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This meta\u00a0\u2013\u00a0analysis evaluated biomarker differences between PI and healthy conditions in Asian adults, focusing on inflammatory cytokines (IL\u00a0\u2013\u00a01\u03b2, IL\u00a0\u2013\u00a06, TNF\u00a0\u2013\u00a0\u03b1) and SIRT1 in peri\u00a0\u2013\u00a0implant gingival crevicular fluid and saliva. Five databases were searched until August 2025. Random\u00a0\u2013\u00a0effects models were used for pooled analyses, and relevant indicators were calculated. Thirteen studies were included. IL\u00a0\u2013\u00a01\u03b2, IL\u00a0\u2013\u00a06, and TNF\u00a0\u2013\u00a0\u03b1 were significantly higher in PI with low heterogeneity and stable findings. SIRT1 showed potentially favorable discriminatory performance but with limited evidence. Biomarker type affected effect\u00a0\u2013\u00a0size variation, and mild small\u00a0\u2013\u00a0study asymmetry for IL\u00a0\u2013\u00a06 did not change overall conclusions. Overall, IL\u00a0\u2013\u00a01\u03b2, IL\u00a0\u2013\u00a06, and TNF\u00a0\u2013\u00a0\u03b1 can be candidate adjunctive biomarkers for PI assessment in Asian populations. SIRT1 is promising, but its diagnostic relevance conclusions are preliminary and need validation. Current evidence is limited. Further prospective studies in diverse populations and validation of clinically applicable thresholds and cost\u00a0\u2013\u00a0effectiveness are needed before broader clinical translation.<\/jats:p>","DOI":"10.1515\/biol-2025-1360","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:56:57Z","timestamp":1792169817000},"source":"Crossref","is-referenced-by-count":0,"title":["Oral-fluid inflammatory and oxidative-stress biomarkers for peri-implantitis in Asian adults: a systematic review and stratified random-effects meta-analysis"],"prefix":"10.1515","volume":"21","author":[{"given":"Lina","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Stomatology , The Third Medical Centre of PLA General Hospital , No. 69, Yongding Road, Haidian District, Beijing 100039 , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Stomatology , The Third Medical Centre of PLA General Hospital , No. 69, Yongding Road, Haidian District, Beijing 100039 , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenfeng","family":"He","sequence":"additional","affiliation":[{"name":"Department of Stomatology , The Third Medical Centre of PLA General Hospital , No. 69, Yongding Road, Haidian District, Beijing 100039 , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Stomatology , The Third Medical Centre of PLA General Hospital , No. 69, Yongding Road, Haidian District, Beijing 100039 , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxia","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Stomatology , The Third Medical Centre of PLA General Hospital , No. 69, Yongding Road, Haidian District, Beijing 100039 , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjun","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Stomatology , The Third Medical Centre of PLA General Hospital , No. 69, Yongding Road, Haidian District, Beijing 100039 , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Stomatology , The Third Medical Centre of PLA General Hospital , No. 69, Yongding Road, Haidian District, Beijing 100039 , Beijing , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2026,10,16]]},"reference":[{"key":"2026101616565102432_j_biol-2025-1360_ref_001","doi-asserted-by":"crossref","unstructured":"ALHarthi, SS, BinShabaib, MS, Alwahibi, A, Gamal, S, Elashiry, EJr, Almershed, SE, et al.. 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