{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,21]],"date-time":"2025-12-21T23:46:43Z","timestamp":1766360803062,"version":"3.48.0"},"reference-count":14,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Pulmonary cryptococcosis (PC) is an invasive fungal infection caused by\n                    <jats:italic>Cryptococcus neoformans<\/jats:italic>\n                    or\n                    <jats:italic>Cryptococcus gattii<\/jats:italic>\n                    . Its clinical presentation and radiological findings are often non-specific, making early diagnosis challenging. Herein, the case of a 44-year-old male who presented with dizziness and headache is reported. Initial cranial magnetic resonance imaging and chest computed tomography (plain and contrast-enhanced) suggested lung cancer with brain metastasis. A definitive diagnosis was established only after a lung mass biopsy, followed by a cytological smear and histopathological analysis, confirmed PC. The patient was treated with antifungal therapy postoperatively and responded well. This case underscores the importance of considering PC in differential diagnoses to enable prompt diagnosis and treatment, potentially reducing associated mortality.\n                  <\/jats:p>","DOI":"10.1515\/biol-2025-1119","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T08:57:06Z","timestamp":1754989026000},"source":"Crossref","is-referenced-by-count":0,"title":["Pulmonary cryptococcosis with headache as the first presentation: A case report"],"prefix":"10.1515","volume":"20","author":[{"given":"Ting","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Pathology, Zhejiang Provincial People\u2019s Hospital Bijie Hospital , Bijie , Guizhou , P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuai","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Pathology, Affiliated Hospital of Zunyi Medical University , Zunyi , Guizhou , P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2025,8,12]]},"reference":[{"key":"2025122123392414071_j_biol-2025-1119_ref_001","doi-asserted-by":"crossref","unstructured":"Tugume L, Ssebambulidde K, Kasibante J, Ellis J, Wake RM, Gakuru J, et al. Cryptococcal meningitis. Nat Rev Dis Primers. 2023;9(1):62.","DOI":"10.1038\/s41572-023-00472-z"},{"key":"2025122123392414071_j_biol-2025-1119_ref_002","doi-asserted-by":"crossref","unstructured":"Kajeekul R, Mekawichai P, Chayakulkeeree M. Clinical features of cryptococcal meningoencephalitis in HIV-positive and -negative patients in a resource-limited setting. J Fungi (Basel, Switzerland). 2023;9(9):869.","DOI":"10.3390\/jof9090869"},{"key":"2025122123392414071_j_biol-2025-1119_ref_003","doi-asserted-by":"crossref","unstructured":"Teixeira JC, de Oliveira VF, Gomes HR, Ribeiro SM, de Araujo EDMPA, da Cruz ICLV, et al. Association between neuroimaging and clinical outcomes in individuals with central nervous system cryptococcosis. Mycoses. 2024;67(7):e13767.","DOI":"10.1111\/myc.13767"},{"key":"2025122123392414071_j_biol-2025-1119_ref_004","doi-asserted-by":"crossref","unstructured":"Zhou Y, Huang X, Liu Y, Zhou Y, Zhou X, Liu Q. Destructive cryptococcal osteomyelitis mimicking tuberculous spondylitis. Am J Case Rep. 2024;25:e944291.","DOI":"10.12659\/AJCR.944291"},{"key":"2025122123392414071_j_biol-2025-1119_ref_005","doi-asserted-by":"crossref","unstructured":"Wang Y, Gu Y, Shen K, Cui X, Min R, Sun S, et al. Clinical features of cryptococcosis in patients with different immune statuses: a multicenter study in Jiangsu Province-China. BMC Infect Dis. 2021;21(1):1043.","DOI":"10.1186\/s12879-021-06752-x"},{"key":"2025122123392414071_j_biol-2025-1119_ref_006","doi-asserted-by":"crossref","unstructured":"Zhang