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A total of sixty-four rats were divided into eight groups of eight rats each as follows:1) non-diabetic control; 2, 3, and 4) non-diabetic rats treated with 15, 30, and 45 mg of\n                      <jats:italic>Spirogyra<\/jats:italic>\n                      algae\/kg\/d; 5) control diabetic; and 6, 7, and 8) diabetic rats treated with 15, 30, and 45 mg of\n                      <jats:italic>Spirogyra<\/jats:italic>\n                      algae extract. At the end of the trial, the serum concentrations of glucose, interleukin-6 (IL-6), tumor necrosis factor-a (TNF-a), malondialdehyde (MDA), glutathione (GSH), total antioxidant status (TAS), C-reactive protein (CRP), insulin, triglycerides, and cholesterol were examined by specified procedures.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_bmc-2018-0015_s_008_w2aab3b7c83b1b6b1aab1c15b3Aa\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Our findings indicated that the administration of STZ significantly increased the serum concentrations of glucose, triglycerides, cholesterol, CRP, IL-6, TNF-a, and MDA and decreased the serum levels of GSH and TAS (P&lt;0.05) in diabetic rats. Oral administration of\n                      <jats:italic>Spirogyra<\/jats:italic>\n                      alleviated adverse effects of diabetes on oxidative stress and inflammatory factors in diabetic rats (P&lt;0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"j_bmc-2018-0015_s_009_w2aab3b7c83b1b6b1aab1c15b4Aa\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      It can be stated that\n                      <jats:italic>Spirogyra<\/jats:italic>\n                      algae extract can be used for treatment of diabetes likely due to prevention of oxidative stress and alleviation of inflammation in the rat model.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1515\/bmc-2018-0015","type":"journal-article","created":{"date-parts":[[2019,1,19]],"date-time":"2019-01-19T15:56:24Z","timestamp":1547913384000},"page":"184-189","source":"Crossref","is-referenced-by-count":12,"title":["Beneficial effects of\n                    <i>Spirogyra Neglecta Extract<\/i>\n                    on antioxidant and anti-inflammatory factors in streptozotocin-induced diabetic rats"],"prefix":"10.1515","volume":"9","author":[{"given":"Behzad","family":"Mesbahzadeh","sequence":"first","affiliation":[{"name":"Cardiovascular Diseases Research Center , Birjand University of Medical Sciences , Birjand , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Ali","family":"Rajaei","sequence":"additional","affiliation":[{"name":"Oral and Maxillofacial Surgeon, Faculty of Dentistry , Semnan University of Medical Sciences , Semnan , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parnia","family":"Tarahomi","sequence":"additional","affiliation":[{"name":"Student Research Committee, Faculty of Medicine , Semnan University of Medical Sciences , Semnan , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Ali","family":"Seyedinia","sequence":"additional","affiliation":[{"name":"Student Research Committee, Faculty of Medicine , Semnan University of Medical Sciences , Semnan , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehrnoush","family":"Rahmani","sequence":"additional","affiliation":[{"name":"Student Research Committee, Faculty of Medicine , Semnan University of Medical Sciences , Semnan , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Rezamohamadi","sequence":"additional","affiliation":[{"name":"Student Research Committee, Faculty of Medicine , Semnan University of Medical Sciences , Semnan , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Azam","family":"Kakar","sequence":"additional","affiliation":[{"name":"Director Planning and Development, L&DD Department, Spinny Road Quetta , Balochistan , Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nasroallah","family":"Moradi-Kor","sequence":"additional","affiliation":[{"name":"Research Centre of Physiology, Faculty of Medicine , Semnan University of Medical Sciences , Semnan , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","published-online":{"date-parts":[[2018,12,31]]},"reference":[{"key":"2025120518153970862_j_bmc-2018-0015_ref_001_w2aab3b7c83b1b6b1ab2b1b1Aa","doi-asserted-by":"crossref","unstructured":"American Diabetes Association, \u201cDiagnosis and classification of diabetes mellitus,\u201d Diabetes Care, vol. 27, suppl 1, pp. s5\u2013s10, 2012.","DOI":"10.2337\/diacare.27.2007.S5"},{"key":"2025120518153970862_j_bmc-2018-0015_ref_002_w2aab3b7c83b1b6b1ab2b1b2Aa","doi-asserted-by":"crossref","unstructured":"Virally M, Blickl\u00e9 JF, Girard J, Halimi S, Simon D, Guillausseau PJ. 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