{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T03:02:05Z","timestamp":1774148525923,"version":"3.50.1"},"reference-count":66,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T00:00:00Z","timestamp":1609372800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,12,31]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cirrhosis caused by viral and alcoholic hepatitis is an essential cause of portal hypertension (PHT). The incidence of PHT complication is directly proportional to portal venous pressure (PVP), and the clinical research of PVP and its hemodynamic indexes is of great significance for deciding the treatment strategy of PHT. Various techniques are currently being developed to decrease portal pressure but hemodynamic side effects may occur. In this article, the hemodynamic indexes of cirrhotic PHT patients were studied to explore the correlation between the index and PVP and to evaluate the clinical value of Doppler ultrasound in measuring PVP in patients with PHT. This was achieved by selecting 90 cirrhotic PHT patients who underwent transjugular intrahepatic portosystemic shunt in our hospital from June 2015 to September 2019. Fifty healthy people who had a physical examination in the hospital in the same period were selected as the control group. The liver hemodynamic parameters of two groups were measured by Doppler ultrasound, and the cirrhotic PHT patients were graded by the Child\u2013Pugh grading method to evaluate the liver function and measure the PVP value. The results showed that both the central portal vein velocity (PVV) and splenic vein velocity (SVV) of the PHT group were lower than those of the control group. Also, the portal vein diameter (PVD), portal venous flow and splenic vein diameter (SVD) were higher than those of the control group (all <jats:italic>P<\/jats:italic>s &lt; 0.05). Among liver function graded PHT patients, the PVD, PVV, SVD and SVV were significantly different (all <jats:italic>P<\/jats:italic>s &lt; 0.05). Furthermore, the PVP of patients with liver function grades A, B and C was 38.9 \u00b1 1.4, 40.6 \u00b1 5.1 and 42.5 \u00b1 4.8\u2009cmH<jats:sub>2<\/jats:sub>O, respectively, with a significant difference. It can be concluded from this study that Doppler ultrasound can be used as a tool for clinical assessment of PHT in cirrhosis patients. Doppler ultrasound showed a good prospect in noninvasive detection of PHT in cirrhosis; however, this technique needs application on large sample population study to validate the results.<\/jats:p>","DOI":"10.1515\/biol-2020-0101","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T01:02:07Z","timestamp":1610672527000},"page":"981-987","source":"Crossref","is-referenced-by-count":8,"title":["Relationship between hemodynamic parameters and portal venous pressure in cirrhosis patients with portal hypertension"],"prefix":"10.1515","volume":"15","author":[{"given":"Hongjuan","family":"Yao","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Xi\u2019an Gaoxin Hospital, Xi\u2019an, 710075, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongliang","family":"Wang","sequence":"additional","affiliation":[{"name":"Gerontological Surgery Department, Xi\u2019an International Medical Center, Xi\u2019an, 710100, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref61","doi-asserted-by":"crossref","first-page":"8","DOI":"10.5005\/jp-journals-10018-1157","article-title":"The evaluation of serum ascites albumin gradient and portal hypertensive changes in cirrhotic patients with ascites","volume":"6","year":"2016","journal-title":"Euroasian J Hepato-Gastroen"},{"key":"ref271","first-page":"1222","article-title":"Minocycline attenuates cirrhotic cardiomyopathy and portal hypertension in a rat model: Possible involvement of nitric oxide pathway","volume":"19","year":"2016","journal-title":"Iran J Basic Med Sci"},{"key":"ref331","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/1097-0096(200101)29:1<7::AID-JCU2>3.0.CO;2-V","article-title":"Color Doppler velocity profile assessment of portal hemodynamics in cirrhotic patients with portal hypertension: Correlation with esophageal variceal bleeding","volume":"29","year":"2001","journal-title":"J Clin Ultrasound"},{"key":"ref471","doi-asserted-by":"crossref","first-page":"6559","DOI":"10.3748\/wjg.v22.i28.6559","article-title":"Systemic mastocytosis: A rare cause of non-cirrhotic portal hypertension","volume":"22","year":"2016","journal-title":"World J Gastroen"},{"key":"ref441","doi-asserted-by":"crossref","first-page":"S710","DOI":"10.1016\/S0168-8278(16)01368-4","article-title":"Rivaroxaban