{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:08:36Z","timestamp":1787022516040,"version":"build-2736575974"},"reference-count":17,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study reports two cases of squamous cell carcinoma of the thyroid (SCCT) presenting as the thyroid goiter, involving one case of primary squamous cell carcinoma originating from the thyroid (PSCCT) and the other case of secondary SCCT of the thyroid. A retrospective analysis of the clinical and pathological findings was done in this study report. In case 1, the thyroid ultrasound showed multi-hypoechoic well-defined nodules, labeled as 3 using Thyroid Imaging Reporting and Data System, measuring 34.1\u2009mm \u00d7 28.9\u2009mm \u00d7 30.3\u2009mm and 26.5\u2009mm \u00d7 22.2\u2009mm \u00d7 23.9\u2009mm in the left in the right lobar thyroid, respectively. The patient underwent surgery and was histologically diagnosed with PSCCT. In case 2, the thyroid ultrasound showed a 25.2\u2009mm \u00d7 22.2\u2009mm \u00d7 18.8\u2009mm hypoechoic nodule in the right lobar thyroid. The patient underwent a frozen biopsy, the results of which increased suspicion of squamous cell carcinoma. A frozen biopsy was followed by an endoscopic evaluation that detected an ulcerative mass measuring 3.0\u2009cm within the mucosa of esophagus. Due to a scarcity of cases, SCCT is a great challenge for the pathologists and the managing team to come up with the best treatment strategy for the patients.<\/jats:p>","DOI":"10.1515\/biol-2022-0475","type":"journal-article","created":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T15:42:06Z","timestamp":1663342926000},"page":"1148-1154","source":"Crossref","is-referenced-by-count":5,"title":["Primary and metastatic squamous cell carcinoma of the thyroid gland: Two case reports"],"prefix":"10.1515","volume":"17","author":[{"given":"Xing","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Pathology, Affiliated Hospital of Chengde Medical College , Chengde , Hebei 067000 , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengyu","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of General Surgery IV , Baoding First Hospital, Zhonghua Road , Baoding , Hebei 071000 , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangbei","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of General Surgery IV , Baoding First Hospital, Zhonghua Road , Baoding , Hebei 071000 , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jirun","family":"Sun","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Pathology and Early Diagnosis of Tumor in Hebei Province , Baoding , Hebei , P.R. China"},{"name":"Department of Pathology, Baoding First Hospital , Baoding , Hebei 071000 , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of General Surgery I, CHENGDE County Traditional Chinese Medical Hospital , Chengde , Hebei 067000 , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhehui","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Fever Outpatient, CHENGDE County Traditional Chinese Medical Hospital , Chengde , Hebei 067000 , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libo","family":"Xin","sequence":"additional","affiliation":[{"name":"Department of General Surgery I, CHENGDE County Traditional Chinese Medical Hospital , Chengde , Hebei 067000 , P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmin","family":"Song","sequence":"additional","affiliation":[{"name":"Operation Room, CHENGDE County Traditional Chinese Medical Hospital , Chengde , Hebei 067000 , P.R. 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