{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:09:00Z","timestamp":1787317740705,"version":"build-2736575974"},"reference-count":48,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We investigated the effects of hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) and sonic hedgehog (SHH) on the proliferation, autophagy, and apoptosis of human microvascular endothelial cells (HCMEC\/D3). We also explored the regulatory relationship between cystathionine-\u03b2-synthase (CBS) and the SHH pathway. Human microglia cells (HMC3) were stimulated under hypoxia to secrete H\n                    <jats:sub>2<\/jats:sub>\n                    S and SHH proteins, which were then co-cultured with HCMEC\/D3 cells. The relationship between H\n                    <jats:sub>2<\/jats:sub>\n                    S and SHH was investigated by inhibiting the CBS or SHH pathways. Vascular endothelial growth factor (VEGF) and H\n                    <jats:sub>2<\/jats:sub>\n                    S levels were detected using ELISA. The mRNA and Protein levels of VEGF, Beclin-1, light chain 3 (LC3), Cysteine aspartic acid protease-3(caspase-3), CBS, SHH, extracellular regulated kinase 1\/2 (ERK1\/2) and phospho-ERK1\/2 (P-ERK1\/2) were determined by RT-PCR and western blot. The results indicated that H\n                    <jats:sub>2<\/jats:sub>\n                    S secretion by HMC3 increased during hypoxia, with both CBS and SHH proteins being up-regulated. The inhibition of CBS resulted in decreased levels of H\n                    <jats:sub>2<\/jats:sub>\n                    S and SHH in HMC3. When the SHH pathway is inhibited, H\n                    <jats:sub>2<\/jats:sub>\n                    S secretion levels remain unaffected. H\n                    <jats:sub>2<\/jats:sub>\n                    S and SHH proteins increased VEGF, P-ERK1\/2, Beclin-1, and LC3 expression while reducing caspase-3 expression in HCMEC\/D3 cells. H\n                    <jats:sub>2<\/jats:sub>\n                    S secretion by HMC3 promotes the proliferation and regeneration of HCMEC\/D3 by regulating SHH protein and alleviating hypoxic injury.\n                  <\/jats:p>","DOI":"10.1515\/biol-2025-1242","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T11:03:35Z","timestamp":1769511815000},"source":"Crossref","is-referenced-by-count":1,"title":["Hydrogen sulfide promotes proliferation and regeneration of human cerebral microvascular endothelial cells via the sonic hedgehog signaling pathway"],"prefix":"10.1515","volume":"21","author":[{"given":"Hai-Yan","family":"Chen","sequence":"first","affiliation":[{"name":"The First Clinical Medical College of Jinan University , Guangzhou , 510000 , China"},{"name":"Department of Neurology , The Affiliated Hospital of Youjiang Medical University for Nationalities , Baise , 533000 , China"},{"name":"Key Laboratory of Research on Clinical Molecular Diagnosis for High Incidence Diseases in Western Guangxi of Guangxi Higher Education Institutions , Baise , 533000 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Min","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurology , The Affiliated Hospital of Youjiang Medical University for Nationalities , Baise , 533000 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology , The Affiliated Hospital of Youjiang Medical University for Nationalities , Baise , 533000 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui-Xin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology , The Affiliated Hospital of Youjiang Medical University for Nationalities , Baise , 533000 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing-Bing","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Neurology , The Affiliated Hospital of Youjiang Medical University for Nationalities , Baise , 533000 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Xue","family":"Zang","sequence":"additional","affiliation":[{"name":"Department of Neurology , The Affiliated Hospital of Youjiang Medical University for Nationalities , Baise , 533000 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nephrology , The Affiliated Hospital of Youjiang Medical University for Nationalities , Baise , 533000 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue-Bin","family":"Li","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College of Jinan University , Guangzhou , 510000 , China"},{"name":"Department of Neurology , The Affiliated Hospital of Youjiang Medical University for Nationalities , Baise , 533000 , China"},{"name":"Key Laboratory of Research on Clinical Molecular Diagnosis for High Incidence Diseases in Western Guangxi of Guangxi Higher Education Institutions , Baise , 533000 , China"},{"name":"Youjiang Medical University for Nationalities , Baise , 533000 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"key":"2026012711033092280_j_biol-2025-1242_ref_001","doi-asserted-by":"crossref","unstructured":"Ekker, MS, Verhoeven, JI, Vaartjes, I, Jolink, WMT, Klijn, CJM, de Leeuw, FE. Association of stroke among adults aged 18 to 49\u00a0years with long-term mortality. JAMA 2019;321:2113\u201323. https:\/\/doi.org\/10.1001\/jama.2019.6560.","DOI":"10.1001\/jama.2019.6560"},{"key":"2026012711033092280_j_biol-2025-1242_ref_002","doi-asserted-by":"crossref","unstructured":"Tapeinos, C, Gao, H, Bauleth-ramos, T, Santos, HA. Progress in stimuli-responsive biomaterials for treating cardiovascular and cerebrovascular diseases. Small 2022;18:e2200291. https:\/\/doi.org\/10.1002\/smll.202200291.","DOI":"10.1002\/smll.202200291"},{"key":"2026012711033092280_j_biol-2025-1242_ref_003","doi-asserted-by":"crossref","unstructured":"Haupt, M, Gerner, ST, B\u00e4HR, M, Doeppner, TR. Neuroprotective strategies for ischemic stroke-future perspectives. Int J Mol Sci 2023;24:4334. https:\/\/doi.org\/10.3390\/ijms24054334.","DOI":"10.3390\/ijms24054334"},{"key":"2026012711033092280_j_biol-2025-1242_ref_004","doi-asserted-by":"crossref","unstructured":"Dammavalam, V, Lin, S, Nessa, S, Daksla, N, Stefanowski, K, Costa, A, et al.. Neuroprotection during thrombectomy for acute ischemic stroke: a review of future therapies. Int J Mol Sci 2024;25:891. https:\/\/doi.org\/10.3390\/ijms25020891.","DOI":"10.3390\/ijms25020891"},{"key":"2026012711033092280_j_biol-2025-1242_ref_005","doi-asserted-by":"crossref","unstructured":"Paul, S, Candelario-jalil, E. Emerging neuroprotective strategies for the treatment of ischemic stroke: an overview of clinical and preclinical studies. Exp Neurol 2021;335:113518. https:\/\/doi.org\/10.1016\/j.expneurol.2020.113518.","DOI":"10.1016\/j.expneurol.2020.113518"},{"key":"2026012711033092280_j_biol-2025-1242_ref_006","doi-asserted-by":"crossref","unstructured":"Uniken Venema, SM, Dankbaar, JW, van der Lugt, A, Dippel, DWJ, van der Worp, HB. Cerebral collateral circulation in the era of reperfusion therapies for acute ischemic stroke. Stroke 