{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T04:49:21Z","timestamp":1784004561961,"version":"3.55.0"},"reference-count":41,"publisher":"Walter de Gruyter GmbH","issue":"5","funder":[{"DOI":"10.13039\/501100001858","name":"VINNOVA","doi-asserted-by":"publisher","award":["2017-02130"],"award-info":[{"award-number":["2017-02130"]}],"id":[{"id":"10.13039\/501100001858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec id=\"j_bmt-2022-0386_abs_001\">\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Patients with urethral stricture due to any type of trauma, hypospadias or gender dysphoria suffer immensely from impaired capacity to urinate and are in need of a new functional urethra. Tissue engineering with decellularization of a donated organ recellularized with cells from the recipient patient has emerged as a promising alternative of advanced therapy medicinal products. The aim of this pilot study was to develop an ovine model of urethral transplantation and to produce an individualized urethra graft to show proof of function <jats:italic>in\u00a0vivo<\/jats:italic>.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_bmt-2022-0386_abs_002\">\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Donated urethras from ram abattoir waste were decellularized and further recellularized with autologous buccal mucosa epithelial cells excised from the recipient ram and expanded <jats:italic>in\u00a0vitro<\/jats:italic>. The individualized urethral grafts were implanted by reconstructive surgery in rams replacing 2.5\u00a0\u00b1\u00a00.5\u00a0cm of the native penile urethra.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_bmt-2022-0386_abs_003\">\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>After surgery optimization, three ram had the tissue engineered urethra implanted for one month and two out of three showed a partially regenerated epithelium.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec id=\"j_bmt-2022-0386_abs_004\">\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Further adjustments of the model are needed to achieve a satisfactory proof-of-concept; however, we interpret these findings as a proof of principle and a possible path to develop a functional tissue engineered urethral graft with de- and recellularization and regeneration <jats:italic>in\u00a0vivo<\/jats:italic> after transplantation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1515\/bmt-2022-0386","type":"journal-article","created":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T07:07:53Z","timestamp":1680246473000},"page":"493-501","source":"Crossref","is-referenced-by-count":4,"title":["De- and recellularized urethral reconstruction with autologous buccal mucosal cells implanted in an ovine animal model"],"prefix":"10.1515","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4270-8475","authenticated-orcid":false,"given":"Joakim","family":"H\u00e5kansson","sequence":"first","affiliation":[{"name":"Division Materials and production , RISE Research Institutes of Sweden, Unit of Biological Function , Bor\u00e5s , Sweden"},{"name":"Department of Laboratory Medicine , Institute of Biomedicine, University of Gothenburg , Gothenburg , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lachmi","family":"Jenndahl","sequence":"additional","affiliation":[{"name":"VERIGRAFT AB , Gothenburg , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stina","family":"Simonsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry and Transfusion Medicine , Institute of Biomedicine at Sahlgrenska Academy, University of Gothenburg , Gothenburg , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin E.","family":"Johansson","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology , Sahlgrenska University Hospital , Gothenburg , Sweden"},{"name":"Department of Laboratory Medicine , Institute of Biomedicine, Sahlgrenska Center for Cancer Research, Sahlgrenska Academy, University of Gothenburg , Gothenburg , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Larsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry and Transfusion Medicine , Institute of Biomedicine at Sahlgrenska Academy, University of Gothenburg , Gothenburg , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raimund","family":"Strehl","sequence":"additional","affiliation":[{"name":"VERIGRAFT AB , Gothenburg , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Olsen Ekerhult","sequence":"additional","affiliation":[{"name":"Department of Urology , Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg , Gothenburg , Sweden"},{"name":"Department of Urology , V\u00e4stra G\u00f6taland Region, Sahlgrenska University Hospital , Gothenburg , Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","published-online":{"date-parts":[[2023,4,3]]},"reference":[{"key":"2023100508034015026_j_bmt-2022-0386_ref_001","doi-asserted-by":"crossref","unstructured":"Anger, JT, Buckley, JC, Santucci, RA, Elliott, SP, Saigal, CS, Urologic Diseases in America P. 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