{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T03:24:00Z","timestamp":1768706640813,"version":"3.49.0"},"reference-count":31,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,13]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The ancient Chinese remedy BuyangHuanwu Decoction (BHD) is used to treat qi deficit and blood stasis conditions. This work investigated the effect of BHD on cerebral vasospasm (CVS) caused by subarachnoid hemorrhage (SAH). Rats were randomly assigned into four groups: control group, SAH group, SAH + BHD [13\u2009g\/(kg\u2009day)] group, and SAH + BHD [26\u2009g\/(kg\u2009day)] group. The Garcia neurological scoring scale was used to assess neurological dysfunction. Hematoxylin and eosin stains were used to determine the extent of vasospasm by measuring the diameter of the basilar artery. Western blot was used to measure the concentrations of phosphoinositide 3-kinase (PI3K), AKT, and phospho-AKT expression levels. RT-PCR was used to determine PI3K and AKT RNA expressions. Immunohistochemistry and enzyme-linked immunosorbent assay were used to measure levels of endothelial nitric oxide synthase (eNOS) and nitric oxide (NO), respectively, in cerebrospinal fluid. BHD treatment ameliorated CVS and mitigated neurological dysfunction after SAH. Furthermore, the findings suggest that NO concentration was increased through the activation of classical PI3K\/AKT signaling and the eNOS pathway. Thus, BHD showed multifaceted roles in preventing damage via decreasing vasospasm and improving neurological impairments caused by CVS after SAH.<\/jats:p>","DOI":"10.1515\/biol-2022-0071","type":"journal-article","created":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T13:10:12Z","timestamp":1657717812000},"page":"735-743","source":"Crossref","is-referenced-by-count":4,"title":["BuyangHuanwu Decoction attenuates cerebral vasospasm caused by subarachnoid hemorrhage in rats via PI3K\/AKT\/eNOS axis"],"prefix":"10.1515","volume":"17","author":[{"given":"Weiping","family":"Li","sequence":"first","affiliation":[{"name":"The College of Life Sciences, Northwest University , Xi\u2019an 710069 , Shaanxi , China"},{"name":"Department of Neurology, The Second Affiliated Hospital of Shaanxi University of Chinese Medicine , Xianyang 712000 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ru","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Science and Technology Education, Dongguan Kanghua Hospital , Dongguan 523000 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychology, No. 923 Hospital of Joint Logistic Support Force of Chinese People\u2019s Liberation Army (PLA) , Nanning , 530000 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanfang","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital of Shaanxi University of Chinese Medicine , Xianyang 712000 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jumei","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Neurology, The Second Affiliated Hospital of Shaanxi University of Chinese Medicine , Xianyang 712000 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Tian","sequence":"additional","affiliation":[{"name":"The College of Life Sciences, Northwest University , Xi\u2019an 710069 , Shaanxi , China"},{"name":"Department of Medical Research Center, Northwest University Affiliated Hospital\/Xi\u2019an No. 3 Hospital , Xi\u2019an 710016 , Shaanxi , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2022,7,13]]},"reference":[{"key":"2022120618363506841_j_biol-2022-0071_ref_001","doi-asserted-by":"crossref","unstructured":"Mathers CD, Boerma T, Ma Fat D. 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