2022;53:3222\u201334. https:\/\/doi.org\/10.1161\/STROKEAHA.121.037869.","DOI":"10.1161\/STROKEAHA.121.037869"},{"key":"2026012711033092280_j_biol-2025-1242_ref_007","doi-asserted-by":"crossref","unstructured":"Wu, H, Xia, C, Li, R, Tao, C, Tang, Q, Hu, W. Correlation between apelin and collateral circulation in patients with middle cerebral artery occlusion and moyamoya disease. Int J Gen Med 2022;19:699\u2013709. https:\/\/doi.org\/10.2147\/IJGM.S341015.","DOI":"10.2147\/IJGM.S341015"},{"key":"2026012711033092280_j_biol-2025-1242_ref_008","doi-asserted-by":"crossref","unstructured":"Cheng, K, Wang, Z, Bai, J, Xiong, J, Chen, J, Ni, J. Research advances in the application of vagus nerve electrical stimulation in ischemic stroke. Front Neurosci 2022;28:16:1043446. https:\/\/doi.org\/10.3389\/fnins.2022.1043446.","DOI":"10.3389\/fnins.2022.1043446"},{"key":"2026012711033092280_j_biol-2025-1242_ref_009","doi-asserted-by":"crossref","unstructured":"Bartkowiak, K, Bartkowiak, M, Jankowska-Steifer, E, Ratajska, A, Czarnowska, E, Kujawa, M, et al.. Expression of mRNA for molecules that regulate angiogenesis, endothelial cell survival, and vascular permeability is altered in endothelial cells isolated from db\/db mouse hearts. Histochem Cell Biol 2024;162:523\u201339. https:\/\/doi.org\/10.1007\/s00418-024-02327-4.","DOI":"10.1007\/s00418-024-02327-4"},{"key":"2026012711033092280_j_biol-2025-1242_ref_010","doi-asserted-by":"crossref","unstructured":"Wong, CWT, Sawhney, A, Wu, Y, Mak, YW, Tian, XY, Chan, HF, et al.. Sourcing of human peripheral blood-derived myeloid angiogenic cells under xeno-free conditions for the treatment of critical limb ischemia. Stem Cell Res Ther 2022;13:419. https:\/\/doi.org\/10.1186\/s13287-022-03095-5.","DOI":"10.1186\/s13287-022-03095-5"},{"key":"2026012711033092280_j_biol-2025-1242_ref_011","doi-asserted-by":"crossref","unstructured":"Huang, Y, Omorou, M, Gao, M, Mu, C, Xu, W, Xu, H. Hydrogen sulfide and its donors for the treatment of cerebral ischaemia-reperfusion injury: a comprehensive review. Biomed Pharmacother 2023;161:114506. https:\/\/doi.org\/10.1016\/j.biopha.2023.114506.","DOI":"10.1016\/j.biopha.2023.114506"},{"key":"2026012711033092280_j_biol-2025-1242_ref_012","doi-asserted-by":"crossref","unstructured":"Wang, YZ, Ngowi, EE, Wang, D, Qi, HW, Jing, MR, Zhang, YX, et al.. The potential of hydrogen sulfide donors in treating cardiovascular diseases. Int J Mol Sci 2021;22:2194. https:\/\/doi.org\/10.3390\/ijms22042194.","DOI":"10.3390\/ijms22042194"},{"key":"2026012711033092280_j_biol-2025-1242_ref_013","doi-asserted-by":"crossref","unstructured":"Tikhomirova, I, Muravyov, A. Hydrogen sulfide in the cardiovascular system: a small molecule with promising therapeutic potential. J\u00a0Cell Biotechnol 2023;23:93\u2013115. https:\/\/doi.org\/10.3233\/jcb-230098.","DOI":"10.3233\/JCB-230098"},{"key":"2026012711033092280_j_biol-2025-1242_ref_014","doi-asserted-by":"crossref","unstructured":"Zhang, YX, Jing, MR, Cai, CB, Zhu, SG, Zhang, CJ, Wang, QM, et al.. Role of hydrogen sulphide in physiological and pathological angiogenesis. Cell Prolif 2023;56:e13374. https:\/\/doi.org\/10.1111\/cpr.13374.","DOI":"10.1111\/cpr.13374"},{"key":"2026012711033092280_j_biol-2025-1242_ref_015","doi-asserted-by":"crossref","unstructured":"Cirino, G, Szabo, C, Papapetropoulos, A. Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs. Physiol Rev 2023;103:31\u2013276. https:\/\/doi.org\/10.1152\/physrev.00028.2021.","DOI":"10.1152\/physrev.00028.2021"},{"key":"2026012711033092280_j_biol-2025-1242_ref_016","doi-asserted-by":"crossref","unstructured":"Wang, X, Fan, W, Li, N, Ma, Y, Yao, M, Wang, G, et al.. YY1 lactylation in microglia promotes angiogenesis through transcription activation-mediated upregulation of FGF2. Genome Biol 2023;24:87. https:\/\/doi.org\/10.1186\/s13059-023-02931-y.","DOI":"10.1186\/s13059-023-02931-y"},{"key":"2026012711033092280_j_biol-2025-1242_ref_017","doi-asserted-by":"crossref","unstructured":"Munteanu, C, Turnea, MA, Rotariu, M. Hydrogen sulfide: an emerging regulator of oxidative stress and cellular Homeostasis-A comprehensive one-year review. Antioxidants (Basel) 2023;12:1737. https:\/\/doi.org\/10.3390\/antiox12091737.","DOI":"10.3390\/antiox12091737"},{"key":"2026012711033092280_j_biol-2025-1242_ref_018","doi-asserted-by":"crossref","unstructured":"Yan, W, He, X, Wang, G, Hu, G, Cui, B. Adipokine vaspin maintains angiogenesis and neurological function during cerebral ischemia-reperfusion via suppressing endoplasmic reticulum stress. Clin Hemorheol Microcirc 2024;87:415\u201325. https:\/\/doi.org\/10.3233\/CH-232077.","DOI":"10.3233\/CH-232077"},{"key":"2026012711033092280_j_biol-2025-1242_ref_019","doi-asserted-by":"crossref","unstructured":"Jin, T, Lu, H, Zhou, Q, Chen, D, Zeng, Y, Shi, J, et al.. H(2)S-Releasing versatile montmorillonite nanoformulation trilogically renovates the gut microenvironment for inflammatory bowel disease modulation. Adv Sci (Weinh) 2024;11:e2308092. https:\/\/doi.org\/10.1002\/advs.202308092.","DOI":"10.1002\/advs.202308092"},{"key":"2026012711033092280_j_biol-2025-1242_ref_020","doi-asserted-by":"crossref","unstructured":"Sigafoos, AN, Paradise, BD, Fernandez-zapico, ME. Hedgehog\/GLI signaling pathway: transduction, regulation, and implications for disease. Cancers (Basel) 2021;13:3410. https:\/\/doi.org\/10.3390\/cancers13143410.","DOI":"10.3390\/cancers13143410"},{"key":"2026012711033092280_j_biol-2025-1242_ref_021","doi-asserted-by":"crossref","unstructured":"Peer, E, Aichberger, SK, Vilotic, F, Gruber, W, Parigger, T, Grund-Gr\u00f6schke, S, et al.. Casein kinase 1D encodes a novel drug target in Hedgehog-GLI-Driven cancers and tumor-initiating cells resistant to SMO inhibition. Cancers (Basel) 2021;13:4227. https:\/\/doi.org\/10.3390\/cancers13164227.","DOI":"10.3390\/cancers13164227"},{"key":"2026012711033092280_j_biol-2025-1242_ref_022","doi-asserted-by":"crossref","unstructured":"Cai, L, Meng, B, Jiang, F, Shu, WH, Wang, XH, Wang, MQ, et al.. Novel HIF-1\u03b1 inhibitor AMSP-30m mitigates the pathogenic cellular behaviors of hypoxia-stimulated fibroblast-like synoviocytes and alleviates collagen-induced arthritis in rats via inhibiting sonic hedgehog pathway. Inflammation 2023;46:2289\u2013305. https:\/\/doi.org\/10.1007\/s10753-023-01878-3.","DOI":"10.1007\/s10753-023-01878-3"},{"key":"2026012711033092280_j_biol-2025-1242_ref_023","doi-asserted-by":"crossref","unstructured":"Liao, H, Huang, J, Liu, J, Zhu, H, Chen, Y, Li, X, et al.. Sirt1 regulates microglial activation and inflammation following oxygen-glucose deprivation\/reoxygenation injury by targeting the Shh\/Gli-1 signaling pathway. Mol Biol Rep 2023;50:3317\u201327. https:\/\/doi.org\/10.1007\/s11033-022-08167-6.","DOI":"10.1007\/s11033-022-08167-6"},{"key":"2026012711033092280_j_biol-2025-1242_ref_024","doi-asserted-by":"crossref","unstructured":"Yu, P, Wang, L, Tang, F, Guo, S, Liao, H, Fan, C, et