{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T16:05:23Z","timestamp":1780589123251,"version":"3.54.1"},"reference-count":22,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We recruited four aquaporin-4 seropositive optic neuritis patients (five eyes) who received glucocorticoid treatment and underwent optical coherence tomography examination. Baseline medians of the macular ganglion cell layer plus inner plexiform layer (mGCIPL) thickness and volume for the eye of interest were 79.67\u2009\u00b5m (73.664 \u00b1 18.497\u2009\u00b5m) and 0.58 mm\n                    <jats:sup>3<\/jats:sup>\n                    (0.534 \u00b1 0.134 mm\n                    <jats:sup>3<\/jats:sup>\n                    ), respectively. At 2 months, the medians of the mGCIPL thickness and volume were 60.00\u2009\u00b5m (51.576 \u00b1 12.611\u2009\u00b5m) and 0.44 mm\n                    <jats:sup>3<\/jats:sup>\n                    (0.376 \u00b1 0.091 mm\n                    <jats:sup>3<\/jats:sup>\n                    ), respectively. At 6 months, the medians of the mGCIPL thickness and volume were 59.55\u2009\u00b5m (46.288 \u00b1 11.876\u2009\u00b5m) and 0.44 mm\n                    <jats:sup>3<\/jats:sup>\n                    (0.336 \u00b1 0.084 mm\n                    <jats:sup>3<\/jats:sup>\n                    ), respectively. Sample size estimate was achieved using two methods based on the mGCIPL thickness and volume data, with five effect sizes considered. The estimate based on the mGCIPL volume showed that 206 patients were needed at the 6-month follow-up; the power was 80% and effect size was 20%. In conclusion, this study detected retinal damage in aquaporin-4 seropositive optic neuritis patients by optical coherence tomography, and estimated the sample size for two-sample parallel designed clinical trials using two methods.\n                  <\/jats:p>","DOI":"10.1515\/biol-2022-0866","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T11:51:41Z","timestamp":1713268301000},"source":"Crossref","is-referenced-by-count":0,"title":["Sample size estimation for AQP4-IgG seropositive optic neuritis: Retinal damage detection by optical coherence tomography"],"prefix":"10.1515","volume":"19","author":[{"given":"Shuwen","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine , No. 19 Renmin Road , Zhengzhou 450099 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University , No. 1 Jianshe East Road , Zhengzhou 450052 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The First Affiliated Hospital of Guangxi Medical University , No. 6 Shuangyong Road , Nanning 530021 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2024,4,16]]},"reference":[{"key":"2026060415525014747_j_biol-2022-0866_ref_001","doi-asserted-by":"crossref","unstructured":"Zhou H, Xu Q, Zhao S, Wang W, Wang J, Chen Z, et al. 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