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Forty-two Sprague Dawley rats were randomly assigned to six groups: control, morin (200\u202fmg\/kg\/day), propolis (100\u202fmg\/kg\/day), Cyt (100\u202fmg\/kg\/day), morin\u00a0+\u00a0Cyt, and propolis\u00a0+\u00a0Cyt. Biochemical analysis of brain tissue revealed that Cyt administration significantly elevated malondialdehyde (MDA) levels and glutathione-S-transferase (GST) activity, while depleting catalase (CAT) and glutathione peroxidase (GSH-Px) activities. Immunohistochemical findings showed that Cyt increased 8-hydroxydeoxyguanosine (8-OHdG) and B-cell lymphoma\/leukemia-2-associated X protein (Bax) expression, whereas it downregulated Glutathione peroxidase 4 (GPX4) and B-cell lymphoma\/leukemia-2 (Bcl-2). Treatment with morin or propolis effectively reversed these oxidative and apoptotic markers, as evidenced by\u00a0decreased MDA and Bax levels, alongside increased activities of antioxidant enzymes. Furthermore, the histopathological alterations induced by Cyt were markedly ameliorated by both antioxidants. These results suggest that Cyt-induced neuronal degeneration is driven by oxidative stress and apoptosis, processes that can be mitigated by morin and propolis supplementation.<\/jats:p>","DOI":"10.1515\/biol-2025-1289","type":"journal-article","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T13:56:15Z","timestamp":1771509375000},"source":"Crossref","is-referenced-by-count":0,"title":["Protective effects of morin and propolis against cytarabine-induced neurotoxicity: a multi-biomarker approach"],"prefix":"10.1515","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1846-3842","authenticated-orcid":false,"given":"Hakan","family":"Ba\u011f","sequence":"first","affiliation":[{"name":"Biochemistry Department , Firat University Veterinary Faculty , 23200 , Elazig , T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2040-9247","authenticated-orcid":false,"given":"Seval","family":"Y\u0131lmaz","sequence":"additional","affiliation":[{"name":"Biochemistry Department , Firat University Veterinary Faculty , 23200 , Elazig , T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2331-6203","authenticated-orcid":false,"given":"Song\u00fcl","family":"\u00c7eriba\u015f\u0131","sequence":"additional","affiliation":[{"name":"Pathology Department , Firat University Veterinary Faculty , 23200 , Elazig , T\u00fcrkiye"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2026,2,20]]},"reference":[{"key":"2026021913560921015_j_biol-2025-1289_ref_001","doi-asserted-by":"crossref","unstructured":"Majed, MS, Hassan, MS, Mousa, RF, Hassan, MS, Mohammed, OA, AL-Nuaimi, AJ, et al.. 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