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The SHG pattern of CoA depended on laser polarization, indicating that a radial structure is responsible for their nonlinear activity. Vibrational spectroscopy was used to study the biochemistry underlying the SHG activity. Infrared (IR) and Raman spectroscopy showed that CoA contain polyglucosans that are biochemically similar to glycogen, but with an unusual structure that is similar to amylopectin, which justifies the nonlinear activity of CoA. Our findings explain the SHG activity of CoA and demonstrate that CoA in the pathological brain are amenable to label-free multiphoton imaging. Further research will clarify whether intraoperative assessment of CoA can be diagnostically exploited.<\/jats:p>","DOI":"10.1515\/bmt-2017-0073","type":"journal-article","created":{"date-parts":[[2018,2,28]],"date-time":"2018-02-28T22:18:59Z","timestamp":1519856339000},"page":"579-585","source":"Crossref","is-referenced-by-count":14,"title":["Optical molecular imaging of corpora amylacea in human brain tissue"],"prefix":"10.1515","volume":"63","author":[{"given":"Roberta","family":"Galli","sequence":"first","affiliation":[{"name":"Clinical Sensoring and Monitoring, Clinic of Anesthesiology and Intensive Care Therapy, Medical Faculty , TU Dresden , 01307 Dresden , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Meinhardt","sequence":"additional","affiliation":[{"name":"Pathology, University Hospital Carl Gustav Carus , TU Dresden , 01307 Dresden , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmund","family":"Koch","sequence":"additional","affiliation":[{"name":"Clinical Sensoring and Monitoring, Clinic of Anesthesiology and Intensive Care Therapy, Medical Faculty , TU Dresden , 01307 Dresden , Germany"},{"name":"Center for Regenerative Therapies , TU Dresden , 01307 Dresden , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Schackert","sequence":"additional","affiliation":[{"name":"Neurosurgery , University Hospital Carl Gustav Carus, TU Dresden , 01307 Dresden , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Steiner","sequence":"additional","affiliation":[{"name":"Clinical Sensoring and Monitoring, Clinic of Anesthesiology and Intensive Care Therapy, Medical Faculty , TU Dresden , 01307 Dresden , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Kirsch","sequence":"additional","affiliation":[{"name":"Center for Regenerative Therapies , TU Dresden , 01307 Dresden , Germany"},{"name":"Neurosurgery , University Hospital Carl Gustav Carus, TU Dresden , 01307 Dresden , Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ortrud","family":"Uckermann","sequence":"additional","affiliation":[{"name":"Neurosurgery , University Hospital Carl Gustav Carus, TU Dresden , Fetscherstr. 74 , 01307 Dresden , Germany , Phone: +49 351 4583114, Fax: +49 351 4584304"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2018,2,28]]},"reference":[{"key":"2021021300270405461_j_bmt-2017-0073_ref_001_w2aab3b7b6b1b6b1ab2b1b1Aa","unstructured":"Ahn T-B, Langston JW, Aachi VR, Dickson DW. 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