{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T03:02:24Z","timestamp":1776740544957,"version":"3.51.2"},"reference-count":50,"publisher":"Walter de Gruyter GmbH","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,8,28]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Nasoalveolar molding (NAM) is an accepted treatment strategy in presurgical cleft therapy. The major drawbacks of the treatment listed in the literature relate to the time of the treatment and the coordination of the required interdisciplinary team of therapists, parents, and patients. To overcome these limitations, we present the automated RapidNAM concept that facilitates the design and manufacturing process of NAM devices, and that allows the virtual modification and subsequent manufacture of the devices in advance, with a growth prediction factor adapted to the patient\u2019s natural growth. The RapidNAM concept involves (i) the prediction of three trajectories that envelope the fragmented alveolar segments with the goal to mimic a harmonic arch, (ii) the extrusion from the larger toward the smaller alveolar segment along the envelope curves toward the harmonic upper alveolar arch, and (iii) the generation of the NAM device with a ventilation hole, fixation pin, and fixation points for the nasal stents. A feasibility study for a vector-based approach was successfully conducted for unilateral and bilateral cleft lip and palate (CLP) patients. A comparison of the modified target models with the reference target models showed similar results. For further improvement, the number of landmarks used to modify the models was increased by a curve-based approach.<\/jats:p>","DOI":"10.1515\/bmt-2016-0035","type":"journal-article","created":{"date-parts":[[2017,2,9]],"date-time":"2017-02-09T10:02:50Z","timestamp":1486634570000},"page":"407-414","source":"Crossref","is-referenced-by-count":24,"title":["RapidNAM: generative manufacturing approach of nasoalveolar molding devices for presurgical cleft lip and palate treatment"],"prefix":"10.1515","volume":"62","author":[{"given":"Franz Xaver","family":"Bauer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Sch\u00f6nberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2968-8713","authenticated-orcid":false,"given":"Johannes","family":"Gattinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Eblenkamp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erich","family":"Wintermantel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Rau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9355-419X","authenticated-orcid":false,"given":"Florian Dieter","family":"G\u00fcll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus-Dietrich","family":"Wolff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denys J.","family":"Loeffelbein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"ref481","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1097\/SCS.0b013e3181f6f9ae","article-title":"A novel technique for presurgical nasoalveolar molding using computer-aided reverse engineering and rapid prototyping","volume":"22","year":"2011","journal-title":"J Craniofac Surg"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"903e","DOI":"10.1097\/PRS.0000000000002057","article-title":"Presurgical nasoalveolar molding for cleft lip and palate: the application of digitally designed molds","volume":"137","year":"2016","journal-title":"Plast Reconstr Surg"},{"key":"ref251","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1097\/PRS.0b013e31825dc10a","article-title":"Nasoalveolar molding in cleft care: is it efficacious?","volume":"130","year":"2012","journal-title":"Plast Reconstr Surg"},{"key":"ref121","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1097\/00006534-198401000-00009","article-title":"Nonsurgical correction of congenital auricular deformities in the early neonate: a preliminary report","volume":"73","year":"1984","journal-title":"Plast Reconstr Surg"},{"key":"ref221","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.oooo.2013.06.032","article-title":"CAD presurgical nasoalveolar molding effects on the maxillary morphology in infants with UCLP.","volume":"116","year":"2013","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"ref271","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1016\/j.jcms.2015.10.003","article-title":"A