{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T00:35:15Z","timestamp":1784421315937,"version":"3.55.0"},"reference-count":51,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Several factors contribute to the development of breast cancer, including the immune system. This study is aimed to characterize the carriage of human leukocyte antigen (HLA)-DRB1*11 and 1*12 alleles in patients with breast cancer. This case-control study consisted of 96 histologically diagnosed breast cancer cases and 102 controls (cases without breast abnormalities). A multiplex polymerase chain reaction (PCR) was used to characterize the carriage of HLA-DRB1*11 and 1*12 alleles. The HLA-DRB1*11 allele was present in 26.59% of cases and 22.55% of controls. The HLA-DRB1*12 allele was present in 56.63% of cases and 55.88% of controls. This study found no direct association between the carriage of the HLA-DRB1*11 and HLA-DRB1*12 alleles and the occurrence of breast cancer. In addition, the deletion of the HLA-DRB1*11 allele is associated (beneficial effect) with obesity\/overweight (OR = 0.13; 95% CI [0.01\u20131.14]; and <jats:italic>p =<\/jats:italic> 0.03) which is a risk for breast cancer. No direct association was found between the carriage of HLA-DRB1*11 and 1*12 alleles and breast cancer risk. However, further investigation of other HLA alleles involved in the occurrence of breast cancer may provide more information.<\/jats:p>","DOI":"10.1515\/biol-2021-0113","type":"journal-article","created":{"date-parts":[[2021,10,14]],"date-time":"2021-10-14T03:31:14Z","timestamp":1634182274000},"page":"1101-1110","source":"Crossref","is-referenced-by-count":7,"title":["Carriage of HLA-DRB1*11 and 1*12 alleles and risk factors in patients with breast cancer in Burkina Faso"],"prefix":"10.1515","volume":"16","author":[{"given":"Abdou Azaque","family":"Zour\u00e9","sequence":"first","affiliation":[{"name":"Departement of Biochemistry and Microbiology, Laboratory of Molecular Biology and Genetics (LABIOGENE), UFR\/SVT, University Joseph KI-ZERBO , 03 P.O. Box 7021 , Ouagadougou 03 , Burkina Faso"},{"name":"Departement of Molecular Biology, Pietro Annigoni Biomolecular Research Center (CERBA) , 01 P.O. Box 364 , Ouagadougou 01 , Burkina Faso"},{"name":"Department of Biomedical and Public Health\/Institute of Health Sciences Research, (IRSS\/CNRST), Institute of Health Sciences Research , 03 BP 7192 , Ouagadougou 03 , Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanyo Jospin","family":"Amegnona","sequence":"additional","affiliation":[{"name":"Departement of Biochemistry and Microbiology, Laboratory of Molecular Biology and Genetics (LABIOGENE), UFR\/SVT, University Joseph KI-ZERBO , 03 P.O. Box 7021 , Ouagadougou 03 , Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayi","family":"Zongo","sequence":"additional","affiliation":[{"name":"Department of Surgery and Surgical Specialties, Service of General and Digestive Surgery, University Hospital Centre-Yalgado OUEDRAOGO, UFR\/SDS, University Joseph KI-ZERBO , 03 BP 7021 , Ouagadougou 03 , Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle Touwendpoulimd\u00e9","family":"Kiendrebeogo","sequence":"additional","affiliation":[{"name":"Departement of Biochemistry and Microbiology, Laboratory of Molecular Biology and Genetics (LABIOGENE), UFR\/SVT, University Joseph KI-ZERBO , 03 P.O. Box 7021 , Ouagadougou 03 , Burkina Faso"},{"name":"Departement of Molecular Biology, Pietro Annigoni Biomolecular Research Center (CERBA) , 01 P.O. Box 364 , Ouagadougou 01 , Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pegdwend\u00e9 Abel","family":"Sorgho","sequence":"additional","affiliation":[{"name":"Departement of Biochemistry and Microbiology, Laboratory of Molecular Biology and Genetics (LABIOGENE), UFR\/SVT, University Joseph KI-ZERBO , 03 P.O. Box 7021 , Ouagadougou 03 , Burkina Faso"},{"name":"Departement of Molecular Biology, Pietro Annigoni Biomolecular Research Center (CERBA) , 01 P.O. Box 364 , Ouagadougou 01 , Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabienne Ingrid","family":"Zongo","sequence":"additional","affiliation":[{"name":"Departement of Biochemistry and Microbiology, Laboratory of Molecular Biology and Genetics (LABIOGENE), UFR\/SVT, University Joseph KI-ZERBO , 03 P.O. Box 7021 , Ouagadougou 03 , Burkina Faso"},{"name":"Departement of Molecular Biology, Pietro Annigoni Biomolecular Research Center (CERBA) , 01 P.O. Box 364 , Ouagadougou 01 , Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert Th\u00e9ophane","family":"Yonli","sequence":"additional","affiliation":[{"name":"Departement of Biochemistry and Microbiology, Laboratory of Molecular Biology and Genetics (LABIOGENE), UFR\/SVT, University Joseph KI-ZERBO , 03 P.O. Box 7021 , Ouagadougou 03 , Burkina Faso"},{"name":"Departement of