{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T19:57:46Z","timestamp":1648670266542},"reference-count":20,"publisher":"Walter de Gruyter GmbH","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Zur Beurteilung des radiologischen, biomechanischen und histologischen Einwachsverhaltens neuer Materialien, Implantate und Cages f\u00fcr die zervikale interkorporelle Fusion, bieten sich Tiermodelle und hier insbesondere das Schafs-Halswirbels\u00e4ulenmodell an.<\/jats:p><jats:p>In biomechanischen In-vitro-Versuchen an humanen Kadaver-Halswirbels\u00e4ulen wurden erste Erfahrungen hinsichtlich Prim\u00e4rstabilit\u00e4t eines Cage aus einer neuartigen, por\u00f6sen TiO<\/jats:p><jats:p>Zur entsprechenden In-vivo-Beurteilung fusionierten wir 10 Schafs-Halswirbels\u00e4ulen in den H\u00f6hen C2\/3 und C4\/5 jeweils mit PMMA und einem Ecopore-Keramik-Cage und f\u00fchrten nativradiologische, sowie computertomographische Verlaufsuntersuchungen direkt post-operativ und alle 4 Wochen in den folgenden 2 bzw. 4 Monaten durch. Neben der Etablierung des Tiermodells, wurden die radiologischen Ver\u00e4nderungen im Verlauf und die Fusion der operierten Segmente analysiert. Dar\u00fcberhinaus wurden Messungen der entsprechenden Bandscheibenfachh\u00f6hen (DSH) und Intervertebralwinkel (IVA) durchgef\u00fchrt und verglichen.<\/jats:p><jats:p>Nach Einbringen der Implantate in die Bandscheibenf\u00e4cher nahm zun\u00e4chst in beiden Gruppen die mittlere Bandscheibenfachh\u00f6he und der Intervertebralwinkel zu (34,8%; 53,9%). In den folgenden Monaten verringerte sich die Bandscheibenfachh\u00f6he nicht signifikant, deutlicher nach Ecopore-Fusion als nach PMMA-Interposition bis auf Werte unterhalb der Ausgangswerte. Ebenso nahm der Intervertebralwinkel im postoperativen Verlauf, deutlicher in der Ecopore-Gruppe als in der PMMA-Gruppe, ab (p &lt; 0,05). Diese Ver\u00e4nderungen im Sinne einer Einsinterung der Implantate, konnte in den radiologischen Verlaufskontrollen morphologisch best\u00e4tigt werden. Die radiologisch beurteilbare Fusion, d.h. solide kn\u00f6cherne \u00dcberbauung des operierten Segments, war nach Implantation eines Ecopore-Cage ausgepr\u00e4gter (83%) als nach PMMA-Interposition (50%) (nicht statistisch signifikant).<\/jats:p><jats:p>In diesem ersten Teil unserer In-vivo-Untersuchungen zu dem Einsatz des neuartigen Cage-Materials wurde die Anwendung im Spondylodesemodell der Schafs-Halswirbels\u00e4ule aufgezeigt. Es zeigten sich radiologische Unterschiede, in Bezug auf die ausgepr\u00e4gtere Einsinterung des Ecopore-Cage und die deutlichere, nachweisbare Fusion des mit dem neuen Material operierten Segments. In dem ersten Teil dieser Studie wurden die radiologischen Ver\u00e4nderungen der fusionierten Segmente \u00fcber mehrere Monate dargestellt und morphologisch analysiert, bevor die biomechanischen Analysen und Vergleiche in einem weiteren Teil pr\u00e4sentiert werden sollen.<\/jats:p><jats:p>\u00a0<\/jats:p><jats:p>Animals are becoming more and more common as in vitro and in vivo models for the human spine. Especially the sheep cervical spine is stated to be of good comparability and usefulness in the evaluation of in vivo radiological, biomechanical and histological behaviour of new bone replacement materials, implants and cages for cervical spine interbody fusion.<\/jats:p><jats:p>In preceding biomechanical in vitro examination human cervical spine specimens were tested after fusion with either a cubical stand-alone interbody fusion cage manufactured from a new porous TiO<\/jats:p><jats:p>Immediately after placement of both implants in the disc spaces the mean DSH and IVA increased (34.8% and 53.9%, respectively). During the following months DSH decreased to a greater extent in the Ecopore-segments than in the PMMA-segments, even to a value below the initial value (p &gt; 0,05). Similarly, the IVA decreased in both groups in the postoperative time lapse, but more distinct in the Ecopore-segments (p &lt; 0,05). These changes in terms of a subsidence of the implants, were confirmed morphologically in the radiological examination in the course. The radiologically evaluated fusion, i.e. bony bridging of the operated segments, was more pronounced after implantation of an Ecopore-cage (83%), than after PMMA interposition (50%), but did not gain statistical significance.