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Classically, oxytocin is known for inducing uterine contractions at parturition and milk ejection during suckling. Oxytocin also acts in a species and gender specific manner as an important neuromodulator. It can affect behaviours associated with stress and anxiety, as well social behaviours including sexual and relationship behaviours, and maternal care. Additionally, oxytocin has been shown to have a variety of physiological roles in peripheral tissues, many of which appear to be modulated largely by locally produced oxytocin, dispelling the notion that oxytocin is a purely neurohypophyseal hormone. Oxytocin levels are altered in several diseases and the use of oxytocin or its antagonists have been identified as a possible clinical intervention in the treatment of mood disorders and pain conditions, some cancers, benign prostatic disease and osteoporosis. Indeed, oxytocin has already been successful in clinical trials to treat autism and schizophrenia. This review will report briefly on the known functions of oxytocin, it will discuss in depth the data from recent clinical trials and highlight future targets for oxytocinergic modulation.<\/jats:p>","DOI":"10.1515\/bmc.2010.036","type":"journal-article","created":{"date-parts":[[2011,2,23]],"date-time":"2011-02-23T16:52:33Z","timestamp":1298479953000},"page":"367-380","source":"Crossref","is-referenced-by-count":4,"title":["Oxytocin: recent developments"],"prefix":"10.1515","volume":"1","author":[{"given":"Nicole C.","family":"Tom","sequence":"first","affiliation":[{"name":"Discipline of Physiology, School of Medical Sciences and Bosch Institute, University of Sydney, Sydney 2006, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen J.","family":"Assinder","sequence":"additional","affiliation":[{"name":"Discipline of Physiology, School of Medical Sciences and Bosch Institute, University of Sydney, Sydney 2006, NSW, 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