{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T18:10:51Z","timestamp":1772734251648,"version":"3.50.1"},"reference-count":38,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>We investigated whether vitamin D (VD) alleviates type 2 diabetes mellitus (T2DM) by modulating autophagy and inflammation. In wild-type diabetic mice, VD supplementation significantly improved glucose tolerance, reduced fasting blood glucose, and the HOMA-IR (homeostasis model assessment of insulin resistance) index (P\u00a0&lt;\u00a00.05). Serum levels of IL-1\u03b2, TNF-\u03b1, and tissue reactive oxygen species were markedly elevated in T2DM mice but significantly decreased after VD treatment (P\u00a0&lt;\u00a00.05). Histopathological and ultrastructural analyses revealed that VD preserved pancreatic and kidney tissue integrity and increased autophagic structures. Consistently, VD upregulated Beclin-1 and LC3-II while downregulating IL-1\u03b2 and NF-\u03baB p65 expression in these tissues (P\u00a0&lt;\u00a00.05). In contrast, these beneficial effects of VD were largely absent in NLRP3-knockout T2DM mice. Collectively, vitamin D exerts therapeutic effects in T2DM by promoting autophagy and inhibiting inflammation, primarily through the ROS-NLRP3-IL-1\u03b2-NF-\u03baB signaling pathway.<\/jats:p>","DOI":"10.1515\/biol-2025-1294","type":"journal-article","created":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T17:10:57Z","timestamp":1772730657000},"source":"Crossref","is-referenced-by-count":0,"title":["Vitamin D alleviates type 2 diabetes by promoting autophagy and inhibiting inflammation via the NLRP3 inflammasome pathway"],"prefix":"10.1515","volume":"21","author":[{"given":"Qian","family":"Ren","sequence":"first","affiliation":[{"name":"Laboratory Animal Center of Suzhou Medical College, Soochow University , Suzhou 215123 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Suzhou Kezhuo Medical Technology Co., Ltd , Suzhou 215000 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengpei","family":"Ni","sequence":"additional","affiliation":[{"name":"Wuxi Center for Disease Control and Prevention , Wuxi 214023 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lewen","family":"Zhang","sequence":"additional","affiliation":[{"name":"CCIC Huatongwei International Inspection Co., Ltd , Suzhou 215123 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yudie","family":"Hu","sequence":"additional","affiliation":[{"name":"Second Affiliated Hospital of Soochow University , Suzhou 215004 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Xiao","sequence":"additional","affiliation":[{"name":"Laboratory Animal Center of Suzhou Medical College, Soochow University , Suzhou 215123 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5712-9495","authenticated-orcid":false,"given":"Zhengyu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Laboratory Animal Center of Suzhou Medical College, Soochow University , Suzhou 215123 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2026,3,5]]},"reference":[{"key":"2026030517123243250_j_biol-2025-1294_ref_001","doi-asserted-by":"crossref","unstructured":"Tan, SY, Mei Wong, JL, Sim, YJ, Wong, SS, Mohamed Elhassan, SA, Tan, SH, et al.. 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