{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T22:29:05Z","timestamp":1757543345628,"version":"3.41.2"},"reference-count":24,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Otitis media (OM) is a prevalent childhood ear disease characterized by inflammation of the middle ear cavity, which can lead to ear pain, fever, and hearing loss. The pathogenesis of OM is multifaceted, encompassing a variety of factors including bacterial or viral infections, host immune responses, and the function of middle ear epithelial cells. Boswellic acid (BA), a natural triterpene compound extracted from frankincense resin, has been proven to possess significant anti-inflammatory and immunomodulatory effects. This study aims to investigate the effects of BA on lipopolysaccharide (LPS)-stimulated inflammatory responses and apoptosis in human middle ear epithelial cells (HMEECs) and its potential mechanisms. Our findings demonstrated that BA enhances the proliferation of LPS-stimulated HMEECs and concurrently inhibits their apoptosis. In addition, BA blocked LPS-stimulated HMEEC inflammation. Mechanistically, BA suppressed the NF-\u03baB\/I\u03baB\u03b1 axis in LPS-stimulated HMEECs. In conclusion, BA effectively inhibits LPS-stimulated inflammation and apoptosis by mediating the NF-\u03baB\/I\u03baB\u03b1 axis, highlighting its potential as a therapeutic agent for OM.<\/jats:p>","DOI":"10.1515\/biol-2022-1019","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T09:42:31Z","timestamp":1736761351000},"source":"Crossref","is-referenced-by-count":1,"title":["BA inhibits LPS-stimulated inflammatory response and apoptosis in human middle ear epithelial cells by regulating the Nf-Kb\/I\u03bab\u03b1 axis"],"prefix":"10.1515","volume":"19","author":[{"given":"Qian","family":"He","sequence":"first","affiliation":[{"name":"Department of ENT, Yueqing People\u2019s Hospital , 338, Qingyuan Road, Chengnan Street , Yueqing City, Wenzhou , Zhejiang, 325600 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanzhi","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of ENT, Yueqing People\u2019s Hospital , 338, Qingyuan Road, Chengnan Street , Yueqing City, Wenzhou , Zhejiang, 325600 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meihua","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of ENT, Yueqing People\u2019s Hospital , 338, Qingyuan Road, Chengnan Street , Yueqing City, Wenzhou , Zhejiang, 325600 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2024,12,31]]},"reference":[{"key":"2025011309405564496_j_biol-2022-1019_ref_001","doi-asserted-by":"crossref","unstructured":"Bharath J, Niti D, Chauhan S, Manoranjitha Kumari M, Sunitha VC, Nagarajan K. Fatal infratentorial subdural empyema due to chronic suppurative otitis media and mastoiditis in a young adult. Neurol India. 2024;72(1):182\u20135.","DOI":"10.4103\/neurol-india.Neurol-India-D-23-00066"},{"key":"2025011309405564496_j_biol-2022-1019_ref_002","doi-asserted-by":"crossref","unstructured":"Cao J, Liu W, Yang Z, Qu G, Zhong C. Causal relationship between body mass index and risk of otitis media with effusion in children: a mendelian randomization study. Indian J Otolaryngol Head Neck Surg. 2024;76(1):1410\u20138.","DOI":"10.1007\/s12070-023-04161-x"},{"key":"2025011309405564496_j_biol-2022-1019_ref_003","doi-asserted-by":"crossref","unstructured":"Kono M, Murakami D, Sakatani H, Okuda K, Kinoshita T, Hijiya M, et al. Factors affecting the antimicrobial changes during treatment for acute otitis media in Japan: a retrospective cohort study using classification and regression trees (CART) analysis. 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Influence of COVID-19 pandemic on otitis media with effusion in children: a multicenter, retrospective survey in northern Japan. Int J Pediatr Otorhinolaryngol. 2024;178:111904.","DOI":"10.1016\/j.ijporl.2024.111904"},{"key":"2025011309405564496_j_biol-2022-1019_ref_007","doi-asserted-by":"crossref","unstructured":"Sugino H, Tsumura S, Kunimoto M, Noda M, Chikuie D, Noda C, et al. Influence of pneumococcal conjugate vaccine on acute otitis media with severe middle ear inflammation: a retrospective multicenter study. PLoS One. 2015;10(9):e0137546.","DOI":"10.1371\/journal.pone.0137546"},{"key":"2025011309405564496_j_biol-2022-1019_ref_008","doi-asserted-by":"crossref","unstructured":"Kurabi A, Pak K, Ryan AF, Wasserman SI. Innate immunity: orchestrating inflammation and resolution of otitis media. 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Fisetin administration improves LPS-induced acute otitis media in mouse in vivo. Int J Mol Med. 2018;42(1):237\u201347.","DOI":"10.3892\/ijmm.2018.3585"},{"key":"2025011309405564496_j_biol-2022-1019_ref_018","doi-asserted-by":"crossref","unstructured":"Khaafi F, Javadi B. Molecular targets underlying the neuroprotective effects of boswellic acid: a systematic review. Mini Rev Med Chem. 2023;23(19):1912\u201325.","DOI":"10.2174\/1389557523666230330113611"},{"key":"2025011309405564496_j_biol-2022-1019_ref_019","doi-asserted-by":"crossref","unstructured":"Caterino C, Aragosa F, Della Valle G, Costanza D, Lamagna F, Piscitelli A, et al. Clinical efficacy of curcuvet and boswellic acid combined with conventional nutraceutical product: an aid to canine osteoarthritis. 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