al.. Resveratrol-mediated neurorestoration after cerebral ischemic injury\u00a0\u2013\u00a0sonic hedgehog signaling pathway. Life Sci 2021;280:119715. https:\/\/doi.org\/10.1016\/j.lfs.2021.119715.","DOI":"10.1016\/j.lfs.2021.119715"},{"key":"2026012711033092280_j_biol-2025-1242_ref_025","doi-asserted-by":"crossref","unstructured":"Li, Y, Xue, W, Li, S, Cui, L, Gao, Y, Li, L, et al.. Salidroside promotes angiogenesis after cerebral ischemia in mice through Shh signaling pathway. Biomed Pharmacother 2024;174:116625. https:\/\/doi.org\/10.1016\/j.biopha.2024.116625.","DOI":"10.1016\/j.biopha.2024.116625"},{"key":"2026012711033092280_j_biol-2025-1242_ref_026","doi-asserted-by":"crossref","unstructured":"Qi, QR, Lechuga, TJ, Patel, B, Nguyen, NA, Yang, YH, Li, Y, et al.. Enhanced stromal cell CBS-H2S production promotes estrogen-stimulated human endometrial angiogenesis. Endocrinology 2020;161:bqaa176. https:\/\/doi.org\/10.1210\/endocr\/bqaa176.","DOI":"10.1210\/endocr\/bqaa176"},{"key":"2026012711033092280_j_biol-2025-1242_ref_027","doi-asserted-by":"crossref","unstructured":"Wang, J, Zhan, H, Wang, M, Song, H, Sun, J, Zhao, G. Sonic hedgehog signaling promotes angiogenesis of endothelial progenitor cells to improve pressure ulcers healing by PI3K\/AKT\/eNOS signaling. Aging (Albany NY) 2023;15:10540\u20138. https:\/\/doi.org\/10.18632\/aging.205093.","DOI":"10.18632\/aging.205093"},{"key":"2026012711033092280_j_biol-2025-1242_ref_028","doi-asserted-by":"crossref","unstructured":"Shen, J, Li, Y, Li, M, Li, Z, Deng, H, Xie, X, et al.. Restoration of Cullin3 gene expression enhances the improved effects of sonic hedgehog signaling activation for hypertension and attenuates the dysfunction of vascular smooth muscle cells. Biomed Eng Online 2022;21:39. https:\/\/doi.org\/10.1186\/s12938-022-01002-w.","DOI":"10.1186\/s12938-022-01002-w"},{"key":"2026012711033092280_j_biol-2025-1242_ref_029","doi-asserted-by":"crossref","unstructured":"Hu, X, Xiao, Y, Sun, J, Ji, B, Luo, S, Wu, B, et al.. New possible silver lining for pancreatic cancer therapy: hydrogen sulfide and its donors. Acta Pharm Sin B 2021;11:1148\u201357. https:\/\/doi.org\/10.1016\/j.apsb.2020.10.019.","DOI":"10.1016\/j.apsb.2020.10.019"},{"key":"2026012711033092280_j_biol-2025-1242_ref_030","unstructured":"Yang, L, Yang, BC, Zhang, CX, Tong, J. Protective effects of acupuncture and LGNHFD on expressions of vascular endothelial growth factor, basic fibroblast growth factor, and cluster of differentiation 34 in rats with cerebral ischemia-reperfusion injury. J\u00a0Tradit Chin Med 2021;41:463\u201370. https:\/\/doi.org\/10.19852\/j.cnki.jtcm.2021.03.015."},{"key":"2026012711033092280_j_biol-2025-1242_ref_031","doi-asserted-by":"crossref","unstructured":"Cirino, G, Szabo, C, Papapetropoulos, A. Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs. Physiol Rev 2023;103:31\u2013276. https:\/\/doi.org\/10.1152\/physrev.00028.2021.","DOI":"10.1152\/physrev.00028.2021"},{"key":"2026012711033092280_j_biol-2025-1242_ref_032","doi-asserted-by":"crossref","unstructured":"Mannan, A, Dhiamn, S, Garg, N, Singh, TG. Pharmacological modulation of sonic hedgehog signaling pathways in angiogenesis: a mechanistic perspective. Dev Biol 2023;504:58\u201374. https:\/\/doi.org\/10.1016\/j.ydbio.2023.09.009.","DOI":"10.1016\/j.ydbio.2023.09.009"},{"key":"2026012711033092280_j_biol-2025-1242_ref_033","doi-asserted-by":"crossref","unstructured":"Lawal, O, Ulloa severino, FP, Eroglu, C. The