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The optimized formulation consists of GB : PVPK30 = 1:10, PVPK30 as the carrier, and ethanol : dichloromethane = 1:1 as the solvent. They were treated ultrasonically for 10 min at 60\u00b0C. The results from scanning electron microscopy (SEM), differential scanning calorimetry (DSC), X-ray diffraction (XRD), and particle size analysis show that the morphological appearance of GB changed significantly in solid dispersion. The original crystal form of GB no longer existed, but it was uniformly dispersed within PVPK30 in a non-crystalline form. It is probably because the -C=O in GB forms hydrogen bonds with the -OH of PVPK30 or urea; this produces a nice solid dispersion and significantly improves the dissolution of GB in water. When GB is in a solid dispersion system, GB\u2019s dissolution in water could be enhanced from 30% to 80%. Furthermore, it may even be produced as a solid agent.<\/jats:p>","DOI":"10.1515\/biol-2018-0031","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T05:01:33Z","timestamp":1534914093000},"page":"253-262","source":"Crossref","is-referenced-by-count":7,"title":["Optimizing the Formulation for Ginkgolide B Solid Dispersion"],"prefix":"10.1515","volume":"13","author":[{"given":"Xiao","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Food Science , Beijing Union University , Beijing , 100023 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Huo","sequence":"additional","affiliation":[{"name":"Department of Biomedicine , Beijing Union University , Beijing , 100023 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qizhe","family":"Quan","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering , Beijing Union University , Beijing , 100023 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering , Beijing Union University , Beijing , 100023 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Engineering , Beijing Union University , Beijing , 100023 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Bioengineering , Beijing Union University , Beijing , 100023 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2018,8,21]]},"reference":[{"key":"2025122007345210477_j_biol-2018-0031_ref_001_w2aab2b8d263b1b7b1ab2b3b1Aa","unstructured":"Shi XL, Zhu Y, Yu JN, Xu XM. 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