{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:10:06Z","timestamp":1792599006222,"version":"4.5.0"},"reference-count":48,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T00:00:00Z","timestamp":1608681600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,12,23]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>C1q\/TNF-related protein 9 (CTRP9), the closest paralog of adiponectin, has been reported to protect against inflammation-related diseases. However, its role in regulating osteoarthritis (OA) has not been fully elucidated. First, a rat model of OA was generated. Furthermore, rats with OA were injected with different doses of recombinant CTRP9 protein (rCTRP9), and the knee cartilage damage was evaluated. Finally, the phosphorylation of p38 and the secretion of matrix metalloproteinases (MMPs) were detected by Western blotting and enzyme-linked immunosorbent assay. Results revealed that CTRP9 was highly expressed in adipose tissue, followed by skeletal muscle and cartilage tissue, and less expressed in liver, kidney and lung. Moreover, the expression of CTRP9 significantly decreased in the monosodium iodoacetate (MIA) group in the knee cartilage and knee synovial fluid, and the contents of interleukin-1\u03b2 (IL-1\u03b2) and IL-6 significantly increased in knee synovial fluid. In addition, rCTRP9 alleviated MIA-induced inflammation, oxidative stress and knee cartilage damage in a dose-dependent way. In addition, rCTRP9 could attenuate the expression of p38MAPK and p-p38 and suppress the expression of nuclear factor-kappa B (NF-\u03baB), p65 and MMPs. Collectively, the results of the present study suggested that CTRP9 alleviates the inflammation of MIA-induced OA through deactivating p38MAPK and NF-\u03baB signaling pathways in rats.<\/jats:p>","DOI":"10.1515\/biol-2020-0105","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T01:02:00Z","timestamp":1610672520000},"page":"971-980","source":"Crossref","is-referenced-by-count":20,"title":["CTRP9 protects against MIA-induced inflammation and knee cartilage damage by deactivating the MAPK\/NF-\u03baB pathway in rats with osteoarthritis"],"prefix":"10.1515","volume":"15","author":[{"given":"Shicheng","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Integrated TCM & Western Medicine Orthopaedics, Xi\u2019an Honghui Hospital, Xi\u2019an Jiaotong University, 555 of Youyi East Road, Xi\u2019an 710056, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Integrated TCM & Western Medicine Orthopaedics, Xi\u2019an Honghui Hospital, Xi\u2019an Jiaotong University, 555 of Youyi East Road, Xi\u2019an 710056, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sihai","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Integrated TCM & Western Medicine Orthopaedics, Xi\u2019an Honghui Hospital, Xi\u2019an Jiaotong University, 555 of Youyi East Road, Xi\u2019an 710056, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Integrated TCM & Western Medicine Orthopaedics, Xi\u2019an Honghui Hospital, Xi\u2019an Jiaotong University, 555 of Youyi East Road, Xi\u2019an 710056, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlong","family":"He","sequence":"additional","affiliation":[{"name":"Department of Integrated TCM & Western Medicine Orthopaedics, Xi\u2019an Honghui Hospital, Xi\u2019an Jiaotong University, 555 of Youyi East Road, Xi\u2019an 710056, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"ref191","doi-asserted-by":"crossref","first-page":"12532","DOI":"10.18632\/aging.102586","article-title":"Protease-activated receptor 2 (PAR-2) antagonist AZ3451 as a novel therapeutic agent for osteoarthritis","volume":"11","year":"2019","journal-title":"Aging"},{"key":"ref431","doi-asserted-by":"crossref","first-page":"12532","DOI":"10.18632\/aging.102586","article-title":"Protease-activated receptor 2 (PAR-2) antagonist AZ3451 as a novel therapeutic agent for 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