"d Ischia Zat - et al Gender - and age - related distinctions for the in vivo prooxidant state in Fanconi anaemia patients","volume":"25","author":"Pagano","year":"2004","journal-title":"Carcinogenesis"},{"key":"ref101","first-page":"278","article-title":"Catalase activity is regulated by c - Abl and Arg in the oxidative stress response","author":"Cao","year":"2003","journal-title":"Biol Chem"},{"key":"ref411","first-page":"43","article-title":"and Fanconi anemia mutation caus - es cellular susceptibility to ambient oxygen","author":"Schindler","year":"1988","journal-title":"Am Hum Genet"},{"key":"ref211","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/S0140-6736(78)90632-3","article-title":"Erythrocyte superoxide - dismutase deficiency in Fan - coni s anaemia","volume":"1","author":"Joenje","year":"1978","journal-title":"Lancet"},{"key":"ref181","first-page":"391","article-title":"and Multiple protective functions of catalase against intercellular apoptosis - inducing ROS signal - ing of human tumor cells","author":"Heinzelmann","year":"2010","journal-title":"Biol Chem"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1002\/humu.10166","article-title":"et al Spectrum of sequence variation in the FANCG gene : an International Fanconi Anemia Registry IFAR ) study","volume":"21","author":"Auerbach","year":"2003","journal-title":"Hum Mutat"},{"key":"ref31","first-page":"248","article-title":"and Koliakos A novel assay for the evaluation of the prooxidant - antioxidant balance before and after antioxidant vitamin administration in type II diabetes patients Bio - chem","volume":"40","author":"Alamdari","year":"2007","journal-title":"Clin"},{"key":"ref441","first-page":"937","article-title":"Delayed formation of hydrogen peroxide mediates the lethal response evoked by peroxynitrite in U cells","author":"Tommasini","year":"2002","journal-title":"Mol Pharmacol"},{"key":"ref41","first-page":"77","article-title":"Oxidants stress induces the proto - oncogenes fos and C - myc in mouse epidermal cells Cancer Paris","author":"Amstad","year":"1990","journal-title":"Bull"},{"key":"ref311","first-page":"278","article-title":"and Malondialdehyde a product of lipid peroxidation is mutagenic in human cells","author":"Niedernhofer","year":"2003","journal-title":"Biol Chem"},{"key":"ref291","first-page":"247","article-title":"and The role of superoxide anion in the autoxidation of epinephrine and a simple assay for super - oxide dismutase","author":"Misra","year":"1972","journal-title":"Biol Chem"},{"key":"ref321","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1601-5223.1977.tb01223.x","article-title":"Effect of superoxide dismutase and catalase on spontaneously occurring chromosome breaks in patients with Fanconi s anemia","volume":"86","author":"Nordenson","year":"1977","journal-title":"Hereditas"},{"key":"ref261","first-page":"193","article-title":"Protein measurement with the Folin phenol reagent","author":"Lowry","year":"1951","journal-title":"Biol Chem"},{"key":"ref51","first-page":"258","article-title":"and Gut - teridge The mechanism of initiation of lipid peroxi - dation Evidence against a requirement for an iron ( II ) - iron ( III ) complex","author":"Aruoma","year":"1989","journal-title":"Biochem J"},{"key":"ref221","first-page":"290","article-title":"de Oxygen - dependence of chromosomal aberrations in Fanconi s anaemia","author":"Joenje","year":"1981","journal-title":"Nature"},{"key":"ref301","first-page":"175","article-title":"Defective mitochondrial peroxiredoxin - results in sensitivity to oxidative stress in Fan - coni anemia","volume":"3","author":"Mukhopadhyay","year":"2006","journal-title":"Cell Biol"}],"container-title":["Biological Chemistry"],"original-title":[],"link":[{"URL":"http:\/\/www.degruyter.com\/view\/j\/bchm.2011.392.issue-7\/bc.2011.064\/bc.2011.064.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/bc.2011.064\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T21:00:19Z","timestamp":1619038819000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/bc.2011.064\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,1]]},"references-count":37,"journal-issue":{"issue":"7"},"URL":"https:\/\/doi.org\/10.1515\/bc.2011.064","relation":{},"ISSN":["1437-4315","1431-6730"],"issn-type":[{"value":"1437-4315","type":"electronic"},{"value":"1431-6730","type":"print"}],"subject":[],"published":{"date-parts":[[2011,7,1]]}}}