{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T18:00:48Z","timestamp":1780596048339,"version":"3.54.1"},"reference-count":19,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"2025 Xingtai Key Research and Development Program Project: \u201cClinical Research and Application of Artificial Intelligence-Based Auxiliary Diagnosis for Skin Diseases\u201d, S&T Program of Xingtai","award":["2025ZC701"],"award-info":[{"award-number":["2025ZC701"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A typical case of eruptive xanthomas secondary to untreated type 2 diabetes mellitus complicated with severe hyperlipidemia was reported. The patient had a history of acute pancreatitis one month before the onset of xanthomas. Laboratory tests revealed high levels of triglycerides, cholesterol, blood glucose, and acute inflammatory markers. Histopathological examination showed the foam cells in the dermis. After interventions, including a low-fat and low-carbohydrate diet, anti-diabetic therapy and lipid-lowering therapy, the patient\u2019s skin lesions partially resolved within two months. At the same time, all laboratory indicators improved. In addition, a comprehensive literature review was conducted on the pathophysiological mechanisms, key clinical diagnostic points, triglyceride level thresholds, and\u00a0main treatment strategies of eruptive xanthomas. This study emphasizes that eruptive xanthomas and acute pancreatitis are clinical manifestations induced by severe hypertriglyceridemia. For dermatologists, the occurrence of eruptive xanthomas should be used as a trigger to screen for dyslipidemia to effectively prevent life-threatening severe complications.<\/jats:p>","DOI":"10.1515\/biol-2025-1327","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T16:59:53Z","timestamp":1780592393000},"source":"Crossref","is-referenced-by-count":0,"title":["Eruptive xanthomas: a case report with literature review focusing on pathogenesis and clinical management"],"prefix":"10.1515","volume":"21","author":[{"given":"Xianhua","family":"Qiao","sequence":"first","affiliation":[{"name":"Xingtai People\u2019s Hospital , Xingtai , Hebei , 054035 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinglong","family":"Yu","sequence":"additional","affiliation":[{"name":"Hebei Vocational University of Technology and Engineering , Xingtai , Hebei , 054000 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanjuan","family":"Gao","sequence":"additional","affiliation":[{"name":"Xingtai People\u2019s Hospital , Xingtai , Hebei , 054035 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linfang","family":"Yang","sequence":"additional","affiliation":[{"name":"Xingtai People\u2019s Hospital , Xingtai , Hebei , 054035 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Xingtai People\u2019s Hospital , Xingtai , Hebei , 054035 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,5,25]]},"reference":[{"key":"2026060416594856009_j_biol-2025-1327_ref_001","doi-asserted-by":"crossref","unstructured":"Wollina, U, Koch, A, Hansel, G, Sch\u00f6nlebe, J. Eruptive Xanthomas\u00a0\u2013\u00a0two case reports with distinct features. Open Access Maced J Med Sci 2018;6:2152\u20134. https:\/\/doi.org\/10.3889\/oamjms.2018.458.","DOI":"10.3889\/oamjms.2018.458"},{"key":"2026060416594856009_j_biol-2025-1327_ref_002","doi-asserted-by":"crossref","unstructured":"Morka, J, Morajko, A, Otulak, S, Zara\u0144ska, K, W\u0105sik, G. Cutaneous manifestation of eruptive Xanthoma as a consequence of severe hypertriglyceridemia: a case report highlighting diagnostic and therapeutic challenges. Cureus 2025;17:e78329. https:\/\/doi.org\/10.7759\/cureus.78329.","DOI":"10.7759\/cureus.78329"},{"key":"2026060416594856009_j_biol-2025-1327_ref_003","doi-asserted-by":"crossref","unstructured":"Zak, A, Zeman, M, Slaby, A, Vecka, M. Xanthomas: clinical and pathophysiological relations. Biomed Pap Med Fac Palacky Univ Olomouc 2014;158:181\u20138. https:\/\/doi.org\/10.5507\/bp.2014.016.","DOI":"10.5507\/bp.2014.016"},{"key":"2026060416594856009_j_biol-2025-1327_ref_004","doi-asserted-by":"crossref","unstructured":"Anaba, EL, Cole-Adeife, OM, Oaku, RI. Case series: eruptive xanthomas and hyperlipdaemia. Int J Res Med Sci 2021;9:584. https:\/\/doi.org\/10.18203\/2320-6012.IJRMS20210447.","DOI":"10.18203\/2320-6012.ijrms20210447"},{"key":"2026060416594856009_j_biol-2025-1327_ref_005","doi-asserted-by":"crossref","unstructured":"Munoz, NR, Agwuegbo, CC, Gauhar, F. Eruptive xanthomas precipitated by severe hypertriglyceridemia from diabetes and alcohol use. Cureus 2023;15:e43288. https:\/\/doi.org\/10.7759\/cureus.43288.","DOI":"10.7759\/cureus.43288"},{"key":"2026060416594856009_j_biol-2025-1327_ref_006","doi-asserted-by":"crossref","unstructured":"Darawish, BE, Broshtilova, V, Yungareva, I, Smilov, N, Trenovski, A, Velevska, Y, et al.. 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