modified nasoalveolar molding technique for correction of unilateral cleft nose deformity","volume":"43","year":"2015","journal-title":"J Craniomaxillofac Surg"},{"key":"ref131","first-page":"32","article-title":"Nasoalveolar molding in cleft lip and palate, a review of literature","volume":"1","year":"2014","journal-title":"J Craniomaxillofac Res"},{"key":"ref281","doi-asserted-by":"crossref","first-page":"S74","DOI":"10.1016\/j.tripleo.2011.08.031","article-title":"Correction of maxillary deformity in infants with bilateral cleft lip and palate using computer-assisted design","volume":"114","year":"2012","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"ref301","first-page":"1422","article-title":"Preoperative columella lengthening in bilateral cleft lip and palate","volume":"92","year":"1993","journal-title":"Plast Reconstr Surg"},{"key":"ref411","doi-asserted-by":"crossref","first-page":"e0118103","DOI":"10.1371\/journal.pone.0118103","article-title":"Nasoalveolar molding in cleft care\u2014experience in 40 patients from a single centre in Germany","volume":"10","year":"2015","journal-title":"PLoS One"},{"key":"ref451","doi-asserted-by":"crossref","first-page":"112e","DOI":"10.1097\/PRS.0b013e3181cb66e0","article-title":"Optimal timing for nasal cartilage molding in presurgical nasoalveolar molding","volume":"125","year":"2010","journal-title":"Plast Reconstr Surg"},{"key":"ref351","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.bjoms.2015.03.002","article-title":"Analysis of computer-aided techniques for virtual planning in nasoalveolar moulding","volume":"53","year":"2015","journal-title":"Br J Oral Maxillofac Surg"},{"key":"ref371","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1097\/00006534-198401000-00009","article-title":"Nonsurgical correction of congenital auricular deformities in the early neonate: a preliminary report","volume":"73","year":"1984","journal-title":"Plast Reconstr Surg"},{"key":"ref211","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.cps.2013.12.003","article-title":"Classification, epidemiology, and genetics of orofacial clefts","volume":"41","year":"2014","journal-title":"Clin Plast Surg"},{"key":"ref01","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1097\/PRS.0b013e31825dc10a","article-title":"Nasoalveolar molding in cleft care: is it efficacious?","volume":"130","year":"2012","journal-title":"Plast Reconstr Surg"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"S74","DOI":"10.1016\/j.tripleo.2011.08.031","article-title":"Correction of maxillary deformity in infants with bilateral cleft lip and palate using computer-assisted design","volume":"114","year":"2012","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"ref321","first-page":"1346","article-title":"Nasoalveolar Molding (NAM) bei Lippen-Kiefer-Gaumenspalten \u2013 Praktische Herstellung der NAM-Platte","volume":"37","year":"2011","journal-title":"Quintessenz Zahntechnik"},{"key":"ref231","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1097\/SCS.0b013e3181f6f9ae","article-title":"A novel technique for presurgical nasoalveolar molding using computer-aided reverse engineering and rapid prototyping","volume":"22","year":"2011","journal-title":"J Craniofac Surg"},{"key":"ref311","year":"2014","journal-title":"An ultrasonic micro-scanner for thickness assessment of the vestibular jawbone: In-vitro accuracy evaluation."},{"key":"ref61","year":"2014","journal-title":"An ultrasonic micro-scanner for thickness assessment of the vestibular jawbone: In-vitro accuracy evaluation."