{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T14:25:36Z","timestamp":1788531936485,"version":"build-2803163510"},"reference-count":20,"publisher":"Walter de Gruyter GmbH","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study investigated transrectal ultrasound parameters and total serum exosome levels in prostate cancer (PCa) patients with bone metastasis (BM), and evaluated their combined value in assessing metastatic status. 40 PCa patients were categorized into non-bone metastasis (NBM, 21 cases) and BM (19 cases) groups based on single photon emission computed tomography\/computed tomography or bone scans. Serum exosomes were extracted and analyzed via nanoparticle tracking analysis, while transrectal ultrasound and ultrasound-guided biopsies were performed. The study compared exosome levels and ultrasound parameters between groups, and assessed their diagnostic value for BM using receiver operating characteristic (ROC) curves, and analyzed correlations between exosomes and ultrasound findings. PCa patients with BM showed significantly higher serum exosome concentrations and ultrasound parameters (peak intensity, area under the curve (AUC), and Grad) than NBM patients (p\u00a0&lt;\u00a00.001). ROC analysis revealed optimal cutoff values for discriminating BM: 19.33\u202fdB for PI, 1,156.63\u202fdB s for AUC, 2.02\u202fdB\/s for Grad, and 3.34\u00a0\u00d7\u00a0E\n                    <jats:sup>10<\/jats:sup>\n                    particles\/mL for exosomes. The combined test (AUC\u00a0=\u00a00.97) outperformed individual parameters (AUCs 0.83\u20130.89), demonstrating superior diagnostic performance in identifying PCa BM. In conclusion, this exploratory preliminary study indicates that exosomes may have potential application value in the assessment of PCa\u00a0BM.\n                  <\/jats:p>","DOI":"10.1515\/biol-2025-1358","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T13:56:26Z","timestamp":1788530186000},"source":"Crossref","is-referenced-by-count":0,"title":["Transrectal ultrasonographic parameters combined with total serum exosomes for the assessment of bone metastases in prostate cancer"],"prefix":"10.1515","volume":"21","author":[{"given":"Lingxu","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Functional Examination , University Hospital of Inner Mongolia for Nationalities , Tongliao 02800 , Inner Mongolia , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Ultrasound , Inner Mongolia People\u2019s Hospital , Hohhot 010017 , Inner Mongolia , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohua","family":"Wu","sequence":"additional","affiliation":[{"name":"Inner Mongolia Medical University , Hohhot 010107 , Inner Mongolia , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound , Inner Mongolia People\u2019s Hospital , Hohhot 010017 , Inner Mongolia , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,9,4]]},"reference":[{"key":"2026090413562270203_j_biol-2025-1358_ref_001","doi-asserted-by":"crossref","unstructured":"Ying, M, Mao, J, Sheng, L, Wu, H, Bai, G, Zhong, Z, et al.. 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