Molecular Biology, Pietro Annigoni Biomolecular Research Center (CERBA) , 01 P.O. Box 364 , Ouagadougou 01 , Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herman Karim","family":"Sombi\u00e9","sequence":"additional","affiliation":[{"name":"Departement of Biochemistry and Microbiology, Laboratory of Molecular Biology and Genetics (LABIOGENE), UFR\/SVT, University Joseph KI-ZERBO , 03 P.O. Box 7021 , Ouagadougou 03 , Burkina Faso"},{"name":"Departement of Molecular Biology, Pietro Annigoni Biomolecular Research Center (CERBA) , 01 P.O. Box 364 , Ouagadougou 01 , Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aboubacar Hierrhum","family":"Bambara","sequence":"additional","affiliation":[{"name":"Department of Medicine and Medical Specialties, Service of Oncology, University Hospital Centre-BOGODOGO, University Joseph KI-ZERBO, UFR\/SDS , 03 BP 7021 , Ouagadougou 03 , Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis Yobi","family":"Sawadogo","sequence":"additional","affiliation":[{"name":"Department of Gynecology-Obstetrics, Service of Gynecology, University Hospital Centre-BOGODOGO, University Joseph KI ZERBO, UFR\/SDS , 03 BP 7021 , Ouagadougou 03 , Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie N. L.","family":"Ouedraogo","sequence":"additional","affiliation":[{"name":"Departement of Biochemistry and Microbiology, Laboratory of Molecular Biology and Genetics (LABIOGENE), UFR\/SVT, University Joseph KI-ZERBO , 03 P.O. Box 7021 , Ouagadougou 03 , Burkina Faso"},{"name":"Departement of Molecular Biology, Pietro Annigoni Biomolecular Research Center (CERBA) , 01 P.O. Box 364 , Ouagadougou 01 , Burkina Faso"},{"name":"Faculty of Medicine, University Saint Thomas d\u2019Aquin , 06 BP 10212 , Ouagadougou 01 , Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lassina","family":"Traor\u00e9","sequence":"additional","affiliation":[{"name":"Departement of Biochemistry and Microbiology, Laboratory of Molecular Biology and Genetics (LABIOGENE), UFR\/SVT, University Joseph KI-ZERBO , 03 P.O. Box 7021 , Ouagadougou 03 , Burkina Faso"},{"name":"Departement of Molecular Biology, Pietro Annigoni Biomolecular Research Center (CERBA) , 01 P.O. Box 364 , Ouagadougou 01 , Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidnooma V\u00e9ronique","family":"Zongo","sequence":"additional","affiliation":[{"name":"Departement of Biochemistry and Microbiology, Laboratory of Molecular Biology and Genetics (LABIOGENE), UFR\/SVT, University Joseph KI-ZERBO , 03 P.O. Box 7021 , Ouagadougou 03 , Burkina Faso"},{"name":"Departement of Molecular Biology, Pietro Annigoni Biomolecular Research Center (CERBA) , 01 P.O. Box 364 , Ouagadougou 01 , Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doriane Tatiana","family":"Lallogo","sequence":"additional","affiliation":[{"name":"Departement of Biochemistry and Microbiology, Laboratory of Molecular Biology and Genetics (LABIOGENE), UFR\/SVT, University Joseph KI-ZERBO , 03 P.O. Box 7021 , Ouagadougou 03 , Burkina Faso"},{"name":"Departement of Molecular Biology, Pietro Annigoni Biomolecular Research Center (CERBA) , 01 P.O. Box 364 , Ouagadougou 01 , Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bapio Valery Jean T\u00e9lesphore Elvira","family":"Bazi\u00e9","sequence":"additional","affiliation":[{"name":"Departement of Biochemistry and Microbiology, Laboratory of Molecular Biology and Genetics (LABIOGENE), UFR\/SVT, University Joseph KI-ZERBO , 03 P.O. Box 7021 , Ouagadougou 03 , Burkina Faso"},{"name":"Departement of Molecular Biology, Pietro Annigoni Biomolecular Research Center (CERBA) , 01 P.O. Box 364 , Ouagadougou 01 , Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Th\u00e9odora M.","family":"Zohoncon","sequence":"additional","affiliation":[{"name":"Departement of Biochemistry and Microbiology, Laboratory of Molecular Biology and Genetics (LABIOGENE), UFR\/SVT, University Joseph KI-ZERBO , 03 P.O. 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Box 364 , Ouagadougou 01 , Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Simpore","sequence":"additional","affiliation":[{"name":"Departement of Biochemistry and Microbiology, Laboratory of Molecular Biology and Genetics (LABIOGENE), UFR\/SVT, University Joseph KI-ZERBO , 03 P.O. Box 7021 , Ouagadougou 03 , Burkina Faso"},{"name":"Departement of Molecular Biology, Pietro Annigoni Biomolecular Research Center (CERBA) , 01 P.O. Box 364 , Ouagadougou 01 , Burkina Faso"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2021,10,11]]},"reference":[{"key":"2022092006442087077_j_biol-2021-0113_ref_001","doi-asserted-by":"crossref","unstructured":"Sung H\n, \nFerlay J\n, \nSiegel RL\n, \nLaversanne M\n, \nSoerjomataram I\n, \nJemal A\n, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. 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