{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,21]],"date-time":"2025-12-21T23:46:43Z","timestamp":1766360803655,"version":"3.48.0"},"reference-count":25,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Pleomorphic liposarcomas (PLPSs) commonly occur in the extremities or retroperitoneum. However, cases of primary PLPSs in the female reproductive system are rare, with only one reported case in the ovary. Herein, we describe the case of a patient with primary PLPS involving bilateral ovaries. She presented with a 2-month history of abdominal pain, and underwent total hysterectomy with bilateral salpingo-oophorectomy, omentectomy, and excision of surface lesions on the bladder and rectum. Intraoperatively, nitrogen mustard (2%) was used to rinse the abdominal cavity. One week postoperatively, she was administered the first cycle of postoperative cisplatin chemotherapy for intraperitoneal heat infusion chemotherapy plus intravenous liposomal paclitaxel. Postoperative histopathological examination revealed primary PLPS involving both ovaries. Therefore, a doxorubicin liposomal chemotherapy regimen was administered according to the soft tissue sarcoma NCCN guidelines. The patient\u2019s CA-125 levels decreased from 987 to 9.8\u2009U\/mL; however, after two chemotherapy sessions, she declined further treatment. The patient was still being followed-up and had no signs of recurrence at the time of writing this report. PLPS tends to be misdiagnosed and underdiagnosed due to its complex pathology and the lack of specific molecular markers. The disease is infrequent in the female reproductive system, and there is no consensus on its diagnostic and therapeutic guidelines. Herein, we summarized the findings of published case reports of PLPSs in organs of the female reproductive system to raise awareness of the disease and discussed its diagnosis, clinical treatment, and prognosis.<\/jats:p>","DOI":"10.1515\/biol-2025-1068","type":"journal-article","created":{"date-parts":[[2025,3,21]],"date-time":"2025-03-21T11:54:59Z","timestamp":1742558099000},"source":"Crossref","is-referenced-by-count":0,"title":["Primary pleomorphic liposarcoma involving bilateral ovaries: Case report and literature review"],"prefix":"10.1515","volume":"20","author":[{"given":"Huan","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Zhuzhou Central Hospital , Zhuzhou , 412000 , China"},{"name":"Department of Obstetrics and Gynecology, The Second XIANGYA Hospital of Central South University , Changsha , 410000 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The First People\u2019s Hospital of Jinghong , Jinghong , 666100 , China"},{"name":"Department of Obstetrics and Gynecology, The Second XIANGYA Hospital of Central South University , Changsha , 410000 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Second XIANGYA Hospital of Central South University , Changsha , 410000 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Puxiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Second XIANGYA Hospital of Central South University , Changsha , 410000 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2025,3,21]]},"reference":[{"key":"2025122123390925626_j_biol-2025-1068_ref_001","doi-asserted-by":"crossref","unstructured":"Kajita Y, Kato Jr T, Tamaki S, Furu M, Takahashi R, Nagayama S, et al. The transcription factor Sp3 regulates the expression of a metastasis-related marker of sarcoma, actin filament-associated protein 1-like 1 (AFAP1L1). PLoS One. 2013;8(1):e49709. 10.1371\/journal.pone.0049709. Epub 2013 Jan 9. PMID: 23326307; PMCID: PMC3541374.","DOI":"10.1371\/journal.pone.0049709"},{"key":"2025122123390925626_j_biol-2025-1068_ref_002","doi-asserted-by":"crossref","unstructured":"Taylor BS, DeCarolis PL, Angeles CV, Brenet F, Schultz N, Antonescu CR, et al. Frequent alterations and epigenetic silencing of differentiation pathway genes in structurally rearranged liposarcomas. Cancer Discov. 2011 Dec;1(7):587\u201397. 10.1158\/2159-8290.CD-11-0181. PMID: 22328974; PMCID: PMC3274776.","DOI":"10.1158\/2159-8290.CD-11-0181"},{"key":"2025122123390925626_j_biol-2025-1068_ref_003","unstructured":"WHO Classification of Tumours Editorial Board. Soft tissue and bone tumours. 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