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The concentration of 25\u2009\u00b5M Z-VA improved osteoblast differentiation by increasing the expression of Runx2 and type 1 collagen mRNA, alkaline phosphatase activity, and cellular calcium deposition. Dexamethasone-induced osteoporosis models were used in zebrafish and rats. In the zebrafish scale regeneration model, Z-VA decreased the hydroxyproline content and tartrate-resistant acid phosphatase activity while also upregulating the calcium to phosphorus molar ratio, Runx2a MASNA isoform, collagen2\u03b1, osteocalcin, and osteonectin. Additionally, Z-VA upregulated osteopontin and mitogen-activated protein kinase expression and downregulated matrix metalloproteinase 3 expression. Z-VA increased calcium deposition, callus formation, and bone growth in a zebrafish fracture model. In the rat model, Z-VA increased the bone transverse diameter, length, weight, mineral content, and mineral density, as well as serum Ca\n                    <jats:sup>2+<\/jats:sup>\n                    , inorganic phosphate, interleukin-6, tumor necrosis factor alpha, and alkaline phosphatase. Our results suggest that Z-VA may be an effective anti-osteoporotic agent that stimulates bone growth and prevents bone loss. However, further research is needed to elucidate its mechanisms and enhance its therapeutic application.\n                  <\/jats:p>","DOI":"10.1515\/biol-2025-1090","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T11:13:26Z","timestamp":1747221206000},"source":"Crossref","is-referenced-by-count":1,"title":["Zinc valproic acid complex promotes osteoblast differentiation and exhibits anti-osteoporotic potential"],"prefix":"10.1515","volume":"20","author":[{"given":"Huan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, Lequn Branch, The First Hospital of Jilin University , Changchun , Jilin, 130000 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, The 940th Hospital of Joint Logistics Support force of Chinese People\u2019s Liberation Army , Lanzhou , Gansu, 730070 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Lequn Branch, The First Hospital of Jilin University , Changchun , Jilin, 130000 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3401-6666","authenticated-orcid":false,"given":"Lingdi","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Joint Motion Spine, Shaoxing Central Hospital of Zhejiang Province , Shaoxing , Zhejiang, 312030 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2025,5,12]]},"reference":[{"key":"2025122123392400836_j_biol-2025-1090_ref_001","doi-asserted-by":"crossref","unstructured":"LeBoff MS, Greenspan SL, Insogna KL, Lewiecki EM, Saag KG, Singer AJ, et al. 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