},{"key":"ref491","doi-asserted-by":"crossref","first-page":"62e","DOI":"10.1097\/PRS.0b013e318267d4a5","article-title":"Limited evidence for the effect of presurgical nasoalveolar molding in unilateral cleft on nasal symmetry: a call for unified research","volume":"131","year":"2013","journal-title":"Plast Reconstr Surg"},{"key":"ref261","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1097\/PRS.0b013e318199f46e","article-title":"Nasoalveolar molding improves long-term nasal symmetry in complete unilateral cleft lip-cleft palate patients","volume":"123","year":"2009","journal-title":"Plast Reconstr Surg"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.bjoms.2015.03.002","article-title":"Analysis of computer-aided techniques for virtual planning in nasoalveolar moulding","volume":"53","year":"2015","journal-title":"Br J Oral Maxillofac Surg"},{"key":"ref171","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.jcms.2016.01.008","article-title":"Pitfalls and solutions in virtual design of nasoalveolar molding plates by using CAD\/CAM technology--a preliminary clinical study","volume":"44","year":"2016","journal-title":"J Craniomaxillofac Surg"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1597\/1545-1569(2001)038<0193:PNOMIP>2.0.CO;2","article-title":"Presurgical nasoalveolar orthopedic molding in primary correction of the nose, lip, and alveolus of infants born with unilateral and bilateral clefts","volume":"38","year":"2001","journal-title":"Cleft Palate Craniofac J"},{"key":"ref361","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1016\/j.sigpro.2007.04.004","article-title":"Overview of total least-squares methods","volume":"87","year":"2007","journal-title":"Signal Process"},{"key":"ref391","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1097\/SCS.0000000000001729","article-title":"Comparative study of early secondary nasal revisions and costs in patients with clefts treated with and without nasoalveolar molding","volume":"26","year":"2015","journal-title":"J Craniofac Surg"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1016\/j.jcms.2015.10.003","article-title":"A modified nasoalveolar molding technique for correction of unilateral cleft nose deformity","volume":"43","year":"2015","journal-title":"J Craniomaxillofac Surg"},{"key":"ref141","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1097\/SCS.0000000000001729","article-title":"Comparative study of early secondary nasal revisions and costs in patients with clefts treated with and without nasoalveolar molding","volume":"26","year":"2015","journal-title":"J Craniofac Surg"},{"key":"ref51","first-page":"1422","article-title":"Preoperative columella lengthening in bilateral cleft lip and palate","volume":"92","year":"1993","journal-title":"Plast Reconstr Surg"},{"key":"ref331","doi-asserted-by":"crossref","first-page":"903e","DOI":"10.1097\/PRS.0000000000002057","article-title":"Presurgical nasoalveolar molding for cleft lip and palate: the application of digitally designed molds","volume":"137","year":"2016","journal-title":"Plast Reconstr Surg"},{"key":"ref111","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1016\/j.sigpro.2007.04.004","article-title":"Overview of total least-squares methods","volume":"87","year":"2007","journal-title":"Signal Process"},{"key":"ref161","doi-asserted-by":"crossref","first-page":"e0118103","DOI":"10.1371\/journal.pone.0118103","article-title":"Nasoalveolar molding in cleft care\u2014experience in 40 patients from a single centre in Germany","volume":"10","year":"2015","journal-title":"PLoS One"},{"key":"ref201","doi-asserted-by":"crossref","first-page":"112e","DOI":"10.1097\/PRS.0b013e3181cb66e0","article-title":"Optimal timing for nasal cartilage molding in presurgical nasoalveolar molding","volume":"125","year":"2010","journal-title":"Plast Reconstr Surg"},{"key":"ref241","doi-asserted-by":"crossref","first-page":"62e","DOI":"10.1097\/PRS.0b013e318267d4a5","article-title":"Limited evidence for the effect of presurgical nasoalveolar molding in unilateral cleft on nasal symmetry: a call for unified research","volume":"131","year":"2013","journal-title":"Plast Reconstr Surg"},{"key":"ref401","doi-asserted-by":"crossref","first-page":"693","DOI":"10.2298\/VSP1407693R","article-title":"Presurgical orthodontic treatment of patients with complete bilateral cleft lip and palate","volume":"71","year":"2014","journal-title":"Vojnosanit Pregl"},{"key":"ref191","doi-asserted-by":"crossref","first-page":"1007e","DOI":"10.1097\/PRS.0000000000001286","article-title":"Presurgical nasoalveolar molding for cleft lip and palate: the application of digitally designed molds","volume":"135","year":"2015","journal-title":"Plast Reconstr Surg"},{"key":"ref461","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.cps.2013.12.003","article-title":"Classification, epidemiology, and genetics