{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T12:34:56Z","timestamp":1768912496128,"version":"3.49.0"},"reference-count":28,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>High myopia is a common ocular genetic disease in the world. The study sought to investigate the effect of the Insulin-like growth factor-1 (IGF-1) and Matrix metalloproteinase-9 (MMP-9) genes polymorphisms on high myopia in a Han population of China. This study recruited 216 unrelated Han Chinese subjects, including 103 cases with high myopia and 113 controls. Four tagging single nucleotide polymorphisms (SNPs) of <jats:italic>IGF-1<\/jats:italic> and <jats:italic>MMP-9<\/jats:italic> genes were genotyped using the Sequenom MassARRAY method. The chi-square test showed that the family history was significantly correlated with myopia. The SNP genotypes were all in Hardy\u2013Weinberg equilibrium (<jats:italic>P<\/jats:italic> &gt; 0.05). Among the four SNPs, there were statistically significant differences in the genotype and allele frequencies of <jats:italic>rs2236416<\/jats:italic> between the groups (<jats:italic>P<\/jats:italic> = 0.024). The significant associations of <jats:italic>rs2236416<\/jats:italic> between cases and controls also appeared after Bonferroni multiple correction (<jats:italic>P<\/jats:italic> = 0.024). Then, there were significant differences in the genotypes dominant model and codominant model of <jats:italic>rs2236416<\/jats:italic> between groups (<jats:italic>P<\/jats:italic> = 0.007 and <jats:italic>P<\/jats:italic> = 0.004, respectively). <jats:italic>rs5742632<\/jats:italic> showed a significant difference between the cases and the controls in the recessive model (<jats:italic>P<\/jats:italic> = 0.037). Our findings indicated that <jats:italic>rs2236416<\/jats:italic> of <jats:italic>MMP-9<\/jats:italic> was associated with myopia in the population. The result suggested <jats:italic>MMP-9<\/jats:italic> gene locus may play a role in myopia.<\/jats:p>","DOI":"10.1515\/biol-2022-0055","type":"journal-article","created":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T23:19:18Z","timestamp":1652829558000},"page":"512-516","source":"Crossref","is-referenced-by-count":8,"title":["Genetic susceptibility to high myopia in Han Chinese population"],"prefix":"10.1515","volume":"17","author":[{"given":"Yufei","family":"Li","sequence":"first","affiliation":[{"name":"College of Life Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences , Tai\u2019an, 271016 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Continuous Education College, Shandong First Medical University & Shandong Academy of Medical Sciences , Tai\u2019an, 271016 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Infirmary, Shandong First Medical University & Shandong Academy of Medical Sciences , Tai\u2019an, 271016 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Gao","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences , Tai\u2019an, 271016 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingyue","family":"Ma","sequence":"additional","affiliation":[{"name":"Graduate School, Shandong First Medical University & Shandong Academy of Medical Sciences , Tai\u2019an, 271016 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Li","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Shandong University , Ji\u2019nan, 250100 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengxia","family":"Wang","sequence":"additional","affiliation":[{"name":"Ophthalmology Department, Tai\u2019an City Central Hospital , Tai\u2019an, 271000 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences , Tai\u2019an, 271016 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinye","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Basic Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences , Tai\u2019an, 271016 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Meng","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences , Tai\u2019an, 271016 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2022,5,17]]},"reference":[{"key":"2022120618362997830_j_biol-2022-0055_ref_001","doi-asserted-by":"crossref","unstructured":"Pan CW, Ramamurthy D, Saw SM. 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