reduces portal hypertension in cirrhotic rats by deactivating hepatic stellate cells and reducing intrahepatic microthrombosis","volume":"64","year":"2016","journal-title":"J Hepatol"},{"key":"ref591","first-page":"554","article-title":"Correlation between wedge hepatic vein pressure and portal vein pressure in 22 patients with liver cirrhosis","volume":"8","year":"2016","journal-title":"Chin J Digest"},{"key":"ref191","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.dld.2016.06.014","article-title":"Hepatic encephalopathy in patients with non-cirrhotic portal hypertension: Description, prevalence and risk factors","volume":"48","year":"2016","journal-title":"Dig Liver Dis"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"S710","DOI":"10.1016\/S0168-8278(16)01368-4","article-title":"Rivaroxaban reduces portal hypertension in cirrhotic rats by deactivating hepatic stellate cells and reducing intrahepatic microthrombosis","volume":"64","year":"2016","journal-title":"J Hepatol"},{"key":"ref141","doi-asserted-by":"crossref","first-page":"6559","DOI":"10.3748\/wjg.v22.i28.6559","article-title":"Systemic mastocytosis: A rare cause of non-cirrhotic portal hypertension","volume":"22","year":"2016","journal-title":"World J Gastroen"},{"key":"ref501","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/hep.28250","article-title":"Vasopressin 1a receptor partial agonism increases sodium excretion and reduces portal hypertension and ascites in cirrhotic rats","volume":"63","year":"2016","journal-title":"Hepatology"},{"key":"ref481","first-page":"310","article-title":"Diagnostic value of transient elastography for diagnosis of idiopathic non-cirrhotic portal hypertension","volume":"26","year":"2018","journal-title":"Chin J Hepatol"},{"key":"ref491","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1097\/MEG.0000000000001097","article-title":"Transjugular intrahepatic portosystemic shunt creation for cirrhotic portal hypertension is well tolerated among patients with portal vein thrombosis","volume":"30","year":"2018","journal-title":"Eur J Gastroen Hepatol"},{"key":"ref241","first-page":"56","article-title":"Orthotopic liver transplantation (OLTx) in non-cirrhotic portal hypertension secondary to ADAMTS13 deficiency","volume":"11","year":"2016","journal-title":"Prz Gastroenterol"},{"key":"ref321","first-page":"15296","article-title":"Association between D-dimer level and portal venous system thrombosis in liver cirrhosis: A retrospective observational study","volume":"8","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"ref171","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/hep.28250","article-title":"Vasopressin 1a receptor partial agonism increases sodium excretion and reduces portal hypertension and ascites in cirrhotic rats","volume":"63","year":"2016","journal-title":"Hepatology"},{"key":"ref521","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.dld.2016.06.014","article-title":"Hepatic encephalopathy in patients with non-cirrhotic portal hypertension: Description, prevalence and risk factors","volume":"48","year":"2016","journal-title":"Dig Liver Dis"},{"key":"ref611","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1097\/MEG.0000000000001067","article-title":"Ten-year experience of transjugular intrahepatic portosystemic shunt for noncirrhotic portal hypertension","volume":"30","year":"2018","journal-title":"Eur J Gastroen Hepatol"},{"key":"ref251","doi-asserted-by":"crossref","first-page":"688","DOI":"10.4254\/wjh.v7.i4.688","article-title":"Cirrhosis and portal hypertension: The importance of risk stratification, the role of hepatic venous pressure gradient measurement","volume":"7","year":"2015","journal-title":"World J Hepatol"},{"key":"ref351","doi-asserted-by":"crossref","first-page":"143","DOI":"10.21614\/chirurgia.112.2.143","article-title":"Cholecystolithotomy combined Armillarisin A versus cholecystectomy in cirrhotic portal hypertension patients with symptomatic cholelithiasis","volume":"112","year":"2017","journal-title":"Chirurgia"},{"key":"ref461","doi-asserted-by":"crossref","first-page":"S659","DOI":"10.1016\/S0168-8278(16)01238-1","article-title":"Favorable outcomes following tips in idiopathic non-cirrhotic portal hypertension with variceal bleeding: A case-control study from a single center","volume":"64","year":"2016","journal-title":"J Hepatol"},{"key":"ref371","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/MEG.0000000000000990","article-title":"Transjugular intrahepatic portosystemic shunt placement before abdominal