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MNP\/G nanomaterials were synthesized via covalent co-precipitation and introduced into HFSF cultures. Cells were co-cultured with 30\u202f\u03bcg\/mL MNP\/G and exposed to static magnetic stimulation (20\u202fmT intensity). Proliferation was assessed via CCK-8 assay, morphology was observed using inverted phase-contrast microscopy, and hydroxyproline content was measured to quantify collagen synthesis. Magnetic stimulation significantly enhanced HFSF proliferation compared to non-stimulated controls, with no\u00a0observed cytotoxicity. Microscopic analysis revealed improved cell density and spindle-like morphology in stimulated groups. Hydroxyproline assays demonstrated a marked increase in collagen synthesis following magnetic stimulation, suggesting enhanced extracellular matrix production. Notably, the combined application of MNP\/G nanomaterials and magnetic stimulation yielded the highest collagen content among all experimental conditions. Magnetic stimulation using MNP\/G nanomaterials promotes HFSF proliferation and collagen production, potentially strengthening scleral biomechanical properties. This approach may counteract scleral remodeling in myopia progression, offering a novel strategy for non-invasive myopia intervention.<\/jats:p>","DOI":"10.1515\/biol-2025-1316","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T16:38:46Z","timestamp":1777653526000},"source":"Crossref","is-referenced-by-count":0,"title":["Functionalized chitosan\u2013graphene magnetic nanocomposites enhance collagen synthesis in scleral fibroblasts"],"prefix":"10.1515","volume":"21","author":[{"given":"Xiaojie","family":"Huang","sequence":"first","affiliation":[{"name":"Zhejiang Industry and Trade Vocational College , Wenzhou , Zhejiang , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7094-5729","authenticated-orcid":false,"given":"Zijian","family":"Wang","sequence":"additional","affiliation":[{"name":"Wenzhou Medical University , Wenzhou , Zhejiang , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[{"name":"Zhejiang Industry and Trade Vocational College , Wenzhou , Zhejiang , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3005-2875","authenticated-orcid":false,"given":"Yingying","family":"Dai","sequence":"additional","affiliation":[{"name":"Zhejiang Industry and Trade Vocational College , Wenzhou , Zhejiang , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9772-7581","authenticated-orcid":false,"given":"Ruikang","family":"Tian","sequence":"additional","affiliation":[{"name":"Zhejiang Industry and Trade Vocational College , Wenzhou , Zhejiang , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2026,4,30]]},"reference":[{"key":"2026050119573819966_j_biol-2025-1316_ref_001","doi-asserted-by":"crossref","unstructured":"Ku, PW, Steptoe, A, Lai, YJ, Hu, HY, Chu, D, Yen, YF, et al.. 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