{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T11:28:37Z","timestamp":1745839717707},"reference-count":168,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2019,11,17]],"date-time":"2019-11-17T00:00:00Z","timestamp":1573948800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,11,17]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Venereal syphilis is a sexually transmitted disease caused by Treponema pallidum \u2013 Gram-negative, slowly growing bacteria. The spread of the disease in the Old World was due to increased birth rate, urban population growth, migration and lack of knowledge concerning the epidemiology. In the past, the treatment was mainly symptomatic and included application of mercury compounds. The goal of the study was to present the case of advanced venereal syphilis found in early modern (16th\u201318thc) graveyard localized in Wroclaw, Poland. The object of the study is a cranium of a male whose age at death has been estimated to be over 55. In order to observe the morphological and paleopathological characteristics of the examined material, anthropometrics, computed tomography, spectrometry and microscopic methods were incorporated. Microscopic analysis revealed the presence of the extensive inflammatory lesions. Analyses indicate tertiary stage of venereal syphilis as the most probable cause of the observed lesions. Concentration of arsenic (16.17\u00b10.58 \u03bcg\/g) in examined bone samples was about hundred times bigger than average arsenic concentration in bones reported in other studies. Advanced stage of observed lesions along with high arsenic level may suggest long-lasting palliative care and usage of arsenic compound in therapeutic treatment of this chronic disease.<\/jats:p>","DOI":"10.1515\/biol-2019-0048","type":"journal-article","created":{"date-parts":[[2019,11,17]],"date-time":"2019-11-17T09:02:31Z","timestamp":1573981351000},"page":"427-439","source":"Crossref","is-referenced-by-count":2,"title":["A case of syphilis with high bone arsenic concentration from early modern cemetery (Wroclaw, Poland)"],"prefix":"10.1515","volume":"14","author":[{"given":"Pawel","family":"Dabrowski","sequence":"first","affiliation":[{"name":"Department of Human Morphology and Embryology, Division of Normal Anatomy, Wroclaw Medical University, ul. Chalubinskiego 6a, 50-368Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal Jerzy","family":"Kulus","sequence":"additional","affiliation":[{"name":"Department of Human Morphology and Embryology, Division of Ultrastructure Research, Wroclaw Medical University, ul. Chalubinskiego 6a, 50-368Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agata","family":"Cieslik","sequence":"additional","affiliation":[{"name":"Department of Anthropology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences in Wroclaw, ul. Weigla 12, 53-114Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zygmunt","family":"Domagala","sequence":"additional","affiliation":[{"name":"Department of Human Morphology and Embryology, Division of Normal Anatomy, Wroclaw Medical University, ul. Chalubinskiego 6a, 50-368Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafa\u0142 J.","family":"Wiglusz","sequence":"additional","affiliation":[{"name":"Institute of Low Temperature and Structure Research, Polish Academy of Sciences, ul. Okolna 2, 50-422Wroclaw, Poland"},{"name":"Centre for Advanced Materials and Smart Structures, Polish Academy of Sciences, ul. Okolna 2, 50-422Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Kuropka","sequence":"additional","affiliation":[{"name":"Department of Histology, Wroclaw University of Environmental and Life Sciences, ul. Norwida 25, 50-375Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Kuryszko","sequence":"additional","affiliation":[{"name":"Department of Histology, Wroclaw University of Environmental and Life Sciences, ul. Norwida 25, 50-375Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agata","family":"Thannhauser","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine, Wroclaw Medical University, ul. Mikulicza-Radeckiego 4, 50-345Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukasz","family":"Szleszkowski","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine, Wroclaw Medical University, ul. Mikulicza-Radeckiego 4, 50-345Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr Marian","family":"Wojtulek","sequence":"additional","affiliation":[{"name":"Institute of Geological Sciences, University of Wroclaw, Pl. Borna 9, 50-205Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Solinski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Dziegiel","sequence":"additional","affiliation":[{"name":"Department of Human Morphology and Embryology, Division of Histology and Embryology, Wroclaw Medical University, ul. Chalubinskiego 6a, 50-368Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref631","volume-title":"Mieszka\u0144cy \u015bredniowiecznego Wroc\u0142awia. 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