{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T16:12:47Z","timestamp":1780503167233,"version":"3.54.1"},"reference-count":24,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Rheumatoid arthritis (RA) is a chronic autoimmune disorder. Its pathogenesis is complicated but highly related to aberrant Th17 overactivation. Uncontrolled Th17 cell expansion and activation in populations and associated activities contribute to the progression of RA. Although clinical RA remedies are available, not all RA patients respond to these treatments, and adverse effects are always a concerning issue during treatment. To expand the repertoire of possible anti-RA remedies, we chose the phytochemical compound erianin, isolated from <jats:italic>Dendrobium<\/jats:italic> sp., and evaluated its antiarthritic effect <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic>. We found that erianin efficiently controlled the differentiation and activation of Th17 cell development from primary CD4 T cells, limiting IL-17A cytokine production and ROR\u03b3T transcript generation. In line with molecular docking models, the essential signaling pathway for Th17 polarization, the JAK\/STAT3 pathway, was inhibited upon erianin treatment, with dose-dependent inhibition of phosphorylation shown by western blotting. More importantly, erianin treatment reduced arthritic manifestations and proinflammatory cytokine levels in collagen-induced arthritis (CIA) mice, as well as protecting the joint histological microstructure. Overall, erianin revealed a promising inhibitory effect on Th17 overactivation and decreased disability in CIA mice. Therefore, erianin could be further developed as a candidate RA remedy.<\/jats:p>","DOI":"10.1515\/biol-2022-0703","type":"journal-article","created":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T16:18:55Z","timestamp":1693844335000},"source":"Crossref","is-referenced-by-count":6,"title":["Erianin alleviates collagen-induced arthritis in mice by inhibiting Th17 cell differentiation"],"prefix":"10.1515","volume":"18","author":[{"given":"Sen-Wei","family":"Tsai","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation , Taichung 427 , Taiwan"},{"name":"School of Medicine, Tzu Chi University , Hualien 970 , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jou-Hsuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Taichung Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation , Taichung 427 , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Kang","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Tungs\u2019 Taichung MetroHarbor Hospital , Taichung 435 , Taiwan"},{"name":"Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University , Taichung 402 , Taiwan"},{"name":"Department of Nursing, Jen-Teh Junior College of Medicine, Nursing and Management , Miaoli 356 , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Chen","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Science, National Chung Hsing University , Taichung , Taichung 402 , Taiwan"},{"name":"Department of Medical Research, China Medical University Hospital , Taichung 404 , Taiwan"},{"name":"Department of Medical Research, Taichung Veterans General Hospital , Taichung 407 , Taiwan"},{"name":"Department of Pharmacology, College of Medicine, Kaohsiung Medical University , Kaohsiung 807 , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2023,9,4]]},"reference":[{"key":"2023090416183159081_j_biol-2022-0703_ref_001","doi-asserted-by":"crossref","unstructured":"Yang P, Qian FY, Zhang MF, Xu AL, Wang X, Jiang BP, et al. Th17 cell pathogenicity and plasticity in rheumatoid arthritis. J Leukoc Biol. 2019;106:1233\u201340.","DOI":"10.1002\/JLB.4RU0619-197R"},{"key":"2023090416183159081_j_biol-2022-0703_ref_002","doi-asserted-by":"crossref","unstructured":"Van Hamburg JP, Asmawidjaja PS, Davelaar N, Mus AM, Colin EM, Hazes JM, et al. Th17 cells, but not Th1 cells, from patients with early rheumatoid arthritis are potent inducers of matrix metalloproteinases and proinflammatory cytokines upon synovial fibroblast interaction, including autocrine interleukin-17A production. Arthritis Rheum. 2011;63:73\u201383.","DOI":"10.1002\/art.30093"},{"key":"2023090416183159081_j_biol-2022-0703_ref_003","doi-asserted-by":"crossref","unstructured":"Le Goff B, Bouvard B, Lequerre T, Lespessailles E, Marotte H, Pers YM, et al. T implication of IL-17 in bone loss and structural damage in inflammatory rheumatic diseases. 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