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The aim of this study is to investigate the polymorphisms of the SOD1 and SOD2 in Turkish vitiligo patients. One hundred one vitiligo patients and 99 healthy controls without family history of vitiligo were included into the study. The SOD1 35 A\/C and SOD2 A16V (C\/T) polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphim (PCR-RFLP). Vitiligo patients and control group of SOD1 35 A\/C and SOD2 A16V (C\/T) polymorphism allele frequencies were compared by using \u03c7<jats:sup>2<\/jats:sup> tests. The distribution of the SOD1 35 AA and AC genotypes were similar in vitiligo patients and control group. When the patient and the control groups were compared for the SOD2 Ala9Val (C\/T) polymorphism, a significant difference was determined for the distribution of the genotypes [<jats:italic>p<\/jats:italic> = 0.047, odds ratio (OR) = 2.075, 95% confidence interval (95% CI) = 1.008-4.272]. The relative risk for development of vitiligo was found as a 2-fold increase in the TT genotype. The increase of TT homozygosity in the vitiligo cases creates the problem on the transfer of the enzyme to the mitochondria and thus, the SODs antioxidant effect may decrease in vitiligo but the polymorphism was not determined in all patients, so this study needs to be substantiated by other studies containing a higher number of patients.<\/jats:p>","DOI":"10.1515\/bjmg-2017-0033","type":"journal-article","created":{"date-parts":[[2018,5,27]],"date-time":"2018-05-27T00:30:45Z","timestamp":1527381045000},"page":"67-73","source":"Crossref","is-referenced-by-count":8,"title":["<i>Superoxide dismutase 1<\/i> and <i>2<\/i> gene polymorphism in Turkish vitiligo patients"],"prefix":"10.1515","volume":"20","author":[{"given":"A","family":"Tuna","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venerology , Faculty of Medicine , Ege University , Izmir , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Ozturk","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venerology , Faculty of Medicine , Ege University , Izmir , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TB","family":"Gerceker","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venerology , Faculty of Medicine , Ege University , Izmir , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"M.D., Asso","given":"E","family":"Karaca","sequence":"additional","affiliation":[{"name":"Department of Genetics , Faculty of Medicine , Ege University , Izmir , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Onay","sequence":"additional","affiliation":[{"name":"Department of Genetics , Faculty of Medicine , Ege University , Izmir , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"SM","family":"Guvenc","sequence":"additional","affiliation":[{"name":"Department of Genetics , Faculty of Medicine , Ege University , Izmir , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O","family":"Cogulu","sequence":"additional","affiliation":[{"name":"Department of Genetics , Faculty of Medicine , Ege University , Izmir , Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2017,12,29]]},"reference":[{"key":"2021040720370806772_j_bjmg-2017-0033_ref_001_w2aab3b7c13b1b6b1ab1b4b1Aa","doi-asserted-by":"crossref","unstructured":"Alikhan A, Felsten LM, Daly M, Petronic-Rosic V. 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