{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:16:35Z","timestamp":1781828195823,"version":"3.54.5"},"reference-count":49,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,25]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    As sleep appears to be closely related to cognitive status, we aimed to explore the association between the percentage of deep sleep, cognitive state, and the cerebrospinal fluid (CSF) biomarker amyloid-beta 42 in non-demented individuals. In this cross-sectional study, 90 non-demented participants from the Aiginition Longitudinal Biomarker Investigation of Neurodegeneration cohort underwent a one-night WatchPAT sleep evaluation. Participants were categorized by cognitive status (patients with mild cognitive impairment [MCI] or cognitively normal [CN] individuals) and CSF A\u03b242 status (A\u03b242 \u2264 1,030\u2009pg\/mL [A+] or Ab42 &gt; 1,030\u2009pg\/mL [A\u2212]). After controlling for age, sex, and years of education, a significant inverse association was found between the percentage of deep sleep and the odds of being classified as MCI compared to CN (OR = 0.86, 95% CI [0.76\u20130.97],\n                    <jats:italic>p<\/jats:italic>\n                    = 0.012). However, a non-significant trend for an inverse association between the percentage of deep sleep and the odds of being classified as A+ was observed (OR = 0.92, 95% CI [0.84\u20131.01],\n                    <jats:italic>p<\/jats:italic>\n                    = 0.092). This study demonstrates a significant link between deep sleep and MCI. Although more longitudinal studies are needed, deep sleep could potentially serve as a novel biomarker of cognitive decline and an intervention target for dementia prevention.\n                  <\/jats:p>","DOI":"10.1515\/biol-2025-1077","type":"journal-article","created":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T01:51:19Z","timestamp":1743126679000},"source":"Crossref","is-referenced-by-count":2,"title":["Sleep architecture in Alzheimer\u2019s disease continuum: The deep sleep question"],"prefix":"10.1515","volume":"20","author":[{"given":"Ioannis","family":"Foukarakis","sequence":"first","affiliation":[{"name":"1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens Medical School , 11528 , Athens , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanos N.","family":"Sampatakakis","sequence":"additional","affiliation":[{"name":"1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens Medical School , 11528 , Athens , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eirini","family":"Mamalaki","sequence":"additional","affiliation":[{"name":"1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens Medical School , 11528 , Athens , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Kyrozis","sequence":"additional","affiliation":[{"name":"1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens Medical School , 11528 , Athens , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Ntanasi","sequence":"additional","affiliation":[{"name":"1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens Medical School , 11528 , Athens , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angeliki","family":"Tsapanou","sequence":"additional","affiliation":[{"name":"The Gertrude H. Sergievsky Center, Taub Institute for Research in Alzheimer\u2019s Disease and the Aging Brain, Department of Neurology, Columbia University , New York , NY, 10032 , United States of America"},{"name":"Department of Speech and Language Therapy, School of Health Rehabilitation Sciences, University of Patras , Patras , 26504 , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Yannakoulia","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, Harokopio University , 17671 Athens , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Rouskas","sequence":"additional","affiliation":[{"name":"Institute of Applied Biosciences, Centre for Research & Technology Hellas , 54124 Thessaloniki , Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Scarmeas","sequence":"additional","affiliation":[{"name":"1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens Medical School , 11528 , Athens , Greece"},{"name":"The Gertrude H. 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