{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T10:11:20Z","timestamp":1767175880215,"version":"3.48.0"},"reference-count":33,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,1,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study aims to elucidate the intercellular communication mechanisms underlying T\u00a0cell infiltration in psoriatic skin. Single-cell RNA sequencing revealed increased proportions of endothelial cells and T\u00a0cells, alongside a reduction in melanocytes in psoriatic skin. Pseudotime analysis demonstrated dynamic transitions in T\u00a0cell states, with significant gene expression changes at key branching points. These genes were enriched in pathways related to the ribosome, cytoplasmic translation, and ribosomal structural components. Cell-cell communication analysis showed enhanced interactions, particularly between T\u00a0cells and fibroblasts in psoriasis. Fibroblasts exhibited upregulated MK signaling, characterized by elevated MDK expression and increased MDK receptor levels on T\u00a0cells, suggesting MDK-mediated T\u00a0cell recruitment. Regulatory network analysis identified IL-6 as a primary ligand regulating MDK\n                    <jats:italic>via<\/jats:italic>\n                    STAT3 and AHR, with increased expression of IL-6R, STAT3, and AHR in psoriatic fibroblasts. CuE treatment significantly alleviated psoriasis-like symptoms in a mouse model, as evidenced by reduced PASI scores, epidermal hyperplasia, and inflammatory cytokine levels. Mechanistically, CuE inhibited the STAT3\/MDK signaling pathway, indicating its role in modulating fibroblast-driven T\u00a0cell recruitment in psoriatic inflammation. This study demonstrates that CuE alleviates psoriasis-like symptoms by inhibiting the IL-6-STAT3-MDK signaling axis, positioning it as a potential novel therapeutic targeting fibroblast-mediated immune interactions in psoriasis.\n                  <\/jats:p>","DOI":"10.1515\/biol-2025-1231","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T10:07:16Z","timestamp":1767175636000},"source":"Crossref","is-referenced-by-count":0,"title":["Dissecting the molecular mechanisms of T\u00a0cell infiltration in psoriatic lesions\n                    <i>via<\/i>\n                    cell-cell communication and regulatory network analysis"],"prefix":"10.1515","volume":"20","author":[{"given":"Kexin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Dermatology , General Hospital of Ningxia Medical University , Yinchuan , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinhong","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Dermatology , General Hospital of Ningxia Medical University , Yinchuan , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Dermatology , General Hospital of Ningxia Medical University , Yinchuan , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaning","family":"Jiao","sequence":"additional","affiliation":[{"name":"Department of Dermatology , General Hospital of Ningxia Medical University , Yinchuan , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingdi","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Dermatology , General Hospital of Ningxia Medical University , Yinchuan , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingyao","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Dermatology , General Hospital of Ningxia Medical University , Yinchuan , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2025,12,31]]},"reference":[{"key":"2025123110070955281_j_biol-2025-1231_ref_001","doi-asserted-by":"crossref","unstructured":"Griffiths, CE, Barker, JN. 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