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The study subjects were comprised of 70 patients suffering from both T2DM and HT and 83 healthy controls. Genotyping was performed using ARMS-PCR for\n                    <jats:italic>XPD<\/jats:italic>\n                    Asp312Asn (G&gt;A) and PCR-CTPP for\n                    <jats:italic>RAD18<\/jats:italic>\n                    Arg302Gln (G&gt;A),\n                    <jats:italic>APE1<\/jats:italic>\n                    Asp148Glu (T&gt;G) and\n                    <jats:italic>OGG1<\/jats:italic>\n                    Ser326Cys (C&gt;G). The\n                    <jats:italic>RAD18<\/jats:italic>\n                    Gln\/Gln genotype was found to significantly increase the risk for T2DM and HT by 30 fold. Significant high risk was observed for individuals with\n                    <jats:italic>XPD<\/jats:italic>\n                    Asn\/Asn-\n                    <jats:italic>RAD18<\/jats:italic>\n                    Arg\/Gln genotypes. Smoking was found to be the single most important independent risk factor for T2DM and HT. This study concludes that\n                    <jats:italic>RAD18<\/jats:italic>\n                    Arg302Gln and\n                    <jats:italic>XPD<\/jats:italic>\n                    Asp312Asn polymorphisms might increase the risk for T2DM and HT in association with smoking, tobacco chewing, and\/or alcohol consumption, while\n                    <jats:italic>APE1<\/jats:italic>\n                    Asp148Glu (T&gt;G) and\n                    <jats:italic>OGG1<\/jats:italic>\n                    Ser326Cys (C&gt;G) polymorphisms do not contribute to such risk.\n                  <\/jats:p>","DOI":"10.1515\/bmc-2018-0008","type":"journal-article","created":{"date-parts":[[2018,6,10]],"date-time":"2018-06-10T18:15:42Z","timestamp":1528654542000},"page":"80-93","source":"Crossref","is-referenced-by-count":11,"title":["Polymorphisms in DNA repair genes increase the risk for type 2 diabetes mellitus and hypertension"],"prefix":"10.1515","volume":"9","author":[{"given":"Sambuddha","family":"Das","sequence":"first","affiliation":[{"name":"Department of Biotechnology , Assam University , Silchar-788011 , Assam , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukanya","family":"Purkayastha","sequence":"additional","affiliation":[{"name":"Department of Biotechnology , Assam University , Silchar-788011 , Assam , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirakjyoti","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Biotechnology , Assam University , Silchar-788011 , Assam , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anima","family":"Sinha","sequence":"additional","affiliation":[{"name":"Department of Biotechnology , Assam University , Silchar-788011 , Assam , India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yashmin","family":"Choudhury","sequence":"additional","affiliation":[{"name":"Department of Biotechnology , Assam University , Silchar-788011 , Assam , India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2018,6,9]]},"reference":[{"key":"2026053112121425468_j_bmc-2018-0008_ref_001_w2aab3b7c56b1b6b1ab2b2b1Aa","doi-asserted-by":"crossref","unstructured":"Cheung BM, Li C. 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