{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T13:51:32Z","timestamp":1776779492966,"version":"3.51.2"},"reference-count":18,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,8,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"j_biol-2018-0032_s_005_w2aab2b8c36b1b7b1aab1c15b1Aa\">\n                    <jats:title>Object<\/jats:title>\n                    <jats:p>To summarize the etiology, pathology, diagnosis, clinical features, and treatment of the rare extranodal Rosai-Dorfman disease (RDD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_biol-2018-0032_s_006_w2aab2b8c36b1b7b1aab1c15b2Aa\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Clinical data of three cases of extranodal RDD who were admitted to the E. N. T. Department of the second hospital of Jilin University were analyzed retrospectively, and the literature was reviewed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_biol-2018-0032_s_007_w2aab2b8c36b1b7b1aab1c15b3Aa\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Three cases of extranodal RDD (maxillary sinus, nasal pharyngeal focus, and external auditory meatus) had a low fever and weight loss rather than painless enlarged lymph nodes. Surgical intervention was managed to clarify the diagnosis. All pathological diagnoses were extranodal RDD. Predisone for oral use was given to all patients postoperatively. There was no recurrence in the following 3 months, except case 1 was lost 2 months later.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_biol-2018-0032_s_008_w2aab2b8c36b1b7b1aab1c15b4Aa\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>RDD is a rare idiopathic histiocytic proliferative disorder defined by its unique histopathological features: a proliferation of huge histiocytic cells with emperipolesis and S-100(+), CD1a(-). RDD is characterized clinically by bilateral cervical painless enlarged lymph nodes, while extranodal RDD is rarer and its manifestations varied. A defined therapeutic regimen has not been elucidated. RDD in about 20% of patients is self-limited. Surgical intervention is the main management of treatment, with glucocorticoids used in initial medical therapy. More clinical trials are necessary before drawing conclusions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/biol-2018-0032","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T05:01:33Z","timestamp":1534914093000},"page":"263-268","source":"Crossref","is-referenced-by-count":2,"title":["Three Cases of Extranodal Rosai-Dorfman Disease and Literature Review"],"prefix":"10.1515","volume":"13","author":[{"given":"Xue","family":"Zhao","sequence":"first","affiliation":[{"name":"E.N.T.Department , the second hospital of Jilin University . Changchun City , Jilin Province , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Yu","sequence":"additional","affiliation":[{"name":"E.N.T.Department , the second hospital of Jilin University . Changchun City , Jilin Province , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunshun","family":"Jin","sequence":"additional","affiliation":[{"name":"E.N.T.Department , the second hospital of Jilin University . Changchun City , Jilin Province , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2018,8,21]]},"reference":[{"key":"2025122007345197488_j_biol-2018-0032_ref_001_w2aab2b8c36b1b7b1ab2b1b1Aa","unstructured":"Rosai J, Dorfman R. Sinus histiocytosis with massive lymphadenopathy: a newly recognized benign clinicopathological entity. Arch Pathol. 1969;87:63-70."},{"key":"2025122007345197488_j_biol-2018-0032_ref_002_w2aab2b8c36b1b7b1ab2b1b2Aa","doi-asserted-by":"crossref","unstructured":"Warpe BM, More SV. Rosai-Dorfman disease: A rare clinicopathological presentation. Australas Med J. 2014;7(2):68-72.","DOI":"10.4066\/AMJ.2014.1931"},{"key":"2025122007345197488_j_biol-2018-0032_ref_003_w2aab2b8c36b1b7b1ab2b1b3Aa","doi-asserted-by":"crossref","unstructured":"Dalia S, Sagatys E, Sokol L, Kubal T. Rosai-Dorfman disease: tumor biology, clinical features, pathology, and treatment. Cancer Control. 2014;21(4):322-7.","DOI":"10.1177\/107327481402100408"},{"key":"2025122007345197488_j_biol-2018-0032_ref_004_w2aab2b8c36b1b7b1ab2b1b4Aa","doi-asserted-by":"crossref","unstructured":"Garces S, Medeiros LJ, Patel KP, Li S, Pina-Oviedo S, Li J, et al. Mutually exclusive recurrent KRAS and MAP2K1 mutations in Rosai-Dorfman disease. Mod Pathol. 2017;30: 1367-77.","DOI":"10.1038\/modpathol.2017.55"},{"key":"2025122007345197488_j_biol-2018-0032_ref_005_w2aab2b8c36b1b7b1ab2b1b5Aa","unstructured":"Xu J, Zhang L. Extranodal Rosai-Dorfman disease: a clinicopathological analysis of three cases. 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