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When the neuroinflammatory process is dysregulate, such as the over-activation of microglia, which results in the excessive accumulation of free oxygen and inflammatory factors in the brain, among other factors, it can lead to an imbalance in homeostasis and the development of various diseases. Recent research has indicated that the development of numerous neurodegenerative diseases is closely associated with neuroinflammation. The pathogenesis of neuroinflammation in the brain is intricate, involving alterations in numerous genes and proteins, as well as the activation and inhibition of signaling pathways. Furthermore, excessive inflammation can result in neuronal cell apoptosis, which can further exacerbate the extent of the disease. This article presents a summary of recent studies on the relationship between neuronal apoptosis caused by excessive neuroinflammation and neurodegenerative diseases. The aim is to identify the link between the two and to provide new ideas and targets for exploring the pathogenesis, as well as the prevention and treatment of neurodegenerative diseases.<\/jats:p>","DOI":"10.1515\/biol-2022-1051","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T03:54:57Z","timestamp":1740455697000},"source":"Crossref","is-referenced-by-count":30,"title":["Neurodegenerative diseases and neuroinflammation-induced apoptosis"],"prefix":"10.1515","volume":"20","author":[{"given":"Shi","family":"Huang","sequence":"first","affiliation":[{"name":"School of Clinical Medicine, Wannan Medical College , 241002 , Wuhu , Anhui , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxin","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Wannan Medical College , 241002 , Wuhu , Anhui , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanzhen","family":"Fang","sequence":"additional","affiliation":[{"name":"School of Stomatology, Wannan Medical College , 241002 , Wuhu , Anhui , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjiao","family":"Huang","sequence":"additional","affiliation":[{"name":"Human Anatomy Experimental Training Center, School of Basic Medical Science, Wannan Medical College , 241002 , Wuhu , Anhui , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Li","sequence":"additional","affiliation":[{"name":"Human Anatomy Experimental Training Center, School of Basic Medical Science, Wannan Medical College , 241002 , Wuhu , Anhui , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiliang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy, School of Basic Medical Science, Wannan Medical College , 241002 , Wuhu , Anhui , China"},{"name":"Anhui Province Key Laboratory of Basic Research and Translation of Aging-Related Diseases, Wannan Medical College , Wuhu , 241002, Anhui , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2025,2,25]]},"reference":[{"key":"2025122123390922824_j_biol-2022-1051_ref_001","doi-asserted-by":"crossref","unstructured":"Wilson DM, Cookson MR, Van Den Bosch L, Zetterberg H, Holtzman DM, Dewachter I. 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