YL, Ran C, Li W. Clinical imaging diagnosis of pulmonary cryptococcosis with different therapeutic responses. Sci Rep. 2024;14(1):29337.","DOI":"10.1038\/s41598-024-80875-4"},{"key":"2025122123392414071_j_biol-2025-1119_ref_007","doi-asserted-by":"crossref","unstructured":"Saag MS, Powderly WG, Cloud GA, Robinson P, Grieco MH, Sharkey PK, et al. Comparison of amphotericin B with fluconazole in the treatment of acute AIDS-associated cryptococcal meningitis. The NIAID Mycoses Study Group and the AIDS Clinical Trials Group. N Engl J Med. 1992;326(2):83\u20139.","DOI":"10.1056\/NEJM199201093260202"},{"key":"2025122123392414071_j_biol-2025-1119_ref_008","doi-asserted-by":"crossref","unstructured":"Skipper CP, Hullsiek KH, Stadelman A, Williams DA, Ssebambulidde K, Okafor E, et al. Sterile cerebrospinal fluid culture at cryptococcal meningitis diagnosis is associated with high mortality. J Fungi (Basel). 2022;9(1):46.","DOI":"10.3390\/jof9010046"},{"key":"2025122123392414071_j_biol-2025-1119_ref_009","doi-asserted-by":"crossref","unstructured":"Xie LM, Lin GL, Dong HN, Liao YX, Liu YL, Qin JF, et al. Evaluation of lateral flow immunochromatographic assay for diagnostic accuracy of cryptococcosis. BMC Infect Dis. 2020;20(1):650.","DOI":"10.1186\/s12879-020-05368-x"},{"key":"2025122123392414071_j_biol-2025-1119_ref_010","doi-asserted-by":"crossref","unstructured":"Jan IS, Cheng WC, Lo SC, Weng MH, Lee LN. Cryptococcus neoformans in sputum and lung aspiration cytology smears. J Microbiol, Immunol, Infect = Wei mian yu gan ran za zhi. 2015;48(4):463\u20134.","DOI":"10.1016\/j.jmii.2014.02.005"},{"key":"2025122123392414071_j_biol-2025-1119_ref_011","doi-asserted-by":"crossref","unstructured":"Howard-Jones AR, Sparks R, Pham D, Halliday C, Beardsley J, Chen SC. Pulmonary cryptococcosis. J Fungi (Basel). 2022;8(11):1156.","DOI":"10.3390\/jof8111156"},{"key":"2025122123392414071_j_biol-2025-1119_ref_012","doi-asserted-by":"crossref","unstructured":"Barros N, Wheat JL, Hage C. Pulmonary histoplasmosis: a clinical update. J Fungi (Basel). 2023;9(2):236.","DOI":"10.3390\/jof9020236"},{"key":"2025122123392414071_j_biol-2025-1119_ref_013","doi-asserted-by":"crossref","unstructured":"Belperio JA, Fishbein MC, Abtin F, Channick J, Balasubramanian SA, Lynch Iii JP. Pulmonary sarcoidosis: A comprehensive review: Past to present. J Autoimmun. 2024;149:103107.","DOI":"10.1016\/j.jaut.2023.103107"},{"key":"2025122123392414071_j_biol-2025-1119_ref_014","doi-asserted-by":"crossref","unstructured":"Zhou Y, Qiu B, Jiang J, Chen T, Wang L, Yang Y, et al. Case report: Experience and insights on the treatment of two cases of cryptococcal meningitis during the later stages of the COVID-19 pandemic. Front Immunol. 2024;15:1361277.","DOI":"10.3389\/fimmu.2024.1361277"}],"container-title":["Open Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/biol-2025-1119\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/biol-2025-1119\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,21]],"date-time":"2025-12-21T23:43:49Z","timestamp":1766360629000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/biol-2025-1119\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,1]]},"references-count":14,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,3,6]]},"published-print":{"date-parts":[[2025,3,6]]}},"alternative-id":["10.1515\/biol-2025-1119"],"URL":"https:\/\/doi.org\/10.1515\/biol-2025-1119","relation":{},"ISSN":["2391-5412"],"issn-type":[{"type":"electronic","value":"2391-5412"}],"subject":[],"published":{"date-parts":[[2025,1,1]]},"article-number":"20251119"}}