{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T10:00:45Z","timestamp":1778320845794,"version":"3.51.4"},"reference-count":24,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Ewing\u2019s sarcoma (ES) is an aggressive cancer in young adults. Primary ES occurring in the chest with pleural effusion is even rarer. We report the case of a 15-year-old girl who presented with intermittent chest pain occurring for more than 2 months and cough and wheezing for 10 days. Radiological imaging showed a large soft tissue mass with multiple small vessel shadows near the left mediastinum and bloody pleural effusion in the left thorax. ES was diagnosed by positive immunostaining for CD99, FLI-1, and NKX2 combined with fluorescence <jats:italic>in situ<\/jats:italic> hybridization detection of the EWSR1 gene arrangement. With chemotherapy, lung computed tomography revealed that the tumor had become much smaller, and the fluid was absorbed. We report a case of extraskeletal Ewing\u2019s sarcoma (EES) in the mediastinum with pleural effusion, which is unusual and challenging. EES is a highly malignant tumor with a poor prognosis. Early diagnosis and treatment can improve the survival rate of patients.<\/jats:p>","DOI":"10.1515\/biol-2022-0669","type":"journal-article","created":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T13:50:51Z","timestamp":1690897851000},"source":"Crossref","is-referenced-by-count":5,"title":["Primary mediastinum Ewing\u2019s sarcoma with pleural effusion: A case report and literature review"],"prefix":"10.1515","volume":"18","author":[{"given":"Xuhong","family":"Li","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Zhongnan Hospital of Wuhan University , Wuhan 430071 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Zhongnan Hospital of Wuhan University , Wuhan 430071 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taiwen","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Zhongnan Hospital of Wuhan University , Wuhan 430071 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Zhongnan Hospital of Wuhan University , Wuhan 430071 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, Zhongnan Hospital of Wuhan University , Wuhan 430071 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2023,8,1]]},"reference":[{"key":"2023090109413438801_j_biol-2022-0669_ref_001","doi-asserted-by":"crossref","unstructured":"Sole A, Grossetete S, Heintze M, Babin L, Zaidi S, Revy P, et al. Unraveling Ewing sarcoma tumorigenesis originating from patient-derived mesenchymal stem cells. Cancer Res. 2021;81(19):4994\u20135006.","DOI":"10.1158\/0008-5472.CAN-20-3837"},{"key":"2023090109413438801_j_biol-2022-0669_ref_002","doi-asserted-by":"crossref","unstructured":"Haveman LM, van Ewijk R, van Dalen EC, Breunis WB, Kremer LC, van den Berg H, et al. High-dose chemotherapy followed by autologous haematopoietic cell transplantation for children, adolescents, and young adults with first recurrence of Ewing sarcoma. Cochrane Database Syst Rev. 2021;9(9):CD011406.","DOI":"10.1002\/14651858.CD011406.pub2"},{"key":"2023090109413438801_j_biol-2022-0669_ref_003","doi-asserted-by":"crossref","unstructured":"Sparreboom BD, Trautman J, Yaxley J. Ewing sarcoma: A pictorial review of typical and atypical locations with reference to the updated 2020 WHO classification system. J Med Imaging Radiat Oncol. 