{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T12:01:45Z","timestamp":1780660905646,"version":"3.54.1"},"reference-count":43,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzhen","doi-asserted-by":"crossref","award":["SZSM202411006"],"award-info":[{"award-number":["SZSM202411006"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus and represents a major risk factor for mortality. The critical pathological process affecting the renal parenchyma is fibrosis, which ultimately progresses to end-stage kidney disease. Identifying the molecular mediators of fibrosis is crucial for developing novel therapeutic strategies for lupus patients. Herein, we demonstrate that alpha-1-antichymotrypsin (AACT) is a critical inducer of the epithelial-mesenchymal transition (EMT) in HK-2 cells. Immunohistochemical analysis reveal that AACT expression progressively increases with advancing LN class. We next generate AACT knockout (AACT\n                    <jats:sup>KO<\/jats:sup>\n                    ) and overexpressing (AACT\n                    <jats:sup>OE<\/jats:sup>\n                    ) HK-2 cell lines. Our results indicate that AACT levels are positively correlated with cellular migration, the expression of migration-associated proteases, and collagen secretion in HK-2 cells. Notably, AACT inhibits the expression of the epithelial marker E-cadherin while promoting that of the mesenchymal marker \u03b1-SMA. Therefore, these findings suggest that AACT may contribute to renal fibrosis via triggering EMT, thereby promoting cell migration and collagen accumulation within renal tissues. Our study identifies AACT as a potential therapeutic target to counteract LN-associated renal fibrosis.\n                  <\/jats:p>","DOI":"10.1515\/biol-2025-1319","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T12:17:25Z","timestamp":1779797845000},"source":"Crossref","is-referenced-by-count":0,"title":["Alpha-1-antichymotrypsin: a potential inducer for epithelial-mesenchymal transition in lupus nephritis"],"prefix":"10.1515","volume":"21","author":[{"given":"Xiaoyan","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Nephrology , Peking University Shenzhen Hospital , Shenzhen , Guangdong Province , 518036 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuijuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery , First Center of 301 Chinese PLA General Hospital , Beijing , 100853 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology , Shenzhen People\u2019s Hospital , Shenzhen 518020 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6712-9357","authenticated-orcid":false,"given":"Xiaoshu","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology , Shenzhen Second People\u2019s Hospital, The First Affiliated Hospital of Shenzhen University , Shenzhen , Guangdong Province , 518055 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine , Shenzhen Second People\u2019s Hospital, The First Affiliated Hospital of Shenzhen University , Shenzhen , Guangdong Province , 518020 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingjiao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology , Shenzhen Second People\u2019s Hospital, The First Affiliated Hospital of Shenzhen University , Shenzhen , Guangdong Province , 518055 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology , Shenzhen Second People\u2019s Hospital, The First Affiliated Hospital of Shenzhen University , Shenzhen , Guangdong Province , 518055 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1260-6291","authenticated-orcid":false,"given":"Yongfei","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Medicine and Warshel Institute for Computational Biology, Chinese University of Hong Kong , Shenzhen , Guangdong , China"},{"name":"Department of Paediatrics and Adolescent Medicine , University of Hong Kong , Hong Kong , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5660-1609","authenticated-orcid":false,"given":"Yushuang","family":"Wei","sequence":"additional","affiliation":[{"name":"Songshan Lake Materials Laboratory , Dongguan , Guangdong Province , 523808 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8418-9274","authenticated-orcid":false,"given":"Bing","family":"Yuan","sequence":"additional","affiliation":[{"name":"Songshan Lake Materials Laboratory , Dongguan , Guangdong Province , 523808 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology , Shenzhen Second People\u2019s Hospital, The First Affiliated Hospital of Shenzhen University , Shenzhen , Guangdong Province , 518055 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,5,20]]},"reference":[{"key":"2026060511075288887_j_biol-2025-1319_ref_001","doi-asserted-by":"crossref","unstructured":"Barber, M, Drenkard, C, Falasinnu, T, Hoi, A, Mak, A, Kow, N, et al.. 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Systemic lupus erythematosus-diagnosis and classification of the disease in the past and in present times. Srp Ark Celok Lek 2024;152:97\u2013102. https:\/\/doi.org\/10.2298\/sarh231001008z.","DOI":"10.2298\/SARH231001008Z"},{"key":"2026060511075288887_j_biol-2025-1319_ref_005","doi-asserted-by":"crossref","unstructured":"Anders, H, Saxena, R, Zhao, M, Parodis, I, Salmon, J, Mohan, C. Lupus nephritis. Nat Rev Dis Primers 2020;6:7. https:\/\/doi.org\/10.1038\/s41572-019-0141-9.","DOI":"10.1038\/s41572-019-0141-9"},{"key":"2026060511075288887_j_biol-2025-1319_ref_006","doi-asserted-by":"crossref","unstructured":"Mok, C, Teng, Y, Saxena, R, Tanaka, Y. Treatment of lupus nephritis: consensus, evidence and perspectives. Nat Rev Rheumatol 2023;19:227\u201338. https:\/\/doi.org\/10.1038\/s41584-023-00925-5.","DOI":"10.1038\/s41584-023-00925-5"},{"key":"2026060511075288887_j_biol-2025-1319_ref_007","doi-asserted-by":"crossref","unstructured":"Yu, C, Li, P, Dang, X, Zhang, X, Mao, Y, Chen, X. Lupus nephritis: new progress in diagnosis and treatment. J\u00a0Autoimmun 2022;132:102871. https:\/\/doi.org\/10.1016\/j.jaut.2022.102871.","DOI":"10.1016\/j.jaut.2022.102871"},{"key":"2026060511075288887_j_biol-2025-1319_ref_008","doi-asserted-by":"crossref","unstructured":"Tamirou, F, Houssiau, F. Management of lupus nephritis. J\u00a0Clin Med 2021;10:670. https:\/\/doi.org\/10.3390\/jcm10040670.","DOI":"10.3390\/jcm10040670"},{"key":"2026060511075288887_j_biol-2025-1319_ref_009","doi-asserted-by":"crossref","unstructured":"Sun, Y, Huang, D, Chang, F, Chen, W, Liao, H, Chen, M, et al.. Interstitial fibrosis increases the risk of end-stage kidney disease in patients with lupus nephritis. Rheumatology 2024;63:2467\u201372. https:\/\/doi.org\/10.1093\/rheumatology\/keae226.","DOI":"10.1093\/rheumatology\/keae226"},{"key":"2026060511075288887_j_biol-2025-1319_ref_010","doi-asserted-by":"crossref","unstructured":"Mejia-Vilet, J, Malvar, A, Arazi, A, Rovin, B. 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Curr Diabetes Rev 2021;17:1\u201312. https:\/\/doi.org\/10.2174\/1573399816999201012200537.","DOI":"10.2174\/1573399816999201012200537"},{"key":"2026060511075288887_j_biol-2025-1319_ref_020","doi-asserted-by":"crossref","unstructured":"Mahadeva, R, Sharples, L, Ross-Russell, R, Webb, A, Bilton, D, Lomas, D.\u00a0Association of \u03b11-antichymotrypsin deficiency with milder\u00a0lung\u00a0disease in patients with cystic fibrosis. Thorax 2001;56:53\u20138. https:\/\/doi.org\/10.1136\/thorax.56.1.53.","DOI":"10.1136\/thorax.56.1.53"},{"key":"2026060511075288887_j_biol-2025-1319_ref_021","doi-asserted-by":"crossref","unstructured":"Turnier, J, Brunner, H, Bennett, M, Aleed, A, Gulati, G, Haffey, W, et al.. Discovery of SERPINA3 as a candidate urinary biomarker of lupus nephritis activity. 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