{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T03:37:43Z","timestamp":1777174663643,"version":"3.51.4"},"reference-count":34,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Retinal ganglion cell (RGC) loss involves p53 activation and calcium overload. The role of RNA-binding proteins like ELAVL1 in this process remains unclear. We investigated whether ELAVL1 protects retinal cells by post-transcriptionally regulating WD Repeat Domain 36 (WDR36).\n                    <jats:italic>In vitro<\/jats:italic>\n                    stress was modeled using oxygen-glucose deprivation\/reperfusion (OGD\/R) in R28 retinal precursor cells.\n                    <jats:italic>In vivo<\/jats:italic>\n                    acute intraocular pressure (IOP) elevation was induced in mice. We modulated gene expression with siRNA, plasmids, or AAV vectors, assessing cell death, calcium levels, and protein markers. OGD\/R downregulated ELAVL1 and WDR36 protein, but not WDR36 mRNA. ELAVL1 bound WDR36 mRNA and promoted its protein translation. Overexpression of either ELAVL1 or WDR36 reduced OGD\/R-induced cell death, calcium overload, and p53 pathway activation. Crucially, WDR36 knockdown abolished ELAVL1\u2019s protective effects\n                    <jats:italic>in\u00a0vitro<\/jats:italic>\n                    .\n                    <jats:italic>In vivo<\/jats:italic>\n                    , AAV-mediated ELAVL1 overexpression mitigated IOP-induced retinal damage and apoptosis, which was reversed by co-knockdown of WDR36. The ELAVL1-WDR36 axis is a critical post-transcriptional mechanism that promotes retinal cell survival under acute pressure-ischemia stress by inhibiting p53 activation and calcium overload, highlighting its therapeutic potential.\n                  <\/jats:p>","DOI":"10.1515\/biol-2025-1279","type":"journal-article","created":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T03:10:32Z","timestamp":1777173032000},"source":"Crossref","is-referenced-by-count":0,"title":["RNA-binding protein ELAVL1 modulates WDR36 to inhibit p53 pathway and reduce calcium overload in retinal cells under acute pressure elevation"],"prefix":"10.1515","volume":"21","author":[{"given":"QingFeng","family":"Meng","sequence":"first","affiliation":[{"name":"Health Center of Screening and Prevention of Diseases , First Affiliated Hospital of Harbin Medical University , Harbin City , Heilongjiang Province , 150001 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"BaoLi","family":"Ning","sequence":"additional","affiliation":[{"name":"Health Center of Screening and Prevention of Diseases , First Affiliated Hospital of Harbin Medical University , Harbin City , Heilongjiang Province , 150001 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WenXiong","family":"Chen","sequence":"additional","affiliation":[{"name":"Health Center of Screening and Prevention of Diseases , First Affiliated Hospital of Harbin Medical University , Harbin City , Heilongjiang Province , 150001 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JingJing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Health Center of Screening and Prevention of Diseases , First Affiliated Hospital of Harbin Medical University , Harbin City , Heilongjiang Province , 150001 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3976-6408","authenticated-orcid":false,"given":"Jun","family":"Fu","sequence":"additional","affiliation":[{"name":"Health Center of Screening and Prevention of Diseases , First Affiliated Hospital of Harbin Medical University , Harbin City , Heilongjiang Province , 150001 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2026,4,20]]},"reference":[{"key":"2026042603102946634_j_biol-2025-1279_ref_001","doi-asserted-by":"crossref","unstructured":"Angeloni, C, Gatti, M, Prata, C, Hrelia, S, Maraldi, T. 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