role of astrocyte structural plasticity in regulating neural circuit function and behavior. Glia 2022;70:1467\u201383. https:\/\/doi.org\/10.1002\/glia.24191.","DOI":"10.1002\/glia.24191"},{"key":"2026012711033092280_j_biol-2025-1242_ref_034","doi-asserted-by":"crossref","unstructured":"Li, T, Chu, X, Xin, D, Ke, H, Wang, S, Liu, D, et al.. H(2)S prevents peripheral immune cell invasion, increasing [Ca(2+)]i and excessive phagocytosis following hypoxia-ischemia injury in neonatal mice. Biomed Pharmacother 2021;135:111207. https:\/\/doi.org\/10.1016\/j.biopha.2020.111207.","DOI":"10.1016\/j.biopha.2020.111207"},{"key":"2026012711033092280_j_biol-2025-1242_ref_035","doi-asserted-by":"crossref","unstructured":"Zhou, X, Chu, X, Xin, D, Li, T, Bai, X, Qiu, J, et al.. L-Cysteine-Derived H(2)S promotes microglia M2 polarization via activation of the AMPK pathway in hypoxia-ischemic neonatal mice. Front Mol Neurosci 2019;12:58. https:\/\/doi.org\/10.3389\/fnmol.2019.00058.","DOI":"10.3389\/fnmol.2019.00058"},{"key":"2026012711033092280_j_biol-2025-1242_ref_036","doi-asserted-by":"crossref","unstructured":"Zhu, YX, Yang, Q, Zhang, YP, Liu, ZG. FGF2 functions in H(2)S\u2019s attenuating effect on brain injury induced by deep hypothermic circulatory arrest in rats. Mol Biotechnol 2024;66:3526\u201337. https:\/\/doi.org\/10.1007\/s12033-02.","DOI":"10.1007\/s12033-023-00952-3"},{"key":"2026012711033092280_j_biol-2025-1242_ref_037","doi-asserted-by":"crossref","unstructured":"Niu, X, Li, M, Gao, Y, Xu, G, Dong, X, Chu, B, et al.. DL-3-n-butylphthalide suppressed autophagy and promoted angiogenesis in rats with vascular dementia by activating the Shh\/Ptch1 signaling pathway. Neurosci Lett 2021;20:765:136266. https:\/\/doi.org\/10.1016\/j.neulet.2021.136266.","DOI":"10.1016\/j.neulet.2021.136266"},{"key":"2026012711033092280_j_biol-2025-1242_ref_038","doi-asserted-by":"crossref","unstructured":"Deng, G, Muqadas, M, Adlat, S, Zheng, H, Li, G, Zhu, P, et al.. Protective effect of hydrogen sulfide on cerebral ischemia-reperfusion injury. Cell Mol Neurobiol 2023;43:15\u201325. https:\/\/doi.org\/10.1007\/s10571-021-01166-4.","DOI":"10.1007\/s10571-021-01166-4"},{"key":"2026012711033092280_j_biol-2025-1242_ref_039","doi-asserted-by":"crossref","unstructured":"Wu, J, Yang, F, Zhang, X, Chen, G, Zou, J, Yin, L, et al.. Hydrogen sulfide inhibits endoplasmic reticulum stress through the GRP78\/mTOR pathway in rat chondrocytes subjected to oxidative stress. Int J Mol Med 2021;47:34. https:\/\/doi.org\/10.3892\/ijmm.2021.4867.","DOI":"10.3892\/ijmm.2021.4867"},{"key":"2026012711033092280_j_biol-2025-1242_ref_040","doi-asserted-by":"crossref","unstructured":"Duan, SF, Zhang, MM, Zhang, X, Liu, W, Zhang, SH, Yang, B, et al.. HA-ADT suppresses esophageal squamous cell carcinoma progression via apoptosis promotion and autophagy inhibition. Exp Cell Res 2022;420:113341. https:\/\/doi.org\/10.1016\/j.yexcr.2022.113341.","DOI":"10.1016\/j.yexcr.2022.113341"},{"key":"2026012711033092280_j_biol-2025-1242_ref_041","doi-asserted-by":"crossref","unstructured":"El-Demerdash, AA, Darwish, SF, El-Derany, MO, El-Demerdash, E. Dapagliflozin targets the crosstalk between apoptosis, autophagy, and hedgehog signaling pathways through AMPK activation in the adjuvant-induced arthritic rat model. Inflammopharmacology 2025;33:3157\u201376. https:\/\/doi.org\/10.1007\/s10787-025-01750-w.","DOI":"10.1007\/s10787-025-01750-w"},{"key":"2026012711033092280_j_biol-2025-1242_ref_042","doi-asserted-by":"crossref","unstructured":"Yang, X, Jin, N, Wang, Y, Yao, Y, Wang, Y, Li, T, et