{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T08:17:33Z","timestamp":1788164253422,"version":"build-2803163510"},"reference-count":45,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Allergic rhinitis (AR) is a common chronic inflammatory disorder characterized by nasal mucosal inflammation, sneezing, and rhinorrhea. Schisandrin A (Schis-A) has demonstrated significant anti-inflammatory effects in models of allergic asthma. This study aimed to evaluate the therapeutic efficacy of Schis-A in AR and to elucidate its underlying molecular mechanisms. An AR mouse model was established by sensitization and challenge with ovalbumin (OVA), followed by oral administration of Schis-A at doses of 40 and 80\u202fmg\/kg\/day. Nasal symptoms were monitored and quantified. OVA-specific immunoglobulin E (IgE) levels and T helper (Th)1\/Th2- and regulatory T\u00a0cells (Treg)\/Th17-associated cytokines were measured using enzyme-linked immunosorbent assay and quantitative real-time PCR. Treg and Th17 cell populations were analyzed by flow cytometry. The results showed that Schis-A treatment significantly reduced OVA-induced nasal rubbing and sneezing, indicating effective attenuation of allergic responses. Serum OVA-specific IgE levels were markedly reduced in Schis-A-treated AR mice. Moreover, Schis-A restored Th1\/Th2 and Treg\/Th17 cytokine balance, as indicated by upregulated expression of IFN-\u03b3, IL-2, and Foxp3, alongside downregulation of IL-4, IL-5, IL-13, and IL-17. Flow cytometric analysis confirmed an increase in Treg cells and a reduction in Th17 cell populations. Mechanistically, Schis-A inhibited activation of the PI3K\/AKT signaling pathway, suggesting that this pathway may contribute to its immunomodulatory effects. Schis-A alleviates AR by modulating Th1\/Th2 and Treg\/Th17 immune responses and inhibiting PI3K\/AKT pathway activation, offering a promising therapeutic strategy for the treatment of\u00a0AR.<\/jats:p>","DOI":"10.1515\/biol-2025-1348","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T07:56:35Z","timestamp":1788162995000},"source":"Crossref","is-referenced-by-count":0,"title":["Schisandrin A alleviates allergic rhinitis by restoring Th1\/Th2 and Treg\/Th17 immune balance"],"prefix":"10.1515","volume":"21","author":[{"given":"Zhipeng","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology , Shanghai Pudong New Area Hospital of Traditional Chinese Medicine , Shanghai , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"He","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology , Shanghai Children\u2019s Medical Center, Shanghai Jiao Tong University School of Medicine , Shanghai , 200120 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmin","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology , Shanghai Pudong New Area Hospital of Traditional Chinese Medicine , Shanghai , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjun","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology , Shanghai Pudong New Area Guangming Hospital of Traditional Chinese Medicine , Shanghai , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology , Shanghai Pudong New Area Hospital of Traditional Chinese Medicine , Shanghai , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyi","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology , Shanghai Pudong New Area Hospital of Traditional Chinese Medicine , Shanghai , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyi","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology , Shanghai Pudong New Area Hospital of Traditional Chinese Medicine , Shanghai , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology , Shanghai Pudong New Area Hospital of Traditional Chinese Medicine , Shanghai , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology , Shanghai Pudong New Area Hospital of Traditional Chinese Medicine , Shanghai , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Jiao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology , Shanghai Children\u2019s Medical Center, Shanghai Jiao Tong University School of Medicine , Shanghai , 200120 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"key":"2026083107562534072_j_biol-2025-1348_ref_001","doi-asserted-by":"crossref","unstructured":"Vieira, RJ, Sousa-Pinto, B, Bousquet, J, Schunemann, HJ, Zuberbier, T, Bognanni, A, et al.. 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