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In this study, we aimed to identify novel genes associated with drug resistance and investigate their roles in BTZ resistance. Through the screening of 26 genes frequently associated with chemosensitivity or drug resistance, we discovered that KDM4C, a histone demethylase, exhibited increased expression in BTZ-resistant MM cells compared to their sensitive counterparts. Overexpression of <jats:italic>KDM4C<\/jats:italic> enhanced the tolerance of a MM cell line to the drug, whereas the knockdown of <jats:italic>KDM4C<\/jats:italic>, using shRNA, increased the sensitivity of resistant cells to BTZ treatment. This suggests that KDM4C plays a pivotal role in conferring BTZ resistance. Our study offers fresh insights into BTZ resistance in MM and highlights <jats:italic>KDM4C<\/jats:italic> as a potential target for overcoming drug resistance.<\/jats:p>","DOI":"10.1515\/biol-2022-0848","type":"journal-article","created":{"date-parts":[[2024,4,12]],"date-time":"2024-04-12T09:11:08Z","timestamp":1712913068000},"source":"Crossref","is-referenced-by-count":3,"title":["Identification of <i>KDM4C<\/i> as a gene conferring drug resistance in multiple myeloma"],"prefix":"10.1515","volume":"19","author":[{"given":"Na","family":"Zhang","sequence":"first","affiliation":[{"name":"Fujian Institute of Hematology, Fujian Provincial Key Laboratory on Hematology, Fujian Medical University Union Hospital , Fuzhou , 350001 , China"},{"name":"Fujian Medical University Center of Translational Hematology , Fuzhou , 350001 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruilong","family":"Lan","sequence":"additional","affiliation":[{"name":"Central Lab, The First Affiliated Hospital of Fujian Medical University , Fuzhou , 350005 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Fujian Institute of Hematology, Fujian Provincial Key Laboratory on Hematology, Fujian Medical University Union Hospital , Fuzhou , 350001 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianda","family":"Hu","sequence":"additional","affiliation":[{"name":"Fujian Institute of Hematology, Fujian Provincial Key Laboratory on Hematology, Fujian Medical University Union Hospital , Fuzhou , 350001 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2024,4,12]]},"reference":[{"key":"2024041209105874279_j_biol-2022-0848_ref_001","doi-asserted-by":"crossref","unstructured":"Kyle RA, Rajkumar SV. 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