{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:25:32Z","timestamp":1791239132313,"version":"4.1.0"},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMolecular Concepts"],"published-print":{"date-parts":[[2013,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Among the three peroxisome proliferator-activated receptor (PPAR) transcription factors, PPAR\u03b2\/\u03b4 is the isotype with the broadest expression pattern. In fact, the expression of PPAR\u03b2\/\u03b4 is ubiquitous, albeit at levels that are tightly regulated. Herein, we reviewed its multiple functions in skin health and disease. PPAR\u03b2\/\u03b4 has pro-differentiating effects in keratinocytes, regulates sebocyte differentiation, and promotes hair follicle growth in healthy skin. Furthermore, we reviewed novel insights into the roles of PPAR\u03b2\/\u03b4 in skin wound healing, especially in inhibiting apoptosis and in modulating keratinocyte proliferation and migration. Therefore, PPAR\u03b2\/\u03b4 represents a research target for the understanding and treatment of inflammatory skin diseases, such as psoriasis and acne vulgaris. In addition, PPAR\u03b2\/\u03b4 is a tumor growth modifier. Epidemiological studies have established that tumor progression may be exacerbated by chronic low-grade inflammation, a condition promoting the production of the lipids that act as modulators of PPAR\u03b2\/\u03b4 activity. The action of PPAR\u03b2\/\u03b4 in skin cancer is ambivalent, which might be explained by this receptor\u2019s putative highly context-specific behavior, which depends on a combination of factors ranging from receptor expression levels to co-regulator distribution, diversity and activity of the ligands produced, and other tissue-specific conditions. Given its diverse and crucial roles in many tissues and organs, PPAR\u03b2\/\u03b4 will remain a major focus of future research.<\/jats:p>","DOI":"10.1515\/bmc-2012-0035","type":"journal-article","created":{"date-parts":[[2012,11,8]],"date-time":"2012-11-08T07:40:54Z","timestamp":1352360454000},"page":"53-64","source":"Crossref","is-referenced-by-count":13,"title":["Contributions of peroxisome proliferator-activated receptor \u03b2\/\u03b4 to skin health and disease"],"prefix":"10.1515","volume":"4","author":[{"given":"Alexandra","family":"Montagner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Wahli","sequence":"additional","affiliation":[{"name":"Center for Integrative Genomics, National Research Center Frontiers in Genetics, University of Lausanne, CH-1015 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2012,11,8]]},"container-title":["bmc"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.degruyter.com\/view\/journals\/bmc\/4\/1\/article-p53.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/bmc-2012-0035\/xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/bmc-2012-0035\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T18:44:25Z","timestamp":1764960265000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyterbrill.com\/document\/doi\/10.1515\/bmc-2012-0035\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,8]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2012,11,16]]},"published-print":{"date-parts":[[2013,2,1]]}},"alternative-id":["10.1515\/bmc-2012-0035"],"URL":"https:\/\/doi.org\/10.1515\/bmc-2012-0035","relation":{},"ISSN":["1868-503X","1868-5021"],"issn-type":[{"value":"1868-503X","type":"electronic"},{"value":"1868-5021","type":"print"}],"subject":[],"published":{"date-parts":[[2012,11,8]]}}}