{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:52:18Z","timestamp":1753887138458,"version":"3.41.2"},"reference-count":16,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A congenital protein anomaly in the erythrocyte membrane skeleton causes a hereditary haemolytic illness known as hereditary spherocytosis (HS). The primary characteristic of HS is an increase in the number of tiny spherical red blood cells in the peripheral blood. The chief clinical features of HS include anaemia, jaundice, splenomegaly, spherical erythrocytosis in the blood, chronic anaemia with haemolysis, and recurrent acute attacks. Most patients have a family history; some have autosomal recessive inheritance, whereas most have autosomal dominant inheritance. In cases of severe hyperbilirubinemia disproportionate to haemolysis, other causes of hyperbilirubinemia should be considered. Gilbert syndrome (GS) is an autosomal dominant illness caused by the reduced activity of uridine diphosphate-glucuronosyl transferase lAl and is characterised by intermittent hyperbilirubinemia without any other signs or symptoms of liver disease. The possibility of the coexistence of HS and GS is very limited. Here we present the case of an elderly man with yellow skin and sclera recurring anaemia, and a final diagnosis of coexisting HS and GS.<\/jats:p>","DOI":"10.1515\/biol-2022-0904","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T21:33:44Z","timestamp":1719524024000},"source":"Crossref","is-referenced-by-count":0,"title":["Coexistence of hereditary spherocytosis with <i>SPTB P.Trp1150<\/i> gene variant and Gilbert syndrome: A case report and literature review"],"prefix":"10.1515","volume":"19","author":[{"given":"Changwei","family":"Chi","sequence":"first","affiliation":[{"name":"Department of Hematology, The Dingli Clinical College of Wenzhou Medical University (The Second Affiliated Hospital of Shanghai University, Wenzhou Central Hospital) , Wenzhou , Zhejiang , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shenghao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Dingli Clinical College of Wenzhou Medical University (The Second Affiliated Hospital of Shanghai University, Wenzhou Central Hospital) , Wenzhou , Zhejiang , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Dingli Clinical College of Wenzhou Medical University (The Second Affiliated Hospital of Shanghai University, Wenzhou Central Hospital) , Wenzhou , Zhejiang , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingying","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Dingli Clinical College of Wenzhou Medical University (The Second Affiliated Hospital of Shanghai University, Wenzhou Central Hospital) , Wenzhou , Zhejiang , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanwei","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Dingli Clinical College of Wenzhou Medical University (The Second Affiliated Hospital of Shanghai University, Wenzhou Central Hospital) , Wenzhou , Zhejiang , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanshan","family":"Weng","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Dingli Clinical College of Wenzhou Medical University (The Second Affiliated Hospital of Shanghai University, Wenzhou Central Hospital) , Wenzhou , Zhejiang , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2024,6,27]]},"reference":[{"key":"2024062716104584570_j_biol-2022-0904_ref_001","doi-asserted-by":"crossref","unstructured":"Lee MJ, Chang YH, Kang SH, Mun SK, Kim H, Han CJ, et al. A Case of hereditary spherocytosis coexisting with Gilbert\u2019s syndrome. Korean J Gastroenterol = Taehan Sohwagi Hakhoe chi. 2013;61(3):166\u20139.","DOI":"10.4166\/kjg.2013.61.3.166"},{"key":"2024062716104584570_j_biol-2022-0904_ref_002","doi-asserted-by":"crossref","unstructured":"He BJ, Liao L, Deng ZF, Tao YF, Xu YC, Lin FQ. Molecular genetic mechanisms of hereditary spherocytosis: Current perspectives. Acta Haematol. 2018;139(1):60\u20136.","DOI":"10.1159\/000486229"},{"key":"2024062716104584570_j_biol-2022-0904_ref_003","doi-asserted-by":"crossref","unstructured":"Wang R, Yang S, Xu M, Huang J, Liu H, Gu W, et al. Exome sequencing confirms molecular diagnoses in 38 Chinese families with hereditary spherocytosis. Sci China Life Sci. 2018;61(8):947\u201353.","DOI":"10.1007\/s11427-017-9232-6"},{"key":"2024062716104584570_j_biol-2022-0904_ref_004","doi-asserted-by":"crossref","unstructured":"Perrotta S, Gallagher PG, Mohandas N. Hereditary spherocytosis. 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