2022;66(6):812\u20138.","DOI":"10.1111\/1754-9485.13456"},{"key":"2023090109413438801_j_biol-2022-0669_ref_004","doi-asserted-by":"crossref","unstructured":"Abboud A, Masrouha K, Saliba M, Haidar R, Saab R, Khoury N, et al. Extraskeletal Ewing sarcoma: Diagnosis, management and prognosis. Oncol Lett. 2021;21(5):354.","DOI":"10.3892\/ol.2021.12615"},{"key":"2023090109413438801_j_biol-2022-0669_ref_005","doi-asserted-by":"crossref","unstructured":"Ghandour M, Lehner B, Klotz M, Geisbusch A, Bollmann J, Renkawitz T, et al. Extraosseous Ewing sarcoma in children: A systematic review and meta-analysis of clinicodemographic characteristics. Children (Basel). 2022;9(12):1859.","DOI":"10.3390\/children9121859"},{"key":"2023090109413438801_j_biol-2022-0669_ref_006","doi-asserted-by":"crossref","unstructured":"Jiang C, Peng X, Ye H, Zhang Y, Zheng K. FDG PET\/CT of primary Ewing sarcoma of the peritoneum. Clin Nucl Med. 2022;47(1):e4\u20135.","DOI":"10.1097\/RLU.0000000000003886"},{"key":"2023090109413438801_j_biol-2022-0669_ref_007","doi-asserted-by":"crossref","unstructured":"Shen G, Yi C, Pan L, Kuang A. Primary Ewing sarcoma of seminal vesicle on PET\/CT. Clin Nucl Med. 2021;46(5):422\u20133.","DOI":"10.1097\/RLU.0000000000003539"},{"key":"2023090109413438801_j_biol-2022-0669_ref_008","doi-asserted-by":"crossref","unstructured":"Riggi N, Suva ML, Stamenkovic I. Ewing\u2019s sarcoma. N Engl J Med. 2021;384(2):154\u201364.","DOI":"10.1056\/NEJMra2028910"},{"key":"2023090109413438801_j_biol-2022-0669_ref_009","doi-asserted-by":"crossref","unstructured":"Cidre-Aranaz F, Watson S, Amatruda JF, Nakamura T, Delattre O, de Alava E, et al. Small round cell sarcomas. Nat Rev Dis Primers. 2022;8(1):66.","DOI":"10.1038\/s41572-022-00393-3"},{"key":"2023090109413438801_j_biol-2022-0669_ref_010","doi-asserted-by":"crossref","unstructured":"Brahmi M, Vanacker H, Macagno N, Tirode F, Dufresne A. CIC-DUX4 sarcomas. Curr Opin Oncol. 2022;34(4):342\u20137.","DOI":"10.1097\/CCO.0000000000000855"},{"key":"2023090109413438801_j_biol-2022-0669_ref_011","doi-asserted-by":"crossref","unstructured":"Sbaraglia M, Righi A, Gambarotti M, Dei Tos AP. Ewing sarcoma and Ewing-like tumors. Virchows Arch. 2020;476(1):109\u201319.","DOI":"10.1007\/s00428-019-02720-8"},{"key":"2023090109413438801_j_biol-2022-0669_ref_012","doi-asserted-by":"crossref","unstructured":"Le Loarer F, Baud J, Azmani R, Michot A, Karanian M, Pissaloux D. Advances in the classification of round cell sarcomas. Histopathology. 2022;80(1):33\u201353.","DOI":"10.1111\/his.14547"},{"key":"2023090109413438801_j_biol-2022-0669_ref_013","doi-asserted-by":"crossref","unstructured":"Yu L, Davis IJ, Liu P. Regulation of EWSR1\u2013FLI1 function by post-transcriptional and post-translational modifications. Cancers (Basel). 2023;15(2):382.","DOI":"10.3390\/cancers15020382"},{"key":"2023090109413438801_j_biol-2022-0669_ref_014","doi-asserted-by":"crossref","unstructured":"Wright A, Desai M, Bolan CW, Badawy M, Guccione J, Rao Korivi B, et al. Extraskeletal Ewing sarcoma from head to toe: Multimodality imaging review. Radiographics. 2022;42(4):1145\u201360.","DOI":"10.1148\/rg.210226"},{"key":"2023090109413438801_j_biol-2022-0669_ref_015","doi-asserted-by":"crossref","unstructured":"Shulman DS, Whittle SB, Surdez D, Bailey KM, de Alava E, Yustein JT, et al. An international working group consensus report for the prioritization of molecular biomarkers for Ewing sarcoma. NPJ Precis. Oncol. 