<\/jats:p><jats:p>In this first in vivo examination of our new porous ceramic bone replacement material we showed its application in the spondylodesis model of the sheep cervical spine. Distinct radiological changes regarding evident subsidence and detectable fusion of the segments, operated on with the new biomaterial, were seen. We demonstrated the radiological changes of the fused segments during several months and analysed them morphologically, before the biomechanical evaluation will be presented in a subsequent publication.<\/jats:p>","DOI":"10.1515\/bmt.2004.066","type":"journal-article","created":{"date-parts":[[2008,3,17]],"date-time":"2008-03-17T18:12:22Z","timestamp":1205777542000},"source":"Crossref","is-referenced-by-count":3,"title":["Anwendung eines Bandscheibenersatzimplantats aus einer neuartigen por\u00f6sen TiO2\/Glas-Keramik \u2013 Teil 1: Einsatz in der Schafs-Halswirbels\u00e4ule und radiologische Verlaufsuntersuchungen \/ Application of a Stand-Alone Interbody Fusion Cage Based on a Novel Porous TiO2\/glass Composite \u2013 Part 1: Implantation in the Sheep Cervical Spine and Radiological Evaluation"],"prefix":"10.1515","volume":"49","author":[{"given":"M. C","family":"Korinth","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Hero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. H","family":"Mahnken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Rago\u00df","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Scherer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","reference":[{"key":"p_1","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3171\/spi.2003.98.2.0195","volume":"98","author":"Cahill D. W.","year":"2003","journal-title":"J. Neurosurg. (Spine)"},{"key":"p_2","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1097\/00007632-199504000-00002","volume":"20","author":"Cain C. C. M.","year":"1995","journal-title":"Spine"},{"key":"p_3","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-30714"},{"key":"p_4","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200109010-00007"},{"key":"p_5","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200105010-00008"},{"key":"p_6","doi-asserted-by":"publisher","DOI":"10.1007\/s00104-002-0489-2"},{"key":"p_7","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1515\/bmte.2003.48.12.349","volume":"48","author":"Korinth M. C.","year":"2003","journal-title":"Biomedizinische Technik"},{"key":"p_8","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-199901000-00085"},{"key":"p_9","doi-asserted-by":"publisher","DOI":"10.1007\/s005860000203"},{"key":"p_10","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4636(199723)38:3<267::AID-JBM12>3.0.CO;2-8"},{"key":"p_11","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-002-0939-0"},{"key":"p_13","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199510001-00003"},{"key":"p_14","first-page":"223","volume":"96","author":"Robinson R. A.","year":"1955","journal-title":"Bull. Johns Hopkins Hosp."},{"key":"p_15","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1097\/00007632-199409000-00023","volume":"19","author":"Schimandle J. H.","year":"1994","journal-title":"Spine"},{"key":"p_16","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1515\/bmte.2003.48.7-8.213","volume":"48","author":"Schopphoff E.","year":"2003","journal-title":"Biomedizinische Technik"},{"key":"p_17","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-200110000-00023"},{"key":"p_18","doi-asserted-by":"publisher","DOI":"10.1007\/PL00010027"},{"key":"p_19","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199510001-00005"},{"key":"p_20","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199710150-00009"},{"key":"p_21","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199804010-00002"}],"container-title":["Biomedizinische Technik\/Biomedical Engineering"],"original-title":[],"link":[{"URL":"http:\/\/www.degruyter.com\/view\/j\/bmte.2004.49.issue-12\/bmt.2004.066\/bmt.2004.066.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.degruyter.com\/view\/j\/bmte.2004.49.issue-12\/bmt.2004.066\/bmt.2004.066.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,27]],"date-time":"2021-02-27T20:13:02Z","timestamp":1614456782000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.degruyter.com\/document\/doi\/10.1515\/BMT.2004.066\/html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12,1]]},"references-count":20,"journal-issue":{"issue":"12"},"URL":"https:\/\/doi.org\/10.1515\/bmt.2004.066","relation":{},"ISSN":["0013-5585","1862-278X"],"issn-type":[{"value":"0013-5585","type":"print"},{"value":"1862-278X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,12,1]]}}}