al.. Macroautophagy supports sonic hedgehog signaling by promoting Patched1 degradation. Biochim Biophys Acta Mol Cell Res 2021;1868:119124. https:\/\/doi.org\/10.1016\/j.bbamcr.2021.119124.","DOI":"10.1016\/j.bbamcr.2021.119124"},{"key":"2026012711033092280_j_biol-2025-1242_ref_043","doi-asserted-by":"crossref","unstructured":"Jiang, L, Yang, S, Deng, L, Luo, J, Zhang, X, Chen, S, et al.. ARL13B promotes cell cycle through the sonic hedgehog signaling pathway to alleviate nerve damage during cerebral ischemia\/reperfusion in rats. Biochem Pharmacol 2024;227:116446. https:\/\/doi.org\/10.1016\/j.bcp.2024.116446.","DOI":"10.1016\/j.bcp.2024.116446"},{"key":"2026012711033092280_j_biol-2025-1242_ref_044","doi-asserted-by":"crossref","unstructured":"Viswakarma, N, Sondarva, G, Principe, DR, Nair, RS, Kumar, S, Singh, SK, et al.. Mixed lineage kinase 3 phosphorylates prolyl-isomerase PIN1 and potentiates GLI1 signaling in pancreatic cancer development. Cancer Lett 2021;515:1\u201313. https:\/\/doi.org\/10.1016\/j.canlet.2021.04.015.","DOI":"10.1016\/j.canlet.2021.04.015"},{"key":"2026012711033092280_j_biol-2025-1242_ref_045","doi-asserted-by":"crossref","unstructured":"Wang, B, Xu, T, Qiu, C, Yu, L, Xu, S, Zhao, X, et al.. Tenovin-6 exhibits inhibitory effects on the growth of sonic hedgehog (SHH) medulloblastoma, as evidenced by both in\u00a0vitro and in\u00a0vivo studies. Int Immunopharmacol 2024;142:113075. https:\/\/doi.org\/10.1016\/j.intimp.2024.113075.","DOI":"10.1016\/j.intimp.2024.113075"},{"key":"2026012711033092280_j_biol-2025-1242_ref_046","doi-asserted-by":"crossref","unstructured":"Wen, J, Tang, H, Tian, M, Wang, L, Yang, Q, Zhao, Y, et al.. Fibrotic scar formation after cerebral ischemic stroke: targeting the sonic hedgehog signaling pathway for scar reduction. Neural Regen Res 2026;21:756\u201368. https:\/\/doi.org\/10.4103\/NRR.NRR-D-24-00999.","DOI":"10.4103\/NRR.NRR-D-24-00999"},{"key":"2026012711033092280_j_biol-2025-1242_ref_047","doi-asserted-by":"crossref","unstructured":"Wu, D, Tan, B, Sun, Y, Hu, Q. Cystathionine \u03b3 lyase S-sulfhydrates Drp1 to ameliorate heart dysfunction. Redox Biol 2022;58:102519. https:\/\/doi.org\/10.1016\/j.redox.2022.102519.","DOI":"10.1016\/j.redox.2022.102519"},{"key":"2026012711033092280_j_biol-2025-1242_ref_048","doi-asserted-by":"crossref","unstructured":"Prajapati, A, Mehan, S, Khan, Z. The role of Smo-Shh\/Gli signaling activation in the prevention of neurological and ageing disorders. Biogerontology 2023;24:493\u2013531. https:\/\/doi.org\/10.1007\/s10522-023-10034-1.","DOI":"10.1007\/s10522-023-10034-1"}],"container-title":["Open Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/biol-2025-1242\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/biol-2025-1242\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T11:03:49Z","timestamp":1769511829000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/biol-2025-1242\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,1]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,28]]},"published-print":{"date-parts":[[2026,1,23]]}},"alternative-id":["10.1515\/biol-2025-1242"],"URL":"https:\/\/doi.org\/10.1515\/biol-2025-1242","relation":{},"ISSN":["2391-5412"],"issn-type":[{"value":"2391-5412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,1]]},"article-number":"20251242"}}