intervention in cirrhotic patients with portal hypertension: Lessons from a pilot study","volume":"30","year":"2018","journal-title":"Eur J Gastroen Hepatol"},{"key":"ref211","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1053\/jlts.2003.50128","article-title":"Relationship between portal venous flow and liver regeneration in patients after living donor right-lobe liver transplantation","volume":"9","year":"2003","journal-title":"Liver Transplant"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"143","DOI":"10.21614\/chirurgia.112.2.143","article-title":"Cholecystolithotomy combined Armillarisin A versus cholecystectomy in cirrhotic portal hypertension patients with symptomatic cholelithiasis","volume":"112","year":"2017","journal-title":"Chirurgia"},{"key":"ref181","doi-asserted-by":"crossref","first-page":"142","DOI":"10.5005\/jp-journals-10018-1235","article-title":"Hepatic venous pressure gradient measurement in Bangladeshi Cirrhotic patients: A correlation with Child\u2019s status, variceal size, and bleeding","volume":"7","year":"2017","journal-title":"Euroasian J Hepato-gastroen"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"73","DOI":"10.4254\/wjh.v10.i1.73","article-title":"Collagen proportionate area correlates to hepatic venous pressure gradient in non-abstinent cirrhotic patients with alcoholic liver disease","volume":"10","year":"2018","journal-title":"World J Hepatol"},{"key":"ref391","doi-asserted-by":"crossref","first-page":"8","DOI":"10.5005\/jp-journals-10018-1157","article-title":"The evaluation of serum ascites albumin gradient and portal hypertensive changes in cirrhotic patients with ascites","volume":"6","year":"2016","journal-title":"Euroasian J Hepato-Gastroen"},{"key":"ref201","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0039-6109(16)45080-2","article-title":"Pathophysiology of portal hypertension and variceal bleeding","volume":"70","year":"1990","journal-title":"Surgical Clin North Am"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1097\/MEG.0000000000001097","article-title":"Transjugular intrahepatic portosystemic shunt creation for cirrhotic portal hypertension is well tolerated among patients with portal vein thrombosis","volume":"30","year":"2018","journal-title":"Eur J Gastroen Hepatol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/MEG.0000000000000990","article-title":"Transjugular intrahepatic portosystemic shunt placement before abdominal intervention in cirrhotic patients with portal hypertension: Lessons from a pilot study","volume":"30","year":"2018","journal-title":"Eur J Gastroen Hepatol"},{"key":"ref571","first-page":"56","article-title":"Orthotopic liver transplantation (OLTx) in non-cirrhotic portal hypertension secondary to ADAMTS13 deficiency","volume":"11","year":"2016","journal-title":"Prz Gastroenterol"},{"key":"ref311","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1002\/lt.21797","article-title":"Role of splanchnic hemodynamics in liver regeneration after living donor liver transplantation","volume":"15","year":"2009","journal-title":"Liver Transplant"},{"key":"ref581","doi-asserted-by":"crossref","first-page":"688","DOI":"10.4254\/wjh.v7.i4.688","article-title":"Cirrhosis and portal hypertension: The importance of risk stratification, the role of hepatic venous pressure gradient measurement","volume":"7","year":"2015","journal-title":"World J Hepatol"},{"key":"ref161","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1097\/MEG.0000000000001097","article-title":"Transjugular intrahepatic portosystemic shunt creation for cirrhotic portal hypertension is well tolerated among patients with portal vein thrombosis","volume":"30","year":"2018","journal-title":"Eur J Gastroen Hepatol"},{"key":"ref621","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1053\/jlts.2003.50069","article-title":"Changes in portal vein flow after adult living-donor liver transplantation: Does it influence postoperative liver function?","volume":"9","year":"2003","journal-title":"Liver Transplant"},{"key":"ref01","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/1097-0096(200101)29:1<7::AID-JCU2>3.0.CO;2-V","article-title":"Color Doppler velocity profile assessment of portal hemodynamics in cirrhotic patients with portal hypertension: Correlation with esophageal variceal bleeding","volume":"29","year":"2001","journal-title":"J Clin Ultrasound"},{"key":"ref101","first-page":"e57261","article-title":"Invasive hemodynamic characterization of the portal-hypertensive syndrome in cirrhotic rats","volume":"1","year":"2018","journal-title":"J