2022;6(1):65.","DOI":"10.1038\/s41698-022-00307-2"},{"key":"2023090109413438801_j_biol-2022-0669_ref_016","doi-asserted-by":"crossref","unstructured":"Eaton BR, Claude L, Indelicato DJ, Vatner R, Yeh B, Schwarz R, et al. Ewing sarcoma. Pediatr Blood Cancer. 2021;68(Suppl 2):e28355.","DOI":"10.1002\/pbc.28355"},{"key":"2023090109413438801_j_biol-2022-0669_ref_017","doi-asserted-by":"crossref","unstructured":"Laskar S, Sinha S, Chatterjee A, Khanna N, Manjali JJ, Puri A, et al. Radiation therapy dose escalation in unresectable Ewing sarcoma: Final results of a phase 3 randomized controlled trial. Int J Radiat Oncol Biol Phys. 2022;113(5):996\u20131002.","DOI":"10.1016\/j.ijrobp.2022.04.024"},{"key":"2023090109413438801_j_biol-2022-0669_ref_018","doi-asserted-by":"crossref","unstructured":"Tsetsou I, Moschouris H, Spanomanolis N, Soumpourou E. Ewing sarcoma of the lung: Imaging of a rare tumor. Cureus. 2022;14(12):e32395.","DOI":"10.7759\/cureus.32395"},{"key":"2023090109413438801_j_biol-2022-0669_ref_019","doi-asserted-by":"crossref","unstructured":"Cui M, Zhai D, Liu Y, Zhou X, Wang T, Wang L, et al. Case report: Primary mediastinal Ewing\u2019s sarcoma presenting with chest tightness. Front Oncol. 2022;12:1020339.","DOI":"10.3389\/fonc.2022.1020339"},{"key":"2023090109413438801_j_biol-2022-0669_ref_020","doi-asserted-by":"crossref","unstructured":"Zou X, Chang W, Gao H. A primary Ewing\u2019s sarcoma of pleura: Case report and literature review. Respir Med Case Rep. 2021;34:101516.","DOI":"10.1016\/j.rmcr.2021.101516"},{"key":"2023090109413438801_j_biol-2022-0669_ref_021","doi-asserted-by":"crossref","unstructured":"Ling X, Tong J, Wang L, Yao C, Chen Z. Primary pulmonary Ewing\u2019s sarcoma: Rare cause of massive hemothorax in a young girl-case report. BMC Pediatr. 2021;21(1):194.","DOI":"10.1186\/s12887-021-02672-6"},{"key":"2023090109413438801_j_biol-2022-0669_ref_022","doi-asserted-by":"crossref","unstructured":"Bhaskaran A, Sethi P, Toi PC, Penumadu P. Dilemma in diagnosis and management of rare primary pleural Ewing\u2019s sarcoma with synchronous limited metastatic disease. BMJ Case Rep. 2021;14(6):e243495.","DOI":"10.1136\/bcr-2021-243495"},{"key":"2023090109413438801_j_biol-2022-0669_ref_023","unstructured":"Karatziou C, Pitta X, Stergiouda T, Karadimou V, Termentzis G. A case of extraskeletal Ewing sarcoma originating from the visceral pleura. Hippokratia. 2011;15(4):363\u20135."},{"key":"2023090109413438801_j_biol-2022-0669_ref_024","doi-asserted-by":"crossref","unstructured":"Caltavituro A, Buonaiuto R, Salomone F, Morra R, Pietroluongo E, De Placido P, et al. Extraskeletal Ewing\u2019s sarcoma of the mediastinum: Case report. Front Oncol. 2023;13:1074378.","DOI":"10.3389\/fonc.2023.1074378"}],"container-title":["Open Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/biol-2022-0669\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/biol-2022-0669\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T10:12:28Z","timestamp":1693563148000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/biol-2022-0669\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,1]]},"references-count":24,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,6,14]]},"published-print":{"date-parts":[[2023,6,14]]}},"alternative-id":["10.1515\/biol-2022-0669"],"URL":"https:\/\/doi.org\/10.1515\/biol-2022-0669","relation":{},"ISSN":["2391-5412"],"issn-type":[{"value":"2391-5412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,1]]},"article-number":"20220669"}}