of orofacial clefts","volume":"41","year":"2014","journal-title":"Clin Plast Surg"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1097\/PRS.0b013e318199f46e","article-title":"Nasoalveolar molding improves long-term nasal symmetry in complete unilateral cleft lip-cleft palate patients","volume":"123","year":"2009","journal-title":"Plast Reconstr Surg"},{"key":"ref471","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.oooo.2013.06.032","article-title":"CAD presurgical nasoalveolar molding effects on the maxillary morphology in infants with UCLP.","volume":"116","year":"2013","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"ref291","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1597\/1545-1569(2001)038<0193:PNOMIP>2.0.CO;2","article-title":"Presurgical nasoalveolar orthopedic molding in primary correction of the nose, lip, and alveolus of infants born with unilateral and bilateral clefts","volume":"38","year":"2001","journal-title":"Cleft Palate Craniofac J"},{"key":"ref341","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.bjoms.2013.01.012","article-title":"Impression technique for monitoring and virtual treatment planning in nasoalveolar moulding","volume":"51","year":"2013","journal-title":"Br J Oral Maxillofac Surg"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.bjoms.2013.01.012","article-title":"Impression technique for monitoring and virtual treatment planning in nasoalveolar moulding","volume":"51","year":"2013","journal-title":"Br J Oral Maxillofac Surg"},{"key":"ref181","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/SCS.0000000000001233","article-title":"Assessment of presurgical clefts and predicted surgical outcome in patients treated with and without nasoalveolar molding","volume":"26","year":"2015","journal-title":"J Craniofac Surg"},{"key":"ref421","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.jcms.2016.01.008","article-title":"Pitfalls and solutions in virtual design of nasoalveolar molding plates by using CAD\/CAM technology--a preliminary clinical study","volume":"44","year":"2016","journal-title":"J Craniomaxillofac Surg"},{"key":"ref71","first-page":"1346","article-title":"Nasoalveolar Molding (NAM) bei Lippen-Kiefer-Gaumenspalten \u2013 Praktische Herstellung der NAM-Platte","volume":"37","year":"2011","journal-title":"Quintessenz Zahntechnik"},{"key":"ref151","doi-asserted-by":"crossref","first-page":"693","DOI":"10.2298\/VSP1407693R","article-title":"Presurgical orthodontic treatment of patients with complete bilateral cleft lip and palate","volume":"71","year":"2014","journal-title":"Vojnosanit Pregl"},{"key":"ref381","first-page":"32","article-title":"Nasoalveolar molding in cleft lip and palate, a review of literature","volume":"1","year":"2014","journal-title":"J Craniomaxillofac Res"},{"key":"ref441","doi-asserted-by":"crossref","first-page":"1007e","DOI":"10.1097\/PRS.0000000000001286","article-title":"Presurgical nasoalveolar molding for cleft lip and palate: the application of digitally designed molds","volume":"135","year":"2015","journal-title":"Plast Reconstr Surg"},{"key":"ref431","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/SCS.0000000000001233","article-title":"Assessment of presurgical clefts and predicted surgical outcome in patients treated with and without nasoalveolar molding","volume":"26","year":"2015","journal-title":"J Craniofac Surg"}],"container-title":["Biomedical Engineering \/ Biomedizinische Technik"],"original-title":[],"link":[{"URL":"http:\/\/www.degruyter.com\/view\/j\/bmte.2017.62.issue-4\/bmt-2016-0035\/bmt-2016-0035.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.degruyter.com\/view\/j\/bmte.2017.62.issue-4\/bmt-2016-0035\/bmt-2016-0035.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,27]],"date-time":"2021-02-27T20:07:19Z","timestamp":1614456439000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/bmt-2016-0035\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,28]]},"references-count":50,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.1515\/bmt-2016-0035","relation":{},"ISSN":["1862-278X","0013-5585"],"issn-type":[{"value":"1862-278X","type":"electronic"},{"value":"0013-5585","type":"print"}],"subject":[],"published":{"date-parts":[[2017,8,28]]}}}