Visualized Exp"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.dld.2016.06.014","article-title":"Hepatic encephalopathy in patients with non-cirrhotic portal hypertension: Description, prevalence and risk factors","volume":"48","year":"2016","journal-title":"Dig Liver Dis"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1080\/00034983.1994.11812896","article-title":"Propranolol reduces mortality in patients with portal hypertension secondary to schistosomiasis","volume":"88","year":"1994","journal-title":"Ann Tropical Med Parasitol"},{"key":"ref381","doi-asserted-by":"crossref","first-page":"73","DOI":"10.4254\/wjh.v10.i1.73","article-title":"Collagen proportionate area correlates to hepatic venous pressure gradient in non-abstinent cirrhotic patients with alcoholic liver disease","volume":"10","year":"2018","journal-title":"World J Hepatol"},{"key":"ref631","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1016\/j.transproceed.2008.01.074","article-title":"Correlation of portal venous velocity and portal venous flow with short-term graft regeneration in recipients of living donor liver transplants","volume":"40","year":"2008","journal-title":"Transplant Proc"},{"key":"ref511","doi-asserted-by":"crossref","first-page":"142","DOI":"10.5005\/jp-journals-10018-1235","article-title":"Hepatic venous pressure gradient measurement in Bangladeshi Cirrhotic patients: A correlation with Child\u2019s status, variceal size, and bleeding","volume":"7","year":"2017","journal-title":"Euroasian J Hepato-gastroen"},{"key":"ref641","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1002\/lt.21797","article-title":"Role of splanchnic hemodynamics in liver regeneration after living donor liver transplantation","volume":"15","year":"2009","journal-title":"Liver Transplant"},{"key":"ref291","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1053\/jlts.2003.50069","article-title":"Changes in portal vein flow after adult living-donor liver transplantation: Does it influence postoperative liver function?","volume":"9","year":"2003","journal-title":"Liver Transplant"},{"key":"ref531","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0039-6109(16)45080-2","article-title":"Pathophysiology of portal hypertension and variceal bleeding","volume":"70","year":"1990","journal-title":"Surgical Clin North Am"},{"key":"ref541","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1053\/jlts.2003.50128","article-title":"Relationship between portal venous flow and liver regeneration in patients after living donor right-lobe liver transplantation","volume":"9","year":"2003","journal-title":"Liver Transplant"},{"key":"ref601","first-page":"1222","article-title":"Minocycline attenuates cirrhotic cardiomyopathy and portal hypertension in a rat model: Possible involvement of nitric oxide pathway","volume":"19","year":"2016","journal-title":"Iran J Basic Med Sci"},{"key":"ref361","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.dld.2016.06.014","article-title":"Hepatic encephalopathy in patients with non-cirrhotic portal hypertension: Description, prevalence and risk factors","volume":"48","year":"2016","journal-title":"Dig Liver Dis"},{"key":"ref231","first-page":"152","article-title":"Non-cirrhotic portal hypertension associated with didanosine and Streptococcus agalactiae","volume":"11","year":"2016","journal-title":"infection: a case report. Rev Recent Clin Trials"},{"key":"ref151","first-page":"310","article-title":"Diagnostic value of transient elastography for diagnosis of idiopathic non-cirrhotic portal hypertension","volume":"26","year":"2018","journal-title":"Chin J Hepatol"},{"key":"ref551","first-page":"87","article-title":"Non-cirrhotic portal hypertension due to didanosina. A rare case","volume":"37","year":"2017","journal-title":"Rev de Gastroenterologia del Peru: Organo Oficial de la Soc de Gastroenterologia del Peru"},{"key":"ref561","first-page":"152","article-title":"Non-cirrhotic portal hypertension associated with didanosine and Streptococcus agalactiae","volume":"11","year":"2016","journal-title":"infection: a case report. Rev Recent Clin Trials"},{"key":"ref651","first-page":"15296","article-title":"Association between D-dimer level and portal venous system thrombosis in liver cirrhosis: A retrospective observational study","volume":"8","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"ref221","first-page":"87","article-title":"Non-cirrhotic portal hypertension due to didanosina. A rare case","volume":"37","year":"2017","journal-title":"Rev de Gastroenterologia del Peru: Organo Oficial de la Soc de Gastroenterologia del Peru"},{"key":"ref431","first-page":"e57261","article-title":"Invasive hemodynamic characterization of the portal-hypertensive syndrome in cirrhotic rats","volume":"1","year":"2018","journal-title":"J Visualized Exp"},{"key":"ref401","first-page":"17","article-title":"Influence of sustained viral response on the regression of fibrosis and portal hypertension in cirrhotic HCV patients treated with antiviral triple therapy","volume":"109","year":"2017","journal-title":"Rev Espa\u00f1ola de Enfermedades Digestivas"},{"key":"ref301","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1016\/j.transproceed.2008.01.074","article-title":"Correlation of portal venous velocity and portal venous flow with short-term graft regeneration in recipients of living donor liver transplants","volume":"40","year":"2008","journal-title":"Transplant Proc"},{"key":"ref421","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1097\/MEG.0000000000001097","article-title":"Transjugular intrahepatic portosystemic shunt creation for cirrhotic portal hypertension is well tolerated among patients with portal vein thrombosis","volume":"30","year":"2018","journal-title":"Eur J Gastroen Hepatol"},{"key":"ref121","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1016\/j.nano.2017.06.019","article-title":"Amelioration of cirrhotic portal hypertension by targeted cyclooxygenase-1 siRNA delivery to liver sinusoidal endothelium with polyethylenimine grafted hyaluronic acid","volume":"13","year":"2017","journal-title":"Nanomed: Nanotechnol Biol Med"},{"key":"ref131","doi-asserted-by":"crossref","first-page":"S659","DOI":"10.1016\/S0168-8278(16)01238-1","article-title":"Favorable outcomes following tips in idiopathic non-cirrhotic portal hypertension with variceal bleeding: A case-control study from a single center","volume":"64","year":"2016","journal-title":"J Hepatol"},{"key":"ref71","first-page":"17","article-title":"Influence of sustained viral response on the regression of fibrosis and portal hypertension in cirrhotic HCV patients treated with antiviral triple therapy","volume":"109","year":"2017","journal-title":"Rev Espa\u00f1ola de Enfermedades Digestivas"},{"key":"ref281","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1097\/MEG.0000000000001067","article-title":"Ten-year experience of transjugular intrahepatic portosystemic shunt for noncirrhotic portal hypertension","volume":"30","year":"2018","journal-title":"Eur J Gastroen Hepatol"},{"key":"ref451","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1016\/j.nano.2017.06.019","article-title":"Amelioration of cirrhotic portal hypertension by targeted cyclooxygenase-1 siRNA delivery to liver sinusoidal endothelium with polyethylenimine grafted hyaluronic acid","volume":"13","year":"2017","journal-title":"Nanomed: Nanotechnol Biol Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"317","DOI":"10.12659\/AOT.898253","article-title":"Portosystemic shunt surgery in patients with idiopathic noncirrhotic portal hypertension","volume":"21","year":"2016","journal-title":"Ann Transpl"},{"key":"ref411","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1080\/00034983.1994.11812896","article-title":"Propranolol reduces mortality in patients with portal hypertension secondary to schistosomiasis","volume":"88","year":"1994","journal-title":"Ann Tropical Med Parasitol"},{"key":"ref261","first-page":"554","article-title":"Correlation between wedge hepatic vein pressure and portal vein pressure in 22 patients with liver cirrhosis","volume":"8","year":"2016","journal-title":"Chin J Digest"},{"key":"ref341","doi-asserted-by":"crossref","first-page":"317","DOI":"10.12659\/AOT.898253","article-title":"Portosystemic shunt surgery in patients with idiopathic noncirrhotic portal hypertension","volume":"21","year":"2016","journal-title":"Ann Transpl"}],"container-title":["Open Life Sciences"],"original-title":[],"link":[{"URL":"https:\/\/www.degruyter.com\/view\/journals\/biol\/15\/1\/article-p981.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/downloadpdf\/journals\/biol\/15\/1\/article-p981.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,27]],"date-time":"2021-02-27T19:49:10Z","timestamp":1614455350000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/biol-2020-0101\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,31]]},"references-count":66,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1515\/biol-2020-0101","relation":{},"ISSN":["2391-5412"],"issn-type":[{"value